The DOI matches its Crossref record.
DIABETES MELLITUS AND AGING: DIMINISHED PLATING EFFICIENCY OF CULTURED HUMAN FIBROBLASTS
Open accessAbstract
This work concerns the effect of age and the diabetic gene(s) on the growth capacity of skin fibroblasts in culture. Cells from normal subjects and the progeny of conjugal diabetics have similar lifespans after multiple passages in mass culture. The combined lifespans in vitro are inversely proportional to the age of the donor. When individual cells are plated, more of those from normal subjects are able to form colonies. The difference in plating efficiency is apparent when first tested after 20 generations of growth, persists at 30 and 40 generations, but disappears after 50 generations. This cell culture system should be useful in studying the inheritance of the diabetic gene(s), the pathogenesis of the diabetic state, and the relationship between aging and diabetes, both of which decrease plating efficiency.
Overview
The claims and statistics of this paper haven’t been checked yet.
Run the check — free, no account needed. It reads the open-access text and checks the sources it cites.
Integrity signals
Registry
Cites
Statistics
Verification
Claims the paper makes
The claims and statistics of this paper haven’t been checked yet.
Run the check — free, no account needed. It reads the open-access text and checks the sources it cites.
Self-check
Percentages, sums and reported differences re-computed from the paper’s own numbers.
The self-check needs the paper’s full text.
Citations
Cited by
Three clonal types of keratinocyte with different capacities for multiplication.
Barrandon, Y., & Green, H. (1987) · Proceedings of the National Academy of Sciences · doi:10.1073/pnas.84.8.2302 · Cited by 1,294
Differentiation of the mammary gland and susceptibility to carcinogenesis
Russo, J., Tay, L. K., & Russo, I. H. (1982) · Breast Cancer Research and Treatment · doi:10.1007/bf01805718 · Cited by 629
Acceleration of β Cell Aging Determines Diabetes and Senolysis Improves Disease Outcomes
Aguayo-Mazzucato, C., Andle, J., Lee, T. B., Midha, A., Talemal, L., Chipashvili, V., Hollister-Lock, J., van Deursen, J., Weir, G., & Bonner-Weir, S. (2019) · Cell Metabolism · doi:10.1016/j.cmet.2019.05.006 · Cited by 469
Hierarchical deterioration of body systems in Werner's syndrome: Implications for normal ageing
Goto, M. (1997) · Mechanisms of Ageing and Development · doi:10.1016/s0047-6374(97)00111-5 · Cited by 240
Goldstein, S., Moerman, E. J., Fujii, S., & Sobel, B. E. (1994) · Journal of Cellular Physiology · doi:10.1002/jcp.1041610321 · Cited by 59
Self-citation
Metadata
- Authors
- Goldstein, S., Littlefield, J. W., & Soeldner, J. S.
- Venue
- Proceedings of the National Academy of Sciences
- Published
- 1969-09
- Volume
- 64
- Issue
- 1
- Pages
- 155-160
- ISSN
- 0027-8424 (ISSN-L)
- 1091-6490
- OpenAlex
- W2080612757
- Cited by
- 185
- References
- 0
- FWCI
- 6.22
- Type
- journal article
- Language
- en
- Open access
- green
About these checks
Registry, retraction, Cites and statistics results are computed, not judged, with one exception: a printed reference that no index lists is read once by a model before it counts as a citation error. Claims are extracted by a model and kept only when their quote appears verbatim in the text; each cited source is then checked, with a model’s help, for whether it says what the claim relies on. Those verdicts can be wrong — read the claim’s quote and the cited source before relying on one.
Statistics and arithmetic are recomputed, not judged.
Confidence bands are shown only for fields calibrated on our annotated test set. None is calibrated yet, so no band is shown.
What counts as a claim ›How we measure confidence ›How we check this ›
Are you an author, or do you see a problem with this page? Request a review
How to cite
Cite CoChat for the checks on this page, and the paper for its own findings.
- This page
- CoChat. (2026). Citation check: DIABETES MELLITUS AND AGING: DIMINISHED PLATING EFFICIENCY OF CULTURED HUMAN FIBROBLASTS. https://app.cochat.ai/papers/10.1073/pnas.64.1.155
- The paper
- Goldstein, S., Littlefield, J. W., & Soeldner, J. S. (1969). DIABETES MELLITUS AND AGING: DIMINISHED PLATING EFFICIENCY OF CULTURED HUMAN FIBROBLASTS. Proceedings of the National Academy of Sciences. https://doi.org/10.1073/pnas.64.1.155
Data sources
Bibliographic data: Semantic Scholar, OpenAlex, Crossref.
Contains information from the Semantic Scholar Academic Graph Datasets, made available under the ODC Attribution License (ODC-BY 1.0).
Semantic Scholar’s data is described in: Kinney, R., et al. (2023). The Semantic Scholar Open Data Platform. arXiv:2301.10140.
