The DOI matches its Crossref record; 1 of the 1 references it cites were found in a registry or an index.
Tbx5 associates with Nkx2-5 and synergistically promotes cardiomyocyte differentiation
Overview
The claims and statistics of this paper haven’t been checked yet.
Run the check — free, no account needed. It reads the open-access text and checks the sources it cites.
Integrity signals
Registry
Cites
Statistics
Verification
Claims the paper makes
The claims and statistics of this paper haven’t been checked yet.
Run the check — free, no account needed. It reads the open-access text and checks the sources it cites.
Self-check
Percentages, sums and reported differences re-computed from the paper’s own numbers.
The self-check needs the paper’s full text.
Citations
Cites
Mutations in the cardiac transcription factor NKX2.5 affect diverse cardiac developmental pathways
Benson, D. W., Silberbach, G. M., Kavanaugh-McHugh, A., Cottrill, C., Zhang, Y., Riggs, S., Smalls, O., Johnson, M. C., Watson, M. S., Seidman, J. G., et al. (1999) · Journal of Clinical Investigation · doi:10.1172/jci8154 · Cited by 690
Research works printed but not linked: 28
- Komuro, I. & Izumo, S. Csx: a murine homeobox-containing gene specifically expressed in the developing heart. Proc. Natl. Acad. Sci. USA 90, 8145–8149 (1993). · DOI · Paper page
- Lints, T.J., Parsons, L.M., Hartley, L., Lyons, I. & Harvey, R.P. Nkx-2.5: a novel murine homeobox gene expressed in early heart progenitor cells and their myogenic descendants. Development 119, 419–431 (1993). · DOI · Paper page
- Lyons, I. et al. Myogenic and morphogenetic defects in the heart tubes of murine embryos lacking the homeobox gene Nkx2-5. Genes Dev. 9, 1654–1666 (1995). · DOI · Paper page
- Schott, J.J. et al. Congenital heart disease caused by mutations in the transcription factor NKX2-5. Science 281, 108–111 (1998). · DOI · Paper page
- Li, Q.Y. et al. Holt-Oram syndrome is caused by mutations in TBX5, a member of the Brachyury (T) gene family. Nature Genet. 15, 21–29 (1997). · DOI · Paper page
- Basson, C.T. et al. Mutations in human TBX5 cause limb and cardiac malformation in Holt-Oram syndrome. Nature Genet. 15, 30–35 (1997). · DOI · Paper page
- Basson, C.T. et al. Different TBX5 interactions in heart and limb defined by Holt-Oram syndrome mutations. Proc. Natl. Acad. Sci. USA 96, 2919–2924 (1999). · DOI · Paper page
- Habara-Ohkubo, A. Differentiation of beating cardiac muscle cells from a derivative of P19 embryonal carcinoma cells. Cell Struct. Funct. 21, 101–110 (1996). · doi:10.1247/csf.21.101
- Monzen, K. et al. Bone morphogenetic proteins induce cardiomyocyte differentiation through the mitogen-activated protein kinase kinase kinase TAK1 and cardiac transcription factors Csx/Nkx-2.5 and GATA-4. Mol. Cell. Biol. 19, 7096–7105 (1999). · DOI · Paper page
- Bodmer, R. The gene tinman is required for specification of the heart and visceral muscles in Drosophila. Development 118, 719–729 (1993). · DOI · Paper page
- Azpiazu, N. & Frasch, M. Tinman and bagpipe: two homeo box genes that determine cell fates in the dorsal mesoderm of Drosophila. Genes Dev. 7, 1325–1340 (1993). · DOI · Paper page
- Tanaka, M. et al. Vertebrate homologs of tinman and bagpipe: roles of the homeobox genes in cardiovascular development. Dev. Genet. 22, 239–249 (1998). · doi:10.1002/(sici)1520-6408(1998)22:3<239::aid-dvg6>3.0.co;2-7
- Tanaka, M., Chen, Z., Bartunkova, S., Yamasaki, N. & Izumo, S. The cardiac homeobox gene Csx/Nkx2.5 lies genetically upstream of multiple genes essential for heart development. Development 126, 1269–1280 (1999). · DOI · Paper page
- Kasahara, H. et al. Loss of function and inhibitory effects of human CSX/NKX2.5 homeoprotein mutations associated with congenital heart disease. J. Clin. Invest. 106, 299–308 (2000). · DOI · Paper page
- Hosoda, T. et al. Familial atrial septal defect and atrioventricular conduction disturbance associated with a point mutation in the cardiac homeobox gene CSX/NKX2-5 in a Japanese patient. Jpn. Circ. J. 63, 425–426 (1999). · DOI
- Chen, C.Y. et al. Activation of the cardiac alpha-actin promoter depends upon serum response factor, Tinman homologue, Nkx-2.5, and intact serum response elements. Dev. Genet. 19, 119–130 (1996). · doi:10.1002/(sici)1520-6408(1996)19:2<119::aid-dvg3>3.0.co;2-c
- Skerjanc, I.S., Petropoulos, H., Ridgeway, A.G. & Wilton, S. Myocyte enhancer factor 2C and Nkx2-5 up-regulate each other's expression and initiate cardiomyogenesis in P19 cells. J. Biol. Chem. 273, 34904–34910 (1998). · doi:10.1074/jbc.273.52.34904
- Durocher, D., Charron, F., Warren, R., Schwartz, R.J. & Nemer, M. The cardiac transcription factors Nkx2-5 and GATA-4 are mutual cofactors. EMBO J. 16, 5687–5696 (1997). · DOI · Paper page
