The DOI matches its Crossref record; 5 of the 5 references it cites were found in a registry or an index.
Increased atherosclerosis in hyperlipidemic mice deficient in α-tocopherol transfer protein and vitamin E
Open accessAbstract
Although lipid peroxidation in the subendothelial space has been hypothesized to play a central role in atherogenesis, the role of vitamin E in preventing lipid peroxidation and lesion development remains uncertain. Here we show that in atherosclerosis-susceptible apolipoprotein E knockout mice, vitamin E deficiency caused by disruption of the α-tocopherol transfer protein gene ( Ttpa ) increased the severity of atherosclerotic lesions in the proximal aorta. The increase was associated with increased levels of isoprostanes, a marker of lipid peroxidation, in aortic tissue. These results show that vitamin E deficiency promotes atherosclerosis in a susceptible setting and support the hypothesis that lipid peroxidation contributes to lesion development. Ttpa −/− mice are a genetic model of vitamin E deficiency and should be valuable for studying other diseases in which oxidative stress is thought to play a role.
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Spontaneous Hypercholesterolemia and Arterial Lesions in Mice Lacking Apolipoprotein E
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Vitamin E Supplementation and Cardiovascular Events in High-Risk Patients
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ApoE-deficient mice develop lesions of all phases of atherosclerosis throughout the arterial tree.
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Cited by
Free Radicals in the Physiological Control of Cell Function
Dröge, W. (2002) · Physiological Reviews · doi:10.1152/physrev.00018.2001 · Cited by 9,855
Vitamin effects on the immune system: Vitamins A and D take centre stage
Mora, J. R., Iwata, M., & von Andrian, U. H. (2008) · Nature Reviews Immunology · doi:10.1038/nri2378 · Cited by 1,559
The European perspective on vitamin E: current knowledge and future research
Brigelius-Flohé, R., Kelly, F. J., Salonen, J. T., Neuzil, J., Zingg, J.-M., & Azzi, A. (2002) · The American Journal of Clinical Nutrition · doi:10.1093/ajcn/76.4.703 · Cited by 585
Absorption, transport, and tissue delivery of vitamin E
Rigotti, A. (2007) · Molecular Aspects of Medicine · doi:10.1016/j.mam.2007.01.002 · Cited by 290
Yokota, T., Igarashi, K., Uchihara, T., Jishage, K.-I., Tomita, H., Inaba, A., Li, Y., Arita, M., Suzuki, H., Mizusawa, H., et al. (2001) · Proceedings of the National Academy of Sciences · doi:10.1073/pnas.261456098 · Cited by 261
Metadata
- Authors
- Terasawa, Y., Ladha, Z., Leonard, S. W., Morrow, J. D., Newland, D., Sanan, D., Packer, L., Traber, M. G., & Farese, R. V.
- Venue
- Proceedings of the National Academy of Sciences
- Published
- 2000-11-28
- Volume
- 97
- Issue
- 25
- Pages
- 13830-13834
- ISSN
- 0027-8424 (ISSN-L)
- 1091-6490
- OpenAlex
- W2052608182
- Cited by
- 231
- References
- 5
- FWCI
- 10.01
- Type
- journal article
- Language
- en
- Open access
- green
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- Terasawa, Y., Ladha, Z., Leonard, S. W., Morrow, J. D., Newland, D., Sanan, D., Packer, L., Traber, M. G., & Farese, R. V. (2000). Increased atherosclerosis in hyperlipidemic mice deficient in α-tocopherol transfer protein and vitamin E. Proceedings of the National Academy of Sciences. https://doi.org/10.1073/pnas.240462697
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Contains information from the Semantic Scholar Academic Graph Datasets, made available under the ODC Attribution License (ODC-BY 1.0).
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