The DOI matches its Crossref record; 63 of the 63 references it cites were found in a registry or an index.
Paradigm Shift of the Plasma Membrane Concept from the Two-Dimensional Continuum Fluid to the Partitioned Fluid: High-Speed Single-Molecule Tracking of Membrane Molecules
Abstract
▪ Abstract Recent advancements in single-molecule tracking methods with nanometer-level precision now allow researchers to observe the movement, recruitment, and activation of single molecules in the plasma membrane in living cells. In particular, on the basis of the observations by high-speed single-particle tracking at a frame rate of 40,000 frames s−1, the partitioning of the fluid plasma membrane into submicron compartments throughout the cell membrane and the hop diffusion of virtually all the molecules have been proposed. This could explain why the diffusion coefficients in the plasma membrane are considerably smaller than those in artificial membranes, and why the diffusion coefficient is reduced upon molecular complex formation (oligomerization-induced trapping). In this review, we first describe the high-speed single-molecule tracking methods, and then we critically review a new model of a partitioned fluid plasma membrane and the involvement of the actin-based membrane-skeleton “fences” and anchored-transmembrane protein “pickets” in the formation of compartment boundaries.
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Cites
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Self-citationPhospholipids undergo hop diffusion in compartmentalized cell membrane
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Cited by
Membrane lipids: where they are and how they behave
van Meer, G., Voelker, D. R., & Feigenson, G. W. (2008) · Nature Reviews Molecular Cell Biology · doi:10.1038/nrm2330 · Cited by 7,157
The mystery of membrane organization: composition, regulation and roles of lipid rafts
Sezgin, E., Levental, I., Mayor, S., & Eggeling, C. (2017) · Nature Reviews Molecular Cell Biology · doi:10.1038/nrm.2017.16 · Cited by 2,124
Universal physical responses to stretch in the living cell
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Dynamic multiple-target tracing to probe spatiotemporal cartography of cell membranes
Sergé, A., Bertaux, N., Rigneault, H., & Marguet, D. (2008) · Nature Methods · doi:10.1038/nmeth.1233 · Cited by 632
The interaction between Stargazin and PSD-95 regulates AMPA receptor surface trafficking
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Metadata
- Authors
- Kusumi, A., Nakada, C., Ritchie, K., Murase, K., Suzuki, K., Murakoshi, H., Kasai, R. S., Kondo, J., & Fujiwara, T.
- Venue
- Annual Review of Biophysics and Biomolecular Structure
- Publisher
- Annual Reviews
- Published
- 2005-06-01
- Volume
- 34
- Issue
- 1
- Pages
- 351-378
- ISSN
- 1056-8700 (ISSN-L)
- 1545-4266
- OpenAlex
- W2164565944
- Cited by
- 1,122
- References
- 63
- FWCI
- 22.24
- Type
- journal article
- Language
- en
- Open access
- closed
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- The paper
- Kusumi, A., Nakada, C., Ritchie, K., Murase, K., Suzuki, K., Murakoshi, H., Kasai, R. S., Kondo, J., & Fujiwara, T. (2005). Paradigm Shift of the Plasma Membrane Concept from the Two-Dimensional Continuum Fluid to the Partitioned Fluid: High-Speed Single-Molecule Tracking of Membrane Molecules. Annual Review of Biophysics and Biomolecular Structure. https://doi.org/10.1146/annurev.biophys.34.040204.144637
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