The DOI matches its Crossref record; 1 of the 1 references it cites were found in a registry or an index.
Galectin-1 is a stromal cell ligand of the pre-B cell receptor (BCR) implicated in synapse formation between pre-B and stromal cells and in pre-BCR triggering
Open accessAbstract
Although preB cell-receptor (pre-BCR) formation and cell-surface expression is essential for B cell development, pre-BCR generation of signal transduction remains elusive. Here, we report that recombinant pre-BCRs and the surrogate light chain bind specifically to the bone marrow stromal cell galectin-1 (GAL1), an S-type lectin. The surrogate light chain/GAL1 association is a direct protein–protein interaction (Ka= 2 × 10 6 M−1), and the NH 2 extra loop of λ-like is the major binding element. Pre-BCR binding to stromal cells depends upon GAL1 anchoring to glycosylated counter-receptors, and these complexes completely relocalize to form a synapse at the contact zone between preB and stromal cells. This immune developmental synapse is accompanied by the initiation of intracellular tyrosine kinase activity and signal transduction from the pre-BCR.
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Cites
Galectins: A family of animal β-galactoside-binding lectins
Barondes, S. H., Castronovo, V., Cooper, D. N. W., Cummings, R. D., Drickamer, K., Felzi, T., Gitt, M. A., Hirabayashi, J., Hughes, C., Kasai, K.-I., et al. (1994) · Cell · doi:10.1016/0092-8674(94)90498-7 · Cited by 1,223
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Koopman, L. A., Kopcow, H. D., Rybalov, B., Boyson, J. E., Orange, J. S., Schatz, F., Masch, R., Lockwood, C. J., Schachter, A. D., Park, P. J., et al. (2003) · The Journal of Experimental Medicine · doi:10.1084/jem.20030305 · Cited by 909
Galectin-1: a small protein with major functions
Camby, I., Le Mercier, M., Lefranc, F., & Kiss, R. (2006) · Glycobiology · doi:10.1093/glycob/cwl025 · Cited by 893
Targeting Bruton's tyrosine kinase in B cell malignancies
Hendriks, R. W., Yuvaraj, S., & Kil, L. P. (2014) · Nature Reviews Cancer · doi:10.1038/nrc3702 · Cited by 552
Galectins: regulators of acute and chronic inflammation
Liu, F., & Rabinovich, G. A. (2010) · Annals of the New York Academy of Sciences · doi:10.1111/j.1749-6632.2009.05131.x · Cited by 405
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Monroe, J. G. (2006) · Nature Reviews Immunology · doi:10.1038/nri1808 · Cited by 313
Metadata
- Authors
- Gauthier, L., Rossi, B., Roux, F., Termine, E., & Schiff, C.
- Venue
- Proceedings of the National Academy of Sciences
- Published
- 2002-09-23
- Volume
- 99
- Issue
- 20
- Pages
- 13014-13019
- ISSN
- 0027-8424 (ISSN-L)
- 1091-6490
- OpenAlex
- W2116764567
- Cited by
- 268
- References
- 1
- FWCI
- 5.95
- Type
- journal article
- Language
- en
- Open access
- bronze
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- CoChat. (2026). Citation check: Galectin-1 is a stromal cell ligand of the pre-B cell receptor (BCR) implicated in synapse formation between pre-B and stromal cells and in pre-BCR triggering. https://app.cochat.ai/papers/10.1073/pnas.202323999
- The paper
- Gauthier, L., Rossi, B., Roux, F., Termine, E., & Schiff, C. (2002). Galectin-1 is a stromal cell ligand of the pre-B cell receptor (BCR) implicated in synapse formation between pre-B and stromal cells and in pre-BCR triggering. Proceedings of the National Academy of Sciences. https://doi.org/10.1073/pnas.202323999
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