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α-KETO ACID DEHYDROGENASE COMPLEXES, X. REGULATION OF THE ACTIVITY OF THE PYRUVATE DEHYDROGENASE COMPLEX FROM BEEF KIDNEY MITOCHONDRIA BY PHOSPHORYLATION AND DEPHOSPHORYLATION
Open accessAbstract
This paper reports the discovery that the activity of the multienzyme pyruvate dehydrogenase complex from beef kidney mitochondria is regulated by a phosphorylation-dephosphorylation reaction sequence. The site of this regulation is the pyruvate dehydrogenase component of the complex. Phosphorylation and concomitant inactivation of pyruvate dehydrogenase are catalyzed by an ATP-specific kinase (i.e., a pyruvate dehydrogenase kinase), and dephosphorylation and concomitant reactivation are catalyzed by a phosphatase (i.e., a pyruvate dehydrogenase phosphatase). The kinase and the phosphatase appear to be regulatory subunits of the pyruvate dehydrogenase complex.
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Cited by
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Mitochondria: More Than Just a Powerhouse
McBride, H. M., Neuspiel, M., & Wasiak, S. (2006) · Current Biology · doi:10.1016/j.cub.2006.06.054 · Cited by 1,985
An atlas of substrate specificities for the human serine/threonine kinome
Johnson, J. L., Yaron, T. M., Huntsman, E. M., Kerelsky, A., Song, J., Regev, A., Lin, T.-Y., Liberatore, K., Cizin, D. M., Cohen, B. M., et al. (2023) · Nature · doi:10.1038/s41586-022-05575-3 · Cited by 728
Evidence for existence of tissue-specific regulation of the mammalian pyruvate dehydrogenase complex
BOWKER-KINLEY, M. M., DAVIS, I. W., WU, P., HARRIS, A. R., & POPOV, M. K. (1998) · Biochemical Journal · doi:10.1042/bj3290191 · Cited by 565
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Metadata
- Authors
- Linn, T. C., Pettit, F. H., & Reed, L. J.
- Venue
- Proceedings of the National Academy of Sciences
- Published
- 1969-01
- Volume
- 62
- Issue
- 1
- Pages
- 234-241
- ISSN
- 0027-8424 (ISSN-L)
- 1091-6490
- OpenAlex
- W2061202598
- Cited by
- 671
- References
- 0
- FWCI
- 10.07
- Type
- journal article
- Language
- en
- Open access
- green
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- CoChat. (2026). Citation check: α-KETO ACID DEHYDROGENASE COMPLEXES, X. REGULATION OF THE ACTIVITY OF THE PYRUVATE DEHYDROGENASE COMPLEX FROM BEEF KIDNEY MITOCHONDRIA BY PHOSPHORYLATION AND DEPHOSPHORYLATION. https://app.cochat.ai/papers/10.1073/pnas.62.1.234
- The paper
- Linn, T. C., Pettit, F. H., & Reed, L. J. (1969). α-KETO ACID DEHYDROGENASE COMPLEXES, X. REGULATION OF THE ACTIVITY OF THE PYRUVATE DEHYDROGENASE COMPLEX FROM BEEF KIDNEY MITOCHONDRIA BY PHOSPHORYLATION AND DEPHOSPHORYLATION. Proceedings of the National Academy of Sciences. https://doi.org/10.1073/pnas.62.1.234
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Bibliographic data: Semantic Scholar, OpenAlex, Crossref.
Contains information from the Semantic Scholar Academic Graph Datasets, made available under the ODC Attribution License (ODC-BY 1.0).
Semantic Scholar’s data is described in: Kinney, R., et al. (2023). The Semantic Scholar Open Data Platform. arXiv:2301.10140.
