The DOI matches its Crossref record; 30 of the 30 references it cites were found in a registry or an index.
Potentiation of serum response factor activity by a family of myocardin-related transcription factors
Open accessAbstract
Myocardin is a SAP (SAF-A/B, Acinus, PIAS) domain transcription factor that associates with serum response factor (SRF) to potently enhance SRF-dependent transcription. Here we describe two myocardin-related transcription factors (MRTFs), A and B, that also interact with SRF and stimulate its transcriptional activity. Whereas myocardin is expressed specifically in cardiac and smooth muscle cells, MRTF-A and -B are expressed in numerous embryonic and adult tissues. In SRF-deficient embryonic stem cells, myocardin and MRTFs are unable to activate SRF-dependent reporter genes, confirming their dependence on SRF. Myocardin and MRTFs comprise a previously uncharacterized family of SRF cofactors with the potential to modulate SRF target genes in a wide range of tissues.
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Guan, K., & Dixon, J. E. (1991) · Analytical Biochemistry · doi:10.1016/0003-2697(91)90534-z · Cited by 1,746
The Rho family GTPases RhoA, Racl , and CDC42Hsregulate transcriptional activation by SRF
Hill, C. S., Wynne, J., & Treisman, R. (1995) · Cell · doi:10.1016/s0092-8674(05)80020-0 · Cited by 1,269
Norman, C., Runswick, M., Pollock, R., & Treisman, R. (1988) · Cell · doi:10.1016/0092-8674(88)90244-9 · Cited by 957
Wang, D.-Z., Chang, P. S., Wang, Z., Sutherland, L., Richardson, J. A., Small, E., Krieg, P. A., & Olson, E. N. (2001) · Cell · doi:10.1016/s0092-8674(01)00404-4 · Cited by 898
Self-citationInhibition of Stat1-mediated gene activation by PIAS1
Liu, B., Liao, J., Rao, X., Kushner, S. A., Chung, C. D., Chang, D. D., & Shuai, K. (1998) · Proceedings of the National Academy of Sciences · doi:10.1073/pnas.95.18.10626 · Cited by 765
Ternary complex factors: growth factor regulated transcriptional activators
Treisman, R. (1994) · Current Opinion in Genetics & Development · doi:10.1016/0959-437x(94)90097-3 · Cited by 676
Dalton, S., & Treisman, R. (1992) · Cell · doi:10.1016/0092-8674(92)90194-h · Cited by 672
Tbx5 associates with Nkx2-5 and synergistically promotes cardiomyocyte differentiation
Hiroi, Y., Kudoh, S., Monzen, K., Ikeda, Y., Yazaki, Y., Nagai, R., & Komuro, I. (2001) · Nature Genetics · doi:10.1038/90123 · Cited by 599
Activation of ternary complex factor Elk-1 by MAP kinases.
Janknecht, R., Ernst, W. H., Pingoud, V., & Nordheim, A. (1993) · The EMBO Journal · doi:10.1002/j.1460-2075.1993.tb06204.x · Cited by 560
Self-citationSachdev, S., Bruhn, L., Sieber, H., Pichler, A., Melchior, F., & Grosschedl, R. (2001) · Genes & Development · doi:10.1101/gad.944801 · Cited by 547
Cited by
Actin dynamics control SRF activity by regulation of its coactivator MAL
Miralles, F., Posern, G., Zaromytidou, A.-I., & Treisman, R. (2003) · Cell · doi:10.1016/s0092-8674(03)00278-2 · Cited by 1,327
Linking actin dynamics and gene transcription to drive cellular motile functions
Olson, E. N., & Nordheim, A. (2010) · Nature Reviews Molecular Cell Biology · doi:10.1038/nrm2890 · Cited by 958
Self-citationMessenguy, F., & Dubois, E. (2003) · Gene · doi:10.1016/s0378-1119(03)00747-9 · Cited by 304
Morita, T., Mayanagi, T., & Sobue, K. (2007) · The Journal of Cell Biology · doi:10.1083/jcb.200708174 · Cited by 262
Velasquez, L. S., Sutherland, L. B., Liu, Z., Grinnell, F., Kamm, K. E., Schneider, J. W., Olson, E. N., & Small, E. M. (2013) · Proceedings of the National Academy of Sciences · doi:10.1073/pnas.1316764110 · Cited by 142
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Metadata
- Authors
- Wang, D.-Z., Li, S., Hockemeyer, D., Sutherland, L., Wang, Z., Schratt, G., Richardson, J. A., Nordheim, A., & Olson, E. N.
- Venue
- Proceedings of the National Academy of Sciences
- Published
- 2002-10-23
- Volume
- 99
- Issue
- 23
- Pages
- 14855-14860
- ISSN
- 0027-8424 (ISSN-L)
- 1091-6490
- OpenAlex
- W2152376785
- Cited by
- 474
- References
- 30
- FWCI
- 7.13
- Type
- journal article
- Language
- en
- Open access
- green
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