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Protection of the intestinal mucosa by intraepithelial γδ T cells
Open accessAbstract
γδ intraepithelial T lymphocytes (IEL) represent a major T cell population within the intestine of unclear functional relevance. The role of intestinal γδ IEL was evaluated in the dextran sodium sulfate (DSS) induced mouse colitis model system. Large numbers of γδ T cells, but not αβ T cells, were localized at sites of DSS-induced epithelial cell damage. γδ IEL in DSS treated mice expressed keratinocyte growth factor (KGF), a potent intestinal epithelial cell mitogen. γδ cell-deficient mice (TCRδ−/−) and KGF-deficient mice (KGF−/−), but not αβ cell-deficient mice (TCRα−/−), were more prone than wild-type mice to DSS-induced mucosal injury and demonstrated delayed tissue repair after termination of DSS treatment. Termination of DSS treatment resulted in vigorous epithelial cell proliferation in wild-type mice but not in TCRδ−/−mice or KGF−/−mice. These results suggest that γδ IEL help preserve the integrity of damaged epithelial surfaces by providing the localized delivery of an epithelial cell growth factor.
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Cites
γδ T cells: functional plasticity and heterogeneity
Carding, S. R., & Egan, P. J. (2002) · Nature Reviews Immunology · doi:10.1038/nri797 · Cited by 814
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γδ T cell effector functions: a blend of innate programming and acquired plasticity
Bonneville, M., O'Brien, R. L., & Born, W. K. (2010) · Nature Reviews Immunology · doi:10.1038/nri2781 · Cited by 952
The light and dark sides of intestinal intraepithelial lymphocytes
Cheroutre, H., Lambolez, F., & Mucida, D. (2011) · Nature Reviews Immunology · doi:10.1038/nri3007 · Cited by 693
Rombout, J. H. W. M., Abelli, L., Picchietti, S., Scapigliati, G., & Kiron, V. (2011) · Fish & Shellfish Immunology · doi:10.1016/j.fsi.2010.09.001 · Cited by 608
Mouse models of inflammatory bowel disease☆
WIRTZ, S., & NEURATH, M. (2007) · Advanced Drug Delivery Reviews · doi:10.1016/j.addr.2007.07.003 · Cited by 507
Metadata
- Authors
- Chen, Y., Chou, K., Fuchs, E., Havran, W. L., & Boismenu, R.
- Venue
- Proceedings of the National Academy of Sciences
- Published
- 2002-10-10
- Volume
- 99
- Issue
- 22
- Pages
- 14338-14343
- ISSN
- 0027-8424 (ISSN-L)
- 1091-6490
- OpenAlex
- W2053388673
- Cited by
- 480
- References
- 1
- FWCI
- 8.17
- Type
- journal article
- Language
- en
- Open access
- green
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- Chen, Y., Chou, K., Fuchs, E., Havran, W. L., & Boismenu, R. (2002). Protection of the intestinal mucosa by intraepithelial γδ T cells. Proceedings of the National Academy of Sciences. https://doi.org/10.1073/pnas.212290499
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Contains information from the Semantic Scholar Academic Graph Datasets, made available under the ODC Attribution License (ODC-BY 1.0).
Semantic Scholar’s data is described in: Kinney, R., et al. (2023). The Semantic Scholar Open Data Platform. arXiv:2301.10140.
