The DOI matches its Crossref record; 28 of the 28 references it cites were found in a registry or an index.
Cryoelectron microscopy of λ phage DNA condensates in vitreous ice: The fine structure of DNA toroids
Open accessAbstract
DNA toroids produced by the condensation of λ phage DNA with hexammine cobalt (III) have been investigated by cryoelectron microscopy. Image resolution obtained by this technique has allowed unprecedented views of DNA packing within toroidal condensates. Toroids oriented coplanar with the microscope image plane exhibit circular fringes with a repeat spacing of 2.4 nm. For some toroids these fringes are observed around almost the entire circumference of the toroid. However, for most toroids well-defined fringes are limited to less than one-third of the total toroid circumference. Some toroids oriented perpendicular to the image plane reveal DNA polymers organized in a hexagonal close-packed lattice; however, for other toroids alternative packing arrangements are observed. To aid interpretation of electron micrographs, three-dimensional model toroids were generated with perfect hexagonal DNA packing throughout, as well as more physically realistic models that contain crossover points between DNA loops. Simulated transmission electron microscopy images of these model toroids in different orientations faithfully reproduce most features observed in cryoelectron micrographs of actual toroids.
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Citations
Cites
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Solution Structure of the E. coli 70S Ribosome at 11.5 Å Resolution
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Cited by
Structure and interactions of biological helices
Kornyshev, A. A., Lee, D. J., Leikin, S., & Wynveen, A. (2007) · Reviews of Modern Physics · doi:10.1103/revmodphys.79.943 · Cited by 320
Molecular architecture of the prolate head of bacteriophage T4
Fokine, A., Chipman, P. R., Leiman, P. G., Mesyanzhinov, V. V., Rao, V. B., & Rossmann, M. G. (2004) · Proceedings of the National Academy of Sciences · doi:10.1073/pnas.0400444101 · Cited by 289
Cui, H., Hodgdon, T. K., Kaler, E. W., Abezgauz, L., Danino, D., Lubovsky, M., Talmon, Y., & Pochan, D. J. (2007) · Soft Matter · doi:10.1039/b704194b · Cited by 208
Liu, L., Pincus, P. A., & Hyeon, C. (2017) · Macromolecules · doi:10.1021/acs.macromol.6b02685 · Cited by 40
Dendritic and Nanowire Assemblies of Condensed DNA Polymer Brushes
Bracha, D., & Bar-Ziv, R. H. (2014) · Journal of the American Chemical Society · doi:10.1021/ja410960w · Cited by 32
Metadata
- Authors
- Hud, N. V., & Downing, K. H.
- Venue
- Proceedings of the National Academy of Sciences
- Published
- 2001-12-04
- Volume
- 98
- Issue
- 26
- Pages
- 14925-14930
- ISSN
- 0027-8424 (ISSN-L)
- 1091-6490
- OpenAlex
- W2041811684
- Cited by
- 270
- References
- 28
- FWCI
- 4.23
- Type
- journal article
- Language
- en
- Open access
- green
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- Hud, N. V., & Downing, K. H. (2001). Cryoelectron microscopy of λ phage DNA condensates in vitreous ice: The fine structure of DNA toroids. Proceedings of the National Academy of Sciences. https://doi.org/10.1073/pnas.261560398
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