The DOI matches its Crossref record; 161 of the 161 references it cites were found in a registry or an index.
Galectins: regulators of acute and chronic inflammation
Open accessAbstract
Galectins, β‐galactoside‐binding animal lectins, are differentially expressed by various immune cells as well as a wide range of other cell types. Extracellularly, galectins are able to exhibit bivalent or multivalent interactions with cell‐surface glycans on various immune cells and exert various effects. These include cytokine and mediator production, cell adhesion, apoptosis, and chemoattraction. In addition, they can form lattices with cell‐surface glycoprotein receptors, resulting in modulation of receptor functions, including clustering and endocytosis. Intracellularly, galectins can participate in signaling pathways and modulate biologic responses. These include apoptosis, cell differentiation, and cell migration. Thus, a large body of literature indicates that galectins play important roles in the immune and inflammatory responses through regulating the homeostasis and functions of immune cells. The use of mice deficient in individual galectins has provided additional evidence for the contributions of these proteins to these responses. Current research indicates that galectins play important roles in the development of acute inflammation as well as chronic inflammation associated with allergies, autoimmune diseases, atherosclerosis, infectious processes, and cancer. Thus, recombinant proteins or specific galectin inhibitors may be used as therapeutic agents for inflammatory diseases.
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1 retracted
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RetractedThe Tim-3 ligand galectin-9 negatively regulates T helper type 1 immunity
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Apoptosis of T cells mediated by galectin-1
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Exosome: from internal vesicle of the multivesicular body to intercellular signaling device
Denzer, K., Kleijmeer, M. J., Heijnen, H. F. G., Stoorvogel, W., & Geuze, H. J. (2000) · Journal of Cell Science · doi:10.1242/jcs.113.19.3365 · Cited by 1,067
Negative regulation of T-cell activation and autoimmunity by Mgat5 N-glycosylation
Demetriou, M., Granovsky, M., Quaggin, S., & Dennis, J. W. (2001) · Nature · doi:10.1038/35055582 · Cited by 901
Galectins: structure, function and therapeutic potential
Yang, R.-Y., Rabinovich, G. A., & Liu, F.-T. (2008) · Expert Reviews in Molecular Medicine · doi:10.1017/s1462399408000719 · Cited by 862
Self-citationExpression of galectin-3 modulates T-cell growth and apoptosis.
Yang, R. Y., Hsu, D. K., & Liu, F. T. (1996) · Proceedings of the National Academy of Sciences · doi:10.1073/pnas.93.13.6737 · Cited by 789
Self-citationIntracellular functions of galectins
Liu, F. (2002) · Biochimica et Biophysica Acta (BBA) - General Subjects · doi:10.1016/s0304-4165(02)00313-6 · Cited by 675
Self-citationToscano, M. A., Bianco, G. A., Ilarregui, J. M., Croci, D. O., Correale, J., Hernandez, J. D., Zwirner, N. W., Poirier, F., Riley, E. M., Baum, L. G., et al. (2007) · Nature Immunology · doi:10.1038/ni1482 · Cited by 653
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Cited by
CA 19-9: Biochemical and Clinical Aspects
Scarà, S., Bottoni, P., & Scatena, R. (2015) · Advances in Experimental Medicine and Biology · doi:10.1007/978-94-017-7215-0_15 · Cited by 351
Galectin-9-CD44 Interaction Enhances Stability and Function of Adaptive Regulatory T Cells
Wu, C., Thalhamer, T., Franca, R. F., Xiao, S., Wang, C., Hotta, C., Zhu, C., Hirashima, M., Anderson, A. C., & Kuchroo, V. K. (2014) · Immunity · doi:10.1016/j.immuni.2014.06.011 · Cited by 349
When Galectins Recognize Glycans: From Biochemistry to Physiology and Back Again
Di Lella, S., Sundblad, V., Cerliani, J. P., Guardia, C. M., Estrin, D. A., Vasta, G. R., & Rabinovich, G. A. (2011) · Biochemistry · doi:10.1021/bi201121m · Cited by 282
Self-citationGalectin-3 promotes Aβ oligomerization and Aβ toxicity in a mouse model of Alzheimer’s disease
Tao, C.-C., Cheng, K.-M., Ma, Y.-L., Hsu, W.-L., Chen, Y.-C., Fuh, J.-L., Lee, W.-J., Chao, C.-C., & Lee, E. H. Y. (2020) · Cell Death & Differentiation · doi:10.1038/s41418-019-0348-z · Cited by 138
Recurrent infection progressively disables host protection against intestinal inflammation
Yang, W. H., Heithoff, D. M., Aziz, P. V., Sperandio, M., Nizet, V., Mahan, M. J., & Marth, J. D. (2017) · Science · doi:10.1126/science.aao5610 · Cited by 104
Metadata
- Authors
- Liu, F., & Rabinovich, G. A.
- Venue
- Annals of the New York Academy of Sciences
- Publisher
- Wiley
- Published
- 2010-01
- Volume
- 1183
- Issue
- 1
- Pages
- 158-182
- ISSN
- 0077-8923 (ISSN-L)
- 1749-6632
- OpenAlex
- W1789328091
- Cited by
- 405
- References
- 161
- FWCI
- 10.77
- Type
- journal article
- Language
- en
- Open access
- bronze
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