The DOI matches its Crossref record; 31 of the 31 references it cites were found in a registry or an index.
Expression of Borrelia burgdorferi OspC and DbpA is controlled by a RpoN–RpoS regulatory pathway
Open accessAbstract
RpoS and RpoN are two alternative sigma factors typically associated with general stress responses in bacteria. To date, there has been no experimental evidence that RpoS and RpoN can directly control the expression of one another. Herein, using a combined strategy of gene disruption and genetic complementation targeting rpoN and rpoS in Borrelia burgdorferi strain 297, we describe a regulatory network for B. burgdorferi . In this network, RpoN controls the expression of RpoS, which, in turn, governs the expression of two important membrane lipoproteins, outer surface protein C and decorin-binding protein A, and likely other proteins of B. burgdorferi . Our findings provide a foundation for elucidating further key regulatory networks that potentially impact many aspects of B. burgdorferi 's parasitic strategy, host range, and virulence expression.
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Cited by
Steere, A. C., Strle, F., Wormser, G. P., Hu, L. T., Branda, J. A., Hovius, J. W. R., Li, X., & Mead, P. S. (2016) · Nature Reviews Disease Primers · doi:10.1038/nrdp.2016.90 · Cited by 845
Of ticks, mice and men: understanding the dual-host lifestyle of Lyme disease spirochaetes
Radolf, J. D., Caimano, M. J., Stevenson, B., & Hu, L. T. (2012) · Nature Reviews Microbiology · doi:10.1038/nrmicro2714 · Cited by 745
Aguero-Rosenfeld, M. E., Wang, G., Schwartz, I., & Wormser, G. P. (2005) · Clinical Microbiology Reviews · doi:10.1128/cmr.18.3.484-509.2005 · Cited by 744
Zoonotic Potential of the Microsporidia
Mathis, A., Weber, R., & Deplazes, P. (2005) · Clinical Microbiology Reviews · doi:10.1128/cmr.18.3.423-445.2005 · Cited by 474
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Self-citation
Metadata
- Authors
- Hübner, A., Yang, X., Nolen, D. M., Popova, T. G., Cabello, F. C., & Norgard, M. V.
- Venue
- Proceedings of the National Academy of Sciences
- Published
- 2001-10-23
- Volume
- 98
- Issue
- 22
- Pages
- 12724-12729
- ISSN
- 0027-8424 (ISSN-L)
- 1091-6490
- OpenAlex
- W1986984168
- Cited by
- 335
- References
- 31
- FWCI
- 11.59
- Type
- journal article
- Language
- en
- Open access
- green
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- Hübner, A., Yang, X., Nolen, D. M., Popova, T. G., Cabello, F. C., & Norgard, M. V. (2001). Expression of Borrelia burgdorferi OspC and DbpA is controlled by a RpoN–RpoS regulatory pathway. Proceedings of the National Academy of Sciences. https://doi.org/10.1073/pnas.231442498
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Contains information from the Semantic Scholar Academic Graph Datasets, made available under the ODC Attribution License (ODC-BY 1.0).
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