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Photoresponsive polymer–enzyme switches
Open accessAbstract
The ability to photoregulate enzyme activities could provide important new opportunities for development of diagnostic assays, sequential bioprocessing, and lab assays in both traditional and microfluidic formats. We show here that the photoinduced changes in the size and hydration of a “smart” polymer chain coil can be used to regulate substrate access and enzyme activity when conjugated to the enzyme at a specific point just outside the active site. The photoresponsive polymers thus serve jointly as antennae and actuators that reversibly respond to distinct optical signals to switch the polymer–enzyme conjugates on and off, and work when the conjugate is free in solution or when immobilized on magnetic beads.
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Cited by
Thermo- and pH-responsive polymers in drug delivery☆
SCHMALJOHANN, D. (2006) · Advanced Drug Delivery Reviews · doi:10.1016/j.addr.2006.09.020 · Cited by 3,023
Biomaterials: Where We Have Been and Where We Are Going
Ratner, B. D., & Bryant, S. J. (2004) · Annual Review of Biomedical Engineering · doi:10.1146/annurev.bioeng.6.040803.140027 · Cited by 1,507
In Situ Preparation of Protein−“Smart” Polymer Conjugates with Retention of Bioactivity
Heredia, K. L., Bontempo, D., Ly, T., Byers, J. T., Halstenberg, S., & Maynard, H. D. (2005) · Journal of the American Chemical Society · doi:10.1021/ja054482w · Cited by 451
Photophysics Modulation in Photoswitchable Metal–Organic Frameworks
Rice, A. M., Martin, C. R., Galitskiy, V. A., Berseneva, A. A., Leith, G. A., & Shustova, N. B. (2020) · Chemical Reviews · doi:10.1021/acs.chemrev.9b00350 · Cited by 432
Metadata
- Authors
- Shimoboji, T., Larenas, E., Fowler, T., Kulkarni, S., Hoffman, A. S., & Stayton, P. S.
- Venue
- Proceedings of the National Academy of Sciences
- Published
- 2002-12-16
- Volume
- 99
- Issue
- 26
- Pages
- 16592-16596
- ISSN
- 0027-8424 (ISSN-L)
- 1091-6490
- OpenAlex
- W2079202953
- Cited by
- 322
- References
- 0
- FWCI
- 4.68
- Type
- journal article
- Language
- en
- Open access
- green
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- Shimoboji, T., Larenas, E., Fowler, T., Kulkarni, S., Hoffman, A. S., & Stayton, P. S. (2002). Photoresponsive polymer–enzyme switches. Proceedings of the National Academy of Sciences. https://doi.org/10.1073/pnas.262427799
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Contains information from the Semantic Scholar Academic Graph Datasets, made available under the ODC Attribution License (ODC-BY 1.0).
Semantic Scholar’s data is described in: Kinney, R., et al. (2023). The Semantic Scholar Open Data Platform. arXiv:2301.10140.
