The DOI matches its Crossref record; 2 of the 2 references it cites were found in a registry or an index.
The population structure of Mycobacterium bovis in Great Britain: Clonal expansion
Open accessAbstract
We have analyzed 11,500 isolates of Mycobacterium bovis (the cause of tuberculosis in cattle and other mammals) isolated in Great Britain (England, Wales and Scotland)] and characterized by spoligotype. Genetic exchange between cells is rare or absent in strains of the Mycobacterium tuberculosis complex so that, by using spoligotypes, it is possible to recognize “clones” with a recent common ancestor. The distribution of variable numbers of tandem repeats types in the most common clone in the data set is incompatible with random mutation and drift. The most plausible explanation is a series of “clonal expansions,” and this interpretation is supported by the geographical distribution of different genotypes. We suggest that the clonal expansion of a genotype is caused either by the spread of a favorable mutation, together with all other genes present in the ancestral cell in which the mutation occurred, or by the invasion of a novel geographical region by a limited number of genotypes. A similar pattern is observed in M. tuberculosis (the main cause of tuberculosis in humans). The significance of clonal expansion in other bacteria that have recombination is discussed.
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Cites
Deciphering the biology of Mycobacterium tuberculosis from the complete genome sequence
Cole, S. T., Brosch, R., Parkhill, J., Garnier, T., Churcher, C., Harris, D., Gordon, S. V., Eiglmeier, K., Gas, S., Barry, C. E., et al. (1998) · Nature · doi:10.1038/31159 · Cited by 7,847
Self-citationSmith, J. M., Smith, N. H., O'Rourke, M., & Spratt, B. G. (1993) · Proceedings of the National Academy of Sciences · doi:10.1073/pnas.90.10.4384 · Cited by 1,802
Self-citation
Cited by
Ancient Origin and Gene Mosaicism of the Progenitor of Mycobacterium tuberculosis
Gutierrez, M. C., Brisse, S., Brosch, R., Fabre, M., Omaïs, B., Marmiesse, M., Supply, P., & Vincent, V. (2005) · PLoS Pathogens · doi:10.1371/journal.ppat.0010005 · Cited by 646
Genome plasticity of BCG and impact on vaccine efficacy
Brosch, R., Gordon, S. V., Garnier, T., Eiglmeier, K., Frigui, W., Valenti, P., Dos Santos, S., Duthoy, S., Lacroix, C., Garcia-Pelayo, C., et al. (2007) · Proceedings of the National Academy of Sciences · doi:10.1073/pnas.0700869104 · Cited by 574
Self-citationAnimal movements and the spread of infectious diseases
Fèvre, E. M., Bronsvoort, B. M. D. C., Hamilton, K. A., & Cleaveland, S. (2006) · Trends in Microbiology · doi:10.1016/j.tim.2006.01.004 · Cited by 498
Bottlenecks and broomsticks: the molecular evolution of Mycobacterium bovis
Smith, N. H., Gordon, S. V., de la Rua-Domenech, R., Clifton-Hadley, R. S., & Hewinson, R. G. (2006) · Nature Reviews Microbiology · doi:10.1038/nrmicro1472 · Cited by 375
Self-citationLindstedt, B. (2005) · ELECTROPHORESIS · doi:10.1002/elps.200500096 · Cited by 329
Metadata
- Authors
- Smith, N. H., Dale, J., Inwald, J., Palmer, S., Gordon, S. V., Hewinson, R. G., & Smith, J. M.
- Venue
- Proceedings of the National Academy of Sciences
- Published
- 2003-12
- Volume
- 100
- Issue
- 25
- Pages
- 15271-15275
- ISSN
- 0027-8424 (ISSN-L)
- 1091-6490
- OpenAlex
- W2044692417
- Cited by
- 158
- References
- 2
- FWCI
- 6.52
- Type
- journal article
- Language
- en
- Open access
- green
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- Smith, N. H., Dale, J., Inwald, J., Palmer, S., Gordon, S. V., Hewinson, R. G., & Smith, J. M. (2003). The population structure of Mycobacterium bovis in Great Britain: Clonal expansion. Proceedings of the National Academy of Sciences. https://doi.org/10.1073/pnas.2036554100
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