The DOI matches its Crossref record; 3 of the 3 references it cites were found in a registry or an index.
The role of chromosomal instability in tumor initiation
Open accessAbstract
Chromosomal instability (CIN) is a defining characteristic of most human cancers. Mutation of CIN genes increases the probability that whole chromosomes or large fractions of chromosomes are gained or lost during cell division. The consequence of CIN is an imbalance in the number of chromosomes per cell (aneuploidy) and an enhanced rate of loss of heterozygosity. A major question of cancer genetics is to what extent CIN, or any genetic instability, is an early event and consequently a driving force for tumor progression. In this article, we develop a mathematical framework for studying the effect of CIN on the somatic evolution of cancer. Specifically, we calculate the conditions for CIN to initiate the process of colorectal tumorigenesis before the inactivation of tumor suppressor genes.
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Cites
Genetic instabilities in human cancers
Lengauer, C., Kinzler, K. W., & Vogelstein, B. (1998) · Nature · doi:10.1038/25292 · Cited by 4,168
A human DNA segment with properties of the gene that predisposes to retinoblastoma and osteosarcoma
Friend, S. H., Bernards, R., Rogelj, S., Weinberg, R. A., Rapaport, J. M., Albert, D. M., & Dryja, T. P. (1986) · Nature · doi:10.1038/323643a0 · Cited by 2,948
Connecting Chromosomes, Crisis, and Cancer
Maser, R. S., & DePinho, R. A. (2002) · Science · doi:10.1126/science.297.5581.565 · Cited by 561
Cited by
A Big Bang model of human colorectal tumor growth
Sottoriva, A., Kang, H., Ma, Z., Graham, T. A., Salomon, M. P., Zhao, J., Marjoram, P., Siegmund, K., Press, M. F., Shibata, D., et al. (2015) · Nature Genetics · doi:10.1038/ng.3214 · Cited by 1,015
Genomic and Epigenetic Instability in Colorectal Cancer Pathogenesis
Grady, W. M., & Carethers, J. M. (2008) · Gastroenterology · doi:10.1053/j.gastro.2008.07.076 · Cited by 960
Mad2 Overexpression Promotes Aneuploidy and Tumorigenesis in Mice
Sotillo, R., Hernando, E., Díaz-Rodríguez, E., Teruya-Feldstein, J., Cordón-Cardo, C., Lowe, S. W., & Benezra, R. (2007) · Cancer Cell · doi:10.1016/j.ccr.2006.10.019 · Cited by 612
The significance of unstable chromosomes in colorectal cancer
Rajagopalan, H., Nowak, M. A., Vogelstein, B., & Lengauer, C. (2003) · Nature Reviews Cancer · doi:10.1038/nrc1165 · Cited by 502
Self-citationCancer in xeroderma pigmentosum and related disorders of DNA repair
Cleaver, J. E. (2005) · Nature Reviews Cancer · doi:10.1038/nrc1652 · Cited by 427
Metadata
- Authors
- Nowak, M. A., Komarova, N. L., Sengupta, A., Jallepalli, P. V., Shih, I.-M., Vogelstein, B., & Lengauer, C.
- Venue
- Proceedings of the National Academy of Sciences
- Published
- 2002-11-21
- Volume
- 99
- Issue
- 25
- Pages
- 16226-16231
- ISSN
- 0027-8424 (ISSN-L)
- 1091-6490
- OpenAlex
- W1968407767
- Cited by
- 523
- References
- 3
- FWCI
- 12.30
- Type
- journal article
- Language
- en
- Open access
- green
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- Nowak, M. A., Komarova, N. L., Sengupta, A., Jallepalli, P. V., Shih, I.-M., Vogelstein, B., & Lengauer, C. (2002). The role of chromosomal instability in tumor initiation. Proceedings of the National Academy of Sciences. https://doi.org/10.1073/pnas.202617399
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