The DOI matches its Crossref record; 3 of the 3 references it cites were found in a registry or an index.
Membrane cholesterol, lateral mobility, and the phosphatidylinositol 4,5-bisphosphate-dependent organization of cell actin
Open accessAbstract
Responses to cholesterol depletion are often taken as evidence of a role for lipid rafts in cell function. Here, we show that depletion of cell cholesterol has global effects on cell and plasma membrane architecture and function. The lateral mobility of membrane proteins is reduced when cell cholesterol is chronically or acutely depleted. The change in mobility is a consequence of the reorganization of the cell actin. Binding of a GFP-tagged pleckstrin homology domain specific for phosphatidylinositol 4,5-bisphosphate [PI(4,5)P2] to the plasma membrane is reduced after cholesterol depletion. This result implies that the reorganization of cytoskeleton depends on the loss or redistribution of plasma membrane PI(4,5)P2. Consistent with this observation, agents that sequester plasma membrane PI(4,5)P2 mimic the effects of cholesterol depletion on actin organization and on lateral mobility.
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Cites
PIP2and Proteins: Interactions, Organization, and Information Flow
McLaughlin, S., Wang, J., Gambhir, A., & Murray, D. (2002) · Annual Review of Biophysics and Biomolecular Structure · doi:10.1146/annurev.biophys.31.082901.134259 · Cited by 837
Raucher, D., Stauffer, T., Chen, W., Shen, K., Guo, S., York, J. D., Sheetz, M. P., & Meyer, T. (2000) · Cell · doi:10.1016/s0092-8674(00)81560-3 · Cited by 675
Self-citationPike, L. J., & Miller, J. M. (1998) · Journal of Biological Chemistry · doi:10.1074/jbc.273.35.22298 · Cited by 374
Cited by
Phosphoinositides: Tiny Lipids With Giant Impact on Cell Regulation
Balla, T. (2013) · Physiological Reviews · doi:10.1152/physrev.00028.2012 · Cited by 1,638
Kusumi, A., Nakada, C., Ritchie, K., Murase, K., Suzuki, K., Murakoshi, H., Kasai, R. S., Kondo, J., & Fujiwara, T. (2005) · Annual Review of Biophysics and Biomolecular Structure · doi:10.1146/annurev.biophys.34.040204.144637 · Cited by 1,122
Lipid rafts: contentious only from simplistic standpoints
Hancock, J. F. (2006) · Nature Reviews Molecular Cell Biology · doi:10.1038/nrm1925 · Cited by 788
Ultrastructural identification of uncoated caveolin-independent early endocytic vehicles
Kirkham, M., Fujita, A., Chadda, R., Nixon, S. J., Kurzchalia, T. V., Sharma, D. K., Pagano, R. E., Hancock, J. F., Mayor, S., & Parton, R. G. (2005) · The Journal of Cell Biology · doi:10.1083/jcb.200407078 · Cited by 439
Clathrin-independent endocytosis: New insights into caveolae and non-caveolar lipid raft carriers
Kirkham, M., & Parton, R. G. (2005) · Biochimica et Biophysica Acta (BBA) - Molecular Cell Research · doi:10.1016/j.bbamcr.2005.06.002 · Cited by 438
Metadata
- Authors
- Kwik, J., Boyle, S., Fooksman, D., Margolis, L., Sheetz, M. P., & Edidin, M.
- Venue
- Proceedings of the National Academy of Sciences
- Published
- 2003-11-11
- Volume
- 100
- Issue
- 24
- Pages
- 13964-13969
- ISSN
- 0027-8424 (ISSN-L)
- 1091-6490
- OpenAlex
- W2160085864
- Cited by
- 485
- References
- 3
- FWCI
- 10.29
- Type
- journal article
- Language
- en
- Open access
- green
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- Kwik, J., Boyle, S., Fooksman, D., Margolis, L., Sheetz, M. P., & Edidin, M. (2003). Membrane cholesterol, lateral mobility, and the phosphatidylinositol 4,5-bisphosphate-dependent organization of cell actin. Proceedings of the National Academy of Sciences. https://doi.org/10.1073/pnas.2336102100
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