γδ T cell effector functions: a blend of innate programming and acquired plasticity
Abstract
Gammadelta T cells have several innate cell-like features that allow their early activation following recognition of conserved stress-induced ligands. Here we review recent observations revealing the ability of gammadelta T cells to rapidly produce cytokines that regulate pathogen clearance, inflammation and tissue homeostasis in response to tissue stress. These studies provide insights into how they acquire these properties, through both developmental programming in the thymus and functional polarization in the periphery. Innate features of gammadelta T cells underlie their non-redundant role in several physiopathological contexts and are therefore being exploited in the design of new immunotherapeutic approaches.
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Experiments in mice have demonstrated that γδ T cells are predominantly tissue-resident immune cells.
“Experiments in mice have demonstrated that γδ T cells are predominantly tissue-resident immune cells (6, 7).”
From Comparing Mouse and Human Tissue-Resident γδ T Cells (2022) · cites this paper as [7]
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- Authors
- Bonneville, M., O'Brien, R. L., & Born, W. K.
- Affiliations
- Inserm (FR)
- National Jewish Health (US)
- Corresponding author
- Bonneville, Marc
- Born, Willi K.
- Venue
- Nature Reviews Immunology
- Published
- 2010-06-11
- Volume
- 10
- Issue
- 7
- Pages
- 467-478
- ISSN
- 1474-1733 (ISSN-L)
- 1474-1741
- OpenAlex
- W1995930566
- Cited by
- 952
- References
- 5
- Citations by year
- 2026: 23 · 2025: 43 · 2024: 45 · 2023: 42 · 2022: 53 · 2021: 77 · 2020: 72 · 2019: 70 · 2018: 63 · 2017: 69 · 2016: 41 · 2015: 56 · 2014: 82 · 2013: 67 · 2012: 79
- FWCI
- 5.48
- Type
- journal article
- Language
- en
- Open access
- closed
- Locations
- Nature reviews. Immunology (publishedVersion)
- PubMed (publishedVersion)
- Topics
- Life Sciences › Immunology and Microbiology › Immunology › T-cell and B-cell Immunology
- Life Sciences › Immunology and Microbiology › Immunology › Immune Cell Function and Interaction
- Life Sciences › Immunology and Microbiology › Immunology › Psoriasis: Treatment and Pathogenesis
- Keywords
- γδ T cells, effector function, innate immunity, thymus development, periphery, polarization, stress-induced ligands, cytokine production, cytotoxicity, tissue homeostasis, inflammation, immunotherapy
- MeSH terms
- Animals, B-Lymphocytes, Humans, Immunity, Innate, Immunotherapy, Infections, Lymphocyte Cooperation, Lymphocyte Activation, Stress, Physiological, Signal Transduction, T-Lymphocyte Subsets, Cytokines, Receptors, Antigen, T-Cell, gamma-delta, Models, Immunological, Mice
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