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A FLUORESCENCE PROBE OF ENERGY-DEPENDENT STRUCTURE CHANGES IN FRAGMENTED MEMBRANES
Open accessAbstract
The reaction of the fluorochrome, 8-anilino-1-naphthalene-sulfonic acid (ANS), with fragmented membranes from beef heart mitochondria has been studied. ANS fluorescence is found to be enhanced 25-fold on binding to the membrane fragments in the absence of energy conservation, and this enhancement is increased to 35-fold in the membrane energized by substrate plux oxygen. The fluorescence of bound ANS depends upon the energy state of the membrane fragments, as indicated by the effects of ATP, substrates of the respiratory chain, oligomycin, and uncouplers. It is concluded that the changes of ANS fluorescence indicate structural changes of the mitochondrial membrane associated with energy conservation. The time course of energization is readily followed by ANS, and has a half-time of two seconds at 26°.
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Citations
Cited by
Monitoring of relative mitochondrial membrane potential in living cells by fluorescence microscopy.
Johnson, L. V., Walsh, M. L., Bockus, B. J., & Chen, L. B. (1981) · The Journal of cell biology · doi:10.1083/jcb.88.3.526 · Cited by 913
Bereiter‐Hahn, J., & Vöth, M. (1994) · Microscopy Research and Technique · doi:10.1002/jemt.1070270303 · Cited by 900
Conservation and transformation of energy by bacterial membranes
Harold, F. M. (1972) · Bacteriological Reviews · doi:10.1128/br.36.2.172-230.1972 · Cited by 666
Optical measurement of membrane potential
Cohen, L. B., & Salzberg, B. M. (1978) · Reviews of Physiology, Biochemistry and Pharmacology · doi:10.1007/3-540-08907-1_2 · Cited by 522
Metadata
- Authors
- Azzi, A., Chance, B., Radda, G. K., & Lee, C. P.
- Venue
- Proceedings of the National Academy of Sciences
- Published
- 1969-02
- Volume
- 62
- Issue
- 2
- Pages
- 612-619
- ISSN
- 0027-8424 (ISSN-L)
- 1091-6490
- OpenAlex
- W2020523515
- Cited by
- 191
- References
- 0
- FWCI
- 16.95
- Type
- journal article
- Language
- en
- Open access
- green
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- CoChat. (2026). Citation check: A FLUORESCENCE PROBE OF ENERGY-DEPENDENT STRUCTURE CHANGES IN FRAGMENTED MEMBRANES. https://app.cochat.ai/papers/10.1073/pnas.62.2.612
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- Azzi, A., Chance, B., Radda, G. K., & Lee, C. P. (1969). A FLUORESCENCE PROBE OF ENERGY-DEPENDENT STRUCTURE CHANGES IN FRAGMENTED MEMBRANES. Proceedings of the National Academy of Sciences. https://doi.org/10.1073/pnas.62.2.612
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Semantic Scholar’s data is described in: Kinney, R., et al. (2023). The Semantic Scholar Open Data Platform. arXiv:2301.10140.
