The DOI matches its Crossref record.
INHIBITION OF TUMOR GROWTH BY POLYINOSINIC-POLYCYTIDYLIC ACID
Open accessAbstract
The synthetic double-stranded RNA, polyinosinic-cytidylic acid, inhibits the growth of some tumors in mice. Two days after implantation of a reticulum cell sarcoma, a lymphatic lymphoma, a fibrosarcoma, two leukemias, and a human adenovirus 12-induced tumor, treatment of groups of mice resulted in decreased growth rates of the tumors and increased survival times of the animals. In the two tumors tested (the reticulum cell sarcoma and the adenovirus 12-induced tumor) initiation of treatment after the tumor was grown to moderate size caused a regression of the tumor. In the case of the reticulum cell sarcoma, the tumor had not reappeared in some of the animals two months after cessation of treatment.
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Cited by
Endotoxin and Double Stranded RNA render Macrophages Cytotoxic
ALEXANDER, P., & EVANS, R. (1971) · Nature New Biology · doi:10.1038/newbio232076a0 · Cited by 438
Paone, A., Starace, D., Galli, R., Padula, F., De Cesaris, P., Filippini, A., Ziparo, E., & Riccioli, A. (2008) · Carcinogenesis · doi:10.1093/carcin/bgn149 · Cited by 160
Matsumoto, M., Tatematsu, M., Nishikawa, F., Azuma, M., Ishii, N., Morii-Sakai, A., Shime, H., & Seya, T. (2015) · Nature Communications · doi:10.1038/ncomms7280 · Cited by 130
Metadata
- Authors
- Levy, H. B., Law, L. W., & Rabson, A. S.
- Venue
- Proceedings of the National Academy of Sciences
- Published
- 1969-02
- Volume
- 62
- Issue
- 2
- Pages
- 357-361
- ISSN
- 0027-8424 (ISSN-L)
- 1091-6490
- OpenAlex
- W2049034780
- Cited by
- 181
- References
- 0
- FWCI
- 20.97
- Type
- journal article
- Language
- en
- Open access
- green
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- CoChat. (2026). Citation check: INHIBITION OF TUMOR GROWTH BY POLYINOSINIC-POLYCYTIDYLIC ACID. https://app.cochat.ai/papers/10.1073/pnas.62.2.357
- The paper
- Levy, H. B., Law, L. W., & Rabson, A. S. (1969). INHIBITION OF TUMOR GROWTH BY POLYINOSINIC-POLYCYTIDYLIC ACID. Proceedings of the National Academy of Sciences. https://doi.org/10.1073/pnas.62.2.357
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Contains information from the Semantic Scholar Academic Graph Datasets, made available under the ODC Attribution License (ODC-BY 1.0).
Semantic Scholar’s data is described in: Kinney, R., et al. (2023). The Semantic Scholar Open Data Platform. arXiv:2301.10140.