- Lee, Y. et al. The cardiac tissue-restricted homeobox protein Csx/Nkx2.5 physically associates with the zinc finger protein GATA4 and cooperatively activates atrial natriuretic factor gene expression. Mol. Cell. Biol. 18, 3120–3129 (1998). · DOI · Paper page
- Shiojima, I. et al. Context-dependent transcriptional cooperation mediated by cardiac transcription factors Csx/Nkx-2.5 and GATA-4. J. Biol. Chem. 274, 8231–8239 (1999). · DOI
- Smith, J. T-box genes: what they do and how they do it. Trends Genet. 15, 154–158 (1999). · DOI · Paper page
- Gibson-Brown, J.J., Agulnik, S.I., Silver, L.M., Niswander, L. & Papaioannou, V.E. Involvement of T-box genes Tbx2-Tbx5 in vertebrate limb specification and development. Development 125, 2499–2509 (1998). · DOI · Paper page
- Takeuchi, J.K. et al. Tbx5 and Tbx4 genes determine the wing/leg identity of limb buds. Nature 398, 810–814 (1999). · DOI · Paper page
- Rodriguez-Esteban, C. et al. The T-box genes Tbx4 and Tbx5 regulate limb outgrowth and identity. Nature 398, 814–818 (1999). · DOI · Paper page
- Horb, M.E. & Thomsen, G.H. Tbx5 is essential for heart development. Development 126, 1739–1751 (1999). · DOI · Paper page
- Koshiba-Takeuchi, K. et al. Tbx5 and the retinotectum projection. Science 287, 134–137 (2000). · DOI · Paper page
- Muller, C.W. & Herrmann, B.G. Crystallographic structure of the T domain-DNA complex of the Brachyury transcription factor. Nature 389, 884–888 (1997). · DOI · Paper page
- Liberatore, C.M., Searcy-Schrick, R.D. & Yutzey, K.E. Ventricular expression of Tbx5 inhibits normal heart chamber development. Dev. Biol. 223, 169–180 (2000). · DOI · Paper page
Cited by
The developmental genetics of congenital heart disease
Bruneau, B. G. (2008) · Nature · doi:10.1038/nature06801 · Cited by 687
Wang, D.-Z., Li, S., Hockemeyer, D., Sutherland, L., Wang, Z., Schratt, G., Richardson, J. A., Nordheim, A., & Olson, E. N. (2002) · Proceedings of the National Academy of Sciences · doi:10.1073/pnas.222561499 · Cited by 474
The transcriptional repressor Tbx3 delineates the developing central conduction system of the heart
HOOGAARS, W. (2004) · Cardiovascular Research · doi:10.1016/j.cardiores.2004.01.030 · Cited by 339
Cooperative and antagonistic interactions between Sall4 and Tbx5 pattern the mouse limb and heart
Koshiba-Takeuchi, K., Takeuchi, J. K., Arruda, E. P., Kathiriya, I. S., Mo, R., Hui, C.-C., Srivastava, D., & Bruneau, B. G. (2006) · Nature Genetics · doi:10.1038/ng1707 · Cited by 170
Lingbeek, M. E., Jacobs, J. J. L., & van Lohuizen, M. (2002) · Journal of Biological Chemistry · doi:10.1074/jbc.m200403200 · Cited by 160
Metadata
- Authors
- Hiroi, Y., Kudoh, S., Monzen, K., Ikeda, Y., Yazaki, Y., Nagai, R., & Komuro, I.
- Venue
- Nature Genetics
- Published
- 2001-07
- Volume
- 28
- Issue
- 3
- Pages
- 276-280
- ISSN
- 1061-4036 (ISSN-L)
- 1546-1718
- OpenAlex
- W1602684793
- Cited by
- 599
- References
- 1
- FWCI
- 12.70
- Type
- journal article
- Language
- en
- Open access
- closed
- Licence
- www.springer.com/tdm (tdm)
About these checks
Registry, retraction, Cites and statistics results are computed, not judged, with one exception: a printed reference that no index lists is read once by a model before it counts as a citation error. Claims are extracted by a model and kept only when their quote appears verbatim in the text; each cited source is then checked, with a model’s help, for whether it says what the claim relies on. Those verdicts can be wrong — read the claim’s quote and the cited source before relying on one.
Statistics and arithmetic are recomputed, not judged.
Confidence bands are shown only for fields calibrated on our annotated test set. None is calibrated yet, so no band is shown.
What counts as a claim ›How we measure confidence ›How we check this ›
Are you an author, or do you see a problem with this page? Request a review
How to cite
Cite CoChat for the checks on this page, and the paper for its own findings.
- This page
- CoChat. (2026). Citation check: Tbx5 associates with Nkx2-5 and synergistically promotes cardiomyocyte differentiation. https://app.cochat.ai/papers/10.1038/90123
- The paper
- Hiroi, Y., Kudoh, S., Monzen, K., Ikeda, Y., Yazaki, Y., Nagai, R., & Komuro, I. (2001). Tbx5 associates with Nkx2-5 and synergistically promotes cardiomyocyte differentiation. Nature Genetics. https://doi.org/10.1038/90123
Data sources
Bibliographic data: Semantic Scholar, OpenAlex, Crossref.
Contains information from the Semantic Scholar Academic Graph Datasets, made available under the ODC Attribution License (ODC-BY 1.0).
Semantic Scholar’s data is described in: Kinney, R., et al. (2023). The Semantic Scholar Open Data Platform. arXiv:2301.10140.
