Deciphering the biology of Mycobacterium tuberculosis from the complete genome sequence

Cole, S. T.; Brosch, R.; Parkhill, J.; Garnier, T.; Churcher, C.; Harris, D.; Gordon, S. V.; Eiglmeier, K.; Gas, S.; Barry, C. E.; Tekaia, F.; Badcock, K.; Basham, D.; Brown, D.; Chillingworth, T.; Connor, R.; Davies, R.; Devlin, K.; Feltwell, T.; Gentles, S.; Hamlin, N.; Holroyd, S.; Hornsby, T.; Jagels, K.; Krogh, A.; McLean, J.; Moule, S.; Murphy, L.; Oliver, K.; Osborne, J.; Quail, M. A.; Rajandream, M.-A.; Rogers, J.; Rutter, S.; Seeger, K.; Skelton, J.; Squares, R.; Squares, S.; Sulston, J. E.; Taylor, K.; Whitehead, S.; Barrell, B. G.

doi:10.1038/31159

Cited by 7,847Tuberculosis Research and EpidemiologyGenomics and Phylogenetic StudiesMycobacterium research and diagnosis

Deciphering the biology of Mycobacterium tuberculosis from the complete genome sequence

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Cole, S. T., Brosch, R., Parkhill, J., Garnier, T., Churcher, C., Harris, D., Gordon, S. V., Eiglmeier, K. +34 more·1998·Nature

DOI 10.1038/31159

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Abstract

Countless millions of people have died from tuberculosis, a chronic infectious disease caused by the tubercle bacillus. The complete genome sequence of the best-characterized strain of Mycobacterium tuberculosis, H37Rv, has been determined and analysed in order to improve our understanding of the biology of this slow-growing pathogen and to help the conception of new prophylactic and therapeutic interventions. The genome comprises 4,411,529 base pairs, contains around 4,000 genes, and has a very high guanine + cytosine content that is reflected in the biased amino-acid content of the proteins. M. tuberculosis differs radically from other bacteria in that a very large portion of its coding capacity is devoted to the production of enzymes involved in lipogenesis and lipolysis, and to two new families of glycine-rich proteins with a repetitive structure that may represent a source of antigenic variation.

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The M. tuberculosis genome appears to encode multiple cell wall hydrolases.
“M. tuberculosis genome appears to contain several cell wall hydrolases.36”
From ChiZ levels modulate cell division process in mycobacteria (2011) · cites this paper as [36]
ESX/T7S systems were first discovered almost 20 years ago during in silico analyses of the genome sequence and proteome of M. tuberculosis H37Rv.
“which were first discovered almost 20 years ago during in silico analyses of the genome sequence and the proteome of Mycobacterium tuberculosis H37Rv (17,18).”
From ESX/Type VII Secretion Systems—An Important Way Out for Mycobacterial Proteins (2019) · cites this paper as [17]

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INVESTIGATION OF THE AMINO ACID SEQUENCES OF MYCOBACTERIUM TUBERCULOSIS COMPLETE GENOME WITH PROTEIN FAMILY PATTERNS BANK PROF_PAT 1.3
Ph, N. L., Kozhina, E. M., Yarigin, A. A., & G, B. A. (2015)

Authors: Cole, S. T., Brosch, R., Parkhill, J., Garnier, T., Churcher, C., Harris, D., Gordon, S. V., Eiglmeier, K., Gas, S., Barry, C. E., Tekaia, F., Badcock, K., Basham, D., Brown, D., Chillingworth, T., Connor, R., Davies, R., Devlin, K., Feltwell, T., Gentles, S., Hamlin, N., Holroyd, S., Hornsby, T., Jagels, K., Krogh, A., McLean, J., Moule, S., Murphy, L., Oliver, K., Osborne, J., Quail, M. A., Rajandream, M.-A., Rogers, J., Rutter, S., Seeger, K., Skelton, J., Squares, R., Squares, S., Sulston, J. E., Taylor, K., Whitehead, S., & Barrell, B. G.
Affiliations: Institut Pasteur (FR)
Wellcome Sanger Institute (GB)
National Institutes of Health (US)
Technical University of Denmark (DK)
Corresponding author: Barrell, B. G.
ORCID: Cole, S. T.
Brosch, R.
Parkhill, J.
Harris, D.
Gordon, S. V.
Eiglmeier, K.
Barry, C. E.
Tekaia, F.
Davies, R.
Feltwell, T.
Krogh, A.
Murphy, L.
Oliver, K.
Quail, M. A.
Venue: Nature
Publisher: Springer Science and Business Media LLC
Published: 1998-06
Volume: 393
Issue: 6685
Pages: 537-544
ISSN: 0028-0836 (ISSN-L)
1476-4687
DOI: 10.1038/31159
OpenAlex: W2158023121
Cited by: 7,847
References: 53
Citations by year: 2026: 124 · 2025: 173 · 2024: 157 · 2023: 209 · 2022: 188 · 2021: 233 · 2020: 220 · 2019: 235 · 2018: 259 · 2017: 257 · 2016: 259 · 2015: 312 · 2014: 385 · 2013: 340 · 2012: 318
FWCI: 249.58
Type: journal article
Language: en
Open access: bronze
doi.org
Licence: www.springer.com/tdm (tdm)
www.springer.com/tdm (vor)
Locations: Nature (publishedVersion)
PubMed (publishedVersion)
Research Explorer (The University of Manchester) (publishedVersion)
RePEc: Research Papers in Economics (submittedVersion)
Infoscience (Ecole Polytechnique Fédérale de Lausanne) (submittedVersion)
Infoscience (Ecole Polytechnique Fédérale de Lausanne) (submittedVersion, cc-by-nc-nd)
Funders: American Heart Association
Wellcome Trust
Medical Research Council Canada
National Institutes of Health
Medical Research Council
National Institute of Allergy and Infectious Diseases (Z01AI000783)
Brookhaven National Laboratory
Topics: Health Sciences › Medicine › Infectious Diseases › Tuberculosis Research and Epidemiology
Life Sciences › Biochemistry, Genetics and Molecular Biology › Molecular Biology › Genomics and Phylogenetic Studies
Health Sciences › Medicine › Epidemiology › Mycobacterium research and diagnosis
Keywords: Mycobacterium tuberculosis, Mycobacterium tuberculosis H37Rv, complete genome sequence, genome analysis, GC content, amino acid composition, lipogenesis, lipolysis, glycine-rich proteins, antigenic variation, tuberculosis pathogenesis, tuberculosis treatment
MeSH terms: Chromosome Mapping, Chromosomes, Bacterial, Drug Resistance, Microbial, Humans, Molecular Sequence Data, Mycobacterium tuberculosis, Tuberculosis, Genome, Bacterial, Sequence Analysis, DNA, Lipid Metabolism

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Deciphering the biology of Mycobacterium tuberculosis from the complete genome sequence

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