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Lyme Borreliosis in Selected Strains and Ages of Laboratory Mice
Abstract
The susceptibility of laboratory mice to Borrelia burgdorferi was evaluated for selected genotypes and ages. C3H/He, SWR, C57BL/6, SJL, and BALB/c mice inoculated at age 3 days developed uniformly severe polyarthritis at 30 days after intraperitoneal inoculation. Mice inoculated at age 3 weeks also developed polyarthritis, but severity was influenced by genotype, with C3H/He and SWR mice the most severely affected. Susceptible strains developed higher IgG ELISA antibody titers to B. burgdorferi than did resistant mice. Adult (12 weeks) C3H/He mice were also susceptible, but arthritis was not as severe as in those inoculated at age 3 weeks. SKH (hairless) mice developed polyarthritis but not skin disease when inoculated intradermally. Carditis occurred frequently among C3H/He, BALB/c, and hairless mice and in some SWR mice but not in C57BL/6 or SJL mice. This study demonstrates that severity of Lyme borreliosis is age- and genotype-dependent and that laboratory mice are a potentially valuable model.
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Cited by
Steere, A. C., Strle, F., Wormser, G. P., Hu, L. T., Branda, J. A., Hovius, J. W. R., Li, X., & Mead, P. S. (2016) · Nature Reviews Disease Primers · doi:10.1038/nrdp.2016.90 · Cited by 845
Protection of Mice Against the Lyme Disease Agent by Immunizing with Recombinant OspA
Fikrig, E., Barthold, S. W., Kantor, F. S., & Flavell, R. A. (1990) · Science · doi:10.1126/science.2237407 · Cited by 488
Self-citationExpression of Borrelia burgdorferi OspC and DbpA is controlled by a RpoN–RpoS regulatory pathway
Hübner, A., Yang, X., Nolen, D. M., Popova, T. G., Cabello, F. C., & Norgard, M. V. (2001) · Proceedings of the National Academy of Sciences · doi:10.1073/pnas.231442498 · Cited by 335
Revel, A. T., Talaat, A. M., & Norgard, M. V. (2002) · Proceedings of the National Academy of Sciences · doi:10.1073/pnas.032667699 · Cited by 332
Ritzman, A. M., Hughes-Hanks, J. M., Blaho, V. A., Wax, L. E., Mitchell, W. J., & Brown, C. R. (2010) · Infection and Immunity · doi:10.1128/iai.00798-10 · Cited by 123
Metadata
- Authors
- Barthold, S. W., Beck, D. S., Hansen, G. M., Terwilliger, G. A., & Moody, K. D.
- Venue
- Journal of Infectious Diseases
- Publisher
- Oxford University Press (OUP)
- Published
- 1990-07-01
- Volume
- 162
- Issue
- 1
- Pages
- 133-138
- ISSN
- 0022-1899 (ISSN-L)
- 1537-6613
- OpenAlex
- W2150034821
- Cited by
- 446
- References
- 0
- FWCI
- 14.26
- Type
- journal article
- Language
- en
- Open access
- closed
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- CoChat. (2026). Citation check: Lyme Borreliosis in Selected Strains and Ages of Laboratory Mice. https://app.cochat.ai/papers/10.1093/infdis/162.1.133
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- Barthold, S. W., Beck, D. S., Hansen, G. M., Terwilliger, G. A., & Moody, K. D. (1990). Lyme Borreliosis in Selected Strains and Ages of Laboratory Mice. Journal of Infectious Diseases. https://doi.org/10.1093/infdis/162.1.133
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Contains information from the Semantic Scholar Academic Graph Datasets, made available under the ODC Attribution License (ODC-BY 1.0).
Semantic Scholar’s data is described in: Kinney, R., et al. (2023). The Semantic Scholar Open Data Platform. arXiv:2301.10140.
