The DOI matches its Crossref record; 24 of the 24 references it cites were found in a registry or an index.
Mutational Analysis of the Tyrosine Phosphatome in Colorectal Cancers
Abstract
Tyrosine phosphorylation, regulated by protein tyrosine phosphatases (PTPs) and kinases (PTKs), is important in signaling pathways underlying tumorigenesis. A mutational analysis of the tyrosine phosphatase gene superfamily in human cancers identified 83 somatic mutations in six PTPs ( PTPRF, PTPRG, PTPRT, PTPN3, PTPN13, PTPN14 ), affecting 26% of colorectal cancers and a smaller fraction of lung, breast, and gastric cancers. Fifteen mutations were nonsense, frameshift, or splice-site alterations predicted to result in truncated proteins lacking phosphatase activity. Five missense mutations in the most commonly altered PTP ( PTPRT ) were biochemically examined and found to reduce phosphatase activity. Expression of wild-type but not a mutant PTPRT in human cancer cells inhibited cell growth. These observations suggest that the mutated tyrosine phosphatases are tumor suppressor genes, regulating cellular pathways that may be amenable to therapeutic intervention.
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Cited by
Balancing cell adhesion and Wnt signaling, the key role of β-catenin
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Ptpn11/Shp2 Acts as a Tumor Suppressor in Hepatocellular Carcinogenesis
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Metadata
- Authors
- Wang, Z., Shen, D., Parsons, D. W., Bardelli, A., Sager, J., Szabo, S., Ptak, J., Silliman, N., Peters, B. A., van der Heijden, M. S., Parmigiani, G., Yan, H., Wang, T.-L., Riggins, G., Powell, S. M., Willson, J. K. V., Markowitz, S., Kinzler, K. W., Vogelstein, B., & Velculescu, V. E.
- Venue
- Science
- Published
- 2004-05-21
- Volume
- 304
- Issue
- 5674
- Pages
- 1164-1166
- ISSN
- 0036-8075 (ISSN-L)
- 1095-9203
- OpenAlex
- W2099224719
- Cited by
- 522
- References
- 24
- FWCI
- 13.78
- Type
- journal article
- Language
- en
- Open access
- closed
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- Wang, Z., Shen, D., Parsons, D. W., Bardelli, A., Sager, J., Szabo, S., Ptak, J., Silliman, N., Peters, B. A., van der Heijden, M. S., Parmigiani, G., Yan, H., Wang, T.-L., Riggins, G., Powell, S. M., Willson, J. K. V., Markowitz, S., Kinzler, K. W., Vogelstein, B., & Velculescu, V. E. (2004). Mutational Analysis of the Tyrosine Phosphatome in Colorectal Cancers. Science. https://doi.org/10.1126/science.1096096
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Contains information from the Semantic Scholar Academic Graph Datasets, made available under the ODC Attribution License (ODC-BY 1.0).
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