The DOI matches its Crossref record; 48 of the 48 references it cites were found in a registry or an index.
Favipiravir at high doses has potent antiviral activity in SARS-CoV-2−infected hamsters, whereas hydroxychloroquine lacks activity
Open accessAbstract
Significance: The previous lack of consensus around the use of hydroxychloroquine for COVID-19 patients underlines the need to thoroughly assess the in vivo efficacy of drugs against SARS-CoV-2. Small animal infection models, such as the hamster model, have a pivotal place herein. We here show in vivo preclinical results with favipiravir which indicate that antiviral efficacy against SARS-CoV-2 might only be achieved with a very high dose. Hydroxychloroquine, on the other hand, completely lacks antiviral activity, thus providing no scientific basis for its further use in COVID-19 patients. With this study on two key antiviral candidates, we establish the baseline for SARS-CoV-2 antiviral treatment, which will allow us to identify superior antiviral candidates in the near future.
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Self-citationPathogenesis and transmission of SARS-CoV-2 in golden hamsters
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Cited by
Daems, M., Liesenborghs, L., Boudewijns, R., Simmonds, S. J., Kraisin, S., Van Wauwe, J., Cuijpers, I., Raman, J., Geuens, N., Buyten, T. V., et al. (2022) · Frontiers in Cardiovascular Medicine · doi:10.3389/fcvm.2022.964512 · Cited by 8
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Metadata
- Authors
- Kaptein, S. J. F., Jacobs, S., Langendries, L., Seldeslachts, L., ter Horst, S., Liesenborghs, L., Hens, B., Vergote, V., Heylen, E., Barthelemy, K., Maas, E., De Keyzer, C., Bervoets, L., Rymenants, J., Van Buyten, T., Zhang, X., Abdelnabi, R., Pang, J., Williams, R., Thibaut, H. J., Dallmeier, K., Boudewijns, R., Wouters, J., Augustijns, P., Verougstraete, N., Cawthorne, C., Breuer, J., Solas, C., Weynand, B., Annaert, P., Spriet, I., Vande Velde, G., Neyts, J., Rocha-Pereira, J., & Delang, L.
- Venue
- Proceedings of the National Academy of Sciences
- Published
- 2020-10-09
- Volume
- 117
- Issue
- 43
- Pages
- 26955-26965
- ISSN
- 0027-8424 (ISSN-L)
- 1091-6490
- OpenAlex
- W3092285496
- Cited by
- 269
- References
- 48
- FWCI
- 6.67
- Type
- journal article
- Language
- en
- Open access
- hybrid
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- Kaptein, S. J. F., Jacobs, S., Langendries, L., Seldeslachts, L., ter Horst, S., Liesenborghs, L., Hens, B., Vergote, V., Heylen, E., Barthelemy, K., Maas, E., De Keyzer, C., Bervoets, L., Rymenants, J., Van Buyten, T., Zhang, X., Abdelnabi, R., Pang, J., Williams, R., . . . Delang, L. (2020). Favipiravir at high doses has potent antiviral activity in SARS-CoV-2−infected hamsters, whereas hydroxychloroquine lacks activity. Proceedings of the National Academy of Sciences. https://doi.org/10.1073/pnas.2014441117
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Contains information from the Semantic Scholar Academic Graph Datasets, made available under the ODC Attribution License (ODC-BY 1.0).
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