Sex-specific and opposed effects of FKBP51 in glutamatergic and GABAergic neurons: Implications for stress susceptibility and resilience

van Doeselaar, Lotte; Stark, Tibor; Mitra, Shiladitya; Yang, Huanqing; Bordes, Joeri; Stolwijk, Linda; Engelhardt, Clara; Kovarova, Veronika; Narayan, Sowmya; Brix, Lea M.; Springer, Margherita; Deussing, Jan M.; Lopez, Juan Pablo; Czisch, Michael; Schmidt, Mathias V.

doi:10.1073/pnas.2300722120

Sex-specific and opposed effects of FKBP51 in glutamatergic and GABAergic neurons: Implications for stress susceptibility and resilience

Mental health disorders often arise as a combination of environmental and genetic factors. The FKBP5 gene, encoding the GR co-chaperone FKBP51, has been uncovered as a key genetic risk factor for stress-related illness. However, the exact cell type and region-specific mechanisms by which FKBP51 c…