Reduction of embryonic E93 expression as a hypothetical driver of the evolution of insect metamorphosis
Open accessAbstract
The early embryo of the cockroach Blattella germanica exhibits high E93 expression. In general, E93 triggers adult morphogenesis during postembryonic development. Here we show that E93 is also crucial in early embryogenesis in the cockroach, as a significant number of E93-depleted embryos are unable to develop the germ band under maternal RNAi treatment targeting E93 . Moreover, transcriptomic analysis indicates that E93 depletion results in important gene expression changes in the early embryo, and many of the differentially expressed genes are involved in development. Then, using public databases, we gathered E93 expression data in embryo and preadult stages, finding that embryonic expression of E93 is high in hemimetabolan species (whose juveniles, or nymphs, are similar to the adult) and low in holometabolans (whose juveniles, or larvae, are different from the adult). E93 expression is also low in Thysanoptera and in Hemiptera Sternorrhyncha, hemimetabolans with postembryonic quiescent stages, as well as in Odonata, the nymph of which is very different from the adult. In ametabolans, such as the Zygentoma Thermobia domestica , E93 transcript levels are very high in the early embryo, whereas during postembryonic development they are medium and relatively constant. We propose the hypothesis that during evolution, a reduction of E93 expression in the embryo of hemimetabolans facilitated the larval development and the emergence of holometaboly. Independent decreases of E93 transcripts in the embryo of Odonata, Thysanoptera, and different groups of Hemiptera Sternorrhyncha would have allowed the development of modified juvenile stages adapted to specific ecophysiological conditions.
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broad expression is maintained by juvenile hormone.
“Like chinmo [43], broad expression is maintained by JH [18].”
From Regulation of metamorphosis in holometabolous insects (2026) · cites this paper as [18]
The Results and Discussion section on embryonic E93 expression reports that Kr-h1 is JH-dependent and describes the expression pattern of Broad complex (Br-C), but does not say JH maintains Br-C expression. Searches for Broad/Br-C expression and juvenile hormone found no passage establishing that relationship; page numbers were not available in our copy. (LLM, conf=0.76)
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Truman, J. W., & Riddiford, L. M. (2022) · Proceedings of the National Academy of Sciences · doi:10.1073/pnas.2201071119 · Cited by 53 · see citing works
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Research works printed but not linked: 26
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Regulation of metamorphosis in holometabolous insects
Truman, J. W., & Riddiford, L. M. (2026) · Current Opinion in Insect Science · doi:10.1016/j.cois.2026.101508 · Cited by 6 · see citing works
- Authors
- Fernandez-Nicolas, A., Machaj, G., Ventos-Alfonso, A., Pagone, V., Minemura, T., Ohde, T., Daimon, T., Ylla, G., & Belles, X.
- Affiliations
- Institute of Evolutionary Biology, Spanish National Research Council (CSIC)-Universitat Pompeu Fabra, Barcelona 08003, Spain
- Jagiellonian University (PL)
- Consejo Superior de Investigaciones Científicas (ES)
- Kyoto University (JP)
- Corresponding author
- Ylla, Guillem
- ORCID
- Venue
- Proceedings of the National Academy of Sciences
- Publisher
- National Academy of Sciences
- Published
- 2023-02-06
- Volume
- 120
- Issue
- 7
- Pages
- e2216640120-e2216640120
- ISSN
- 0027-8424 (ISSN-L)
- 1091-6490
- PMC
- PMC9963766
- OpenAlex
- W4319303654
- Cited by
- 37
- References
- 1
- Citations by year
- 2026: 12 · 2025: 5 · 2024: 13 · 2023: 6 · 2022: 1
- FWCI
- 3.21
- Type
- journal article
- Language
- en
- Open access
- hybrid
- doi.org
- Licence
- Locations
- Proceedings of the National Academy of Sciences (publishedVersion, cc-by-nc-nd)
- PubMed Central (publishedVersion, cc-by-nc-nd)
- PubMed (publishedVersion)
- Jagiellonian University Repository (Jagiellonian University) (submittedVersion, cc-by-nc-nd)
- DIGITAL.CSIC (Spanish National Research Council (CSIC)) (submittedVersion, cc-by-nc-nd)
- Funders
- MEC | Agencia Estatal de Investigación (PID2019-104483 GB-I00 / AEI / 10.13039/501100011033, CGL2015‐64727‐P, CGL2012‐36251)
- Government of Catalonia | Comissió Interdepartamental de Recerca i Innovació Tecnològica (2017 SGR 1030)
- EC | European Regional Development Fund (--)
- Ministry of Education, Culture, Sports, Science and Technology (KAKENHI 20H02999, KAKENHI 17H03943)
- Topics
- Life Sciences › Biochemistry, Genetics and Molecular Biology › Molecular Biology › Developmental Biology and Gene Regulation
- Life Sciences › Neuroscience › Cellular and Molecular Neuroscience › Neurobiology and Insect Physiology Research
- Life Sciences › Biochemistry, Genetics and Molecular Biology › Genetics › Insect and Arachnid Ecology and Behavior
- Keywords
- E93, Blattella germanica, insect metamorphosis, holometabolism, hemimetabolism, embryonic development, embryonic gene expression, insect evolution, Odonata, Thysanoptera, Zygentoma, Thermobia domestica, postembryonic development
- MeSH terms
- Animals, Hemiptera, Insecta, Larva, Metamorphosis, Biological, Gene Expression Regulation, Developmental, Insect Proteins, RNA Interference
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