Cited by 208Advanced Electron Microscopy Techniques and ApplicationsSurfactants and Colloidal SystemsAdvanced Polymer Synthesis and Characterization

Elucidating the assembled structure of amphiphiles in solution via cryogenic transmission electron microscopy

Cui, Honggang, Hodgdon, Travis K., Kaler, Eric W., Abezgauz, Ludmila, Danino, Dganit, Lubovsky, Maya, Talmon, Yeshayahu, Pochan, Darrin J.·2007·Soft Matter

Abstract

For the past twenty years, significant progress has been made in both developing cryogenic transmission electron microscopy (cryo-TEM) technology and understanding assembled behavior of amphiphilic molecules. Cryo-TEM can provide high-resolution images of complex fluids in a near state. Samples embedded in a thin layer of vitrified solvent do not exhibit artifacts that would normally occur when using chemical fixation or staining-and-drying techniques. Cryo-TEM has been useful in imaging biological molecules in aqueous solutions. Cryo-TEM has become a powerful tool in the study of -assembled structures of amphiphiles in solution as a complementary tool to small-angle X-ray and neutron scattering, light scattering, rheology measurements, and nuclear magnetic resonance. The application of cryo-TEM in the study of assembled behavior of amphiphilic block copolymers, hydrogels, and other complex soft systems continues to emerge. In this context, the usage of cryo-TEM in the field of amphiphilic complex fluids and self-assembled nano-materials is briefly reviewed, and its unique role in exploring the nature of assembled structure in liquid suspension is highlighted.

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Crossref · 10.1039/b704194b

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Authors
Cui, H., Hodgdon, T. K., Kaler, E. W., Abezgauz, L., Danino, D., Lubovsky, M., Talmon, Y., & Pochan, D. J.
Affiliations
  • Delaware Biotechnology Institute (US)
  • University of Delaware (US)
  • Technion – Israel Institute of Technology (IL)
Corresponding author
Pochan, Darrin J.
Venue
Soft Matter
Published
2007
Volume
3
Issue
8
Pages
945
ISSN
  • 1744-683X (ISSN-L)
  • 1744-6848
OpenAlex
W2118147816
Cited by
208
References
104
Citations by year
2026: 4 · 2025: 5 · 2024: 6 · 2023: 8 · 2022: 3 · 2021: 13 · 2020: 10 · 2019: 7 · 2018: 9 · 2017: 8 · 2016: 10 · 2015: 12 · 2014: 15 · 2013: 9 · 2012: 20
FWCI
14.02
Type
journal article
Language
en
Open access
closed
Locations
  • Soft Matter (publishedVersion)
  • PubMed (publishedVersion)
Topics
  • Life Sciences › Biochemistry, Genetics and Molecular Biology › Structural Biology › Advanced Electron Microscopy Techniques and Applications
  • Physical Sciences › Chemistry › Organic Chemistry › Surfactants and Colloidal Systems
  • Physical Sciences › Chemistry › Organic Chemistry › Advanced Polymer Synthesis and Characterization
Keywords
amphiphilic molecules, self-assembly, cryo-TEM, block copolymers, hydrogels, complex fluids, self-assembled nanomaterials, liquid suspensions

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