The DOI matches its Crossref record; 1 of the 1 references it cites were found in a registry or an index.
Prevalence of somatic alterations in the colorectal cancer cell genome
Open accessAbstract
Although a small fraction of human cancers have increased rates of somatic mutation because of known deficiencies in DNA repair, little is known about the prevalence of somatic alterations in the vast majority of human cancers. To systematically assess nonsynonymous somatic alterations in colorectal neoplasia, we used DNA sequencing to analyze ≈3.2 Mb of coding tumor DNA comprising 1,811 exons from 470 genes. In total, we identified only three distinct somatic mutations, comprising two missense changes and one 14-bp deletion, each in a different gene. The accumulation of approximately one nonsynonymous somatic change per Mb of tumor DNA is consistent with a rate of mutation in tumor cells that is similar to that of normal cells. These data suggest that most sporadic colorectal cancers do not display a mutator phenotype at the nucleotide level. They also have significant implications for the interpretation of somatic mutations in candidate tumor-suppressor genes.
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Genetic instabilities in human cancers
Lengauer, C., Kinzler, K. W., & Vogelstein, B. (1998) · Nature · doi:10.1038/25292 · Cited by 4,168
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Self-citationRAF/RAS oncogenes and mismatch-repair status
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Mutational Analysis of the Tyrosine Phosphatome in Colorectal Cancers
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Self-citationA spatial model predicts that dispersal and cell turnover limit intratumour heterogeneity
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Metadata
- Authors
- Wang, T.-L., Rago, C., Silliman, N., Ptak, J., Markowitz, S., Willson, J. K. V., Parmigiani, G., Kinzler, K. W., Vogelstein, B., & Velculescu, V. E.
- Venue
- Proceedings of the National Academy of Sciences
- Published
- 2002-02-26
- Volume
- 99
- Issue
- 5
- Pages
- 3076-3080
- ISSN
- 0027-8424 (ISSN-L)
- 1091-6490
- OpenAlex
- W1970847438
- Cited by
- 177
- References
- 1
- FWCI
- 11.32
- Type
- journal article
- Language
- en
- Open access
- green
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- Wang, T.-L., Rago, C., Silliman, N., Ptak, J., Markowitz, S., Willson, J. K. V., Parmigiani, G., Kinzler, K. W., Vogelstein, B., & Velculescu, V. E. (2002). Prevalence of somatic alterations in the colorectal cancer cell genome. Proceedings of the National Academy of Sciences. https://doi.org/10.1073/pnas.261714699
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