Overexpression of plasminogen activator inhibitor type‐1 in senescent fibroblasts from normal subjects and those with Werner syndrome
Abstract
We previously reported that plasminogen activator inhibitor type‐1 (PAI‐1) mRNA was present at higher steady‐state levels in prematurely senescent fibroblasts derived from a subject with Werner syndrome (WS) compared to early passage (EP) fibroblasts from an age‐matched normal subject (Murano et al., 1991, Mol. Cell. Biol. 11:3905–3914). To explore the generality of this phenomenon with respect to chronological age of donor (in vivo aging) and the late‐passage (LP) or senescent phase of the fibroblast replicative lifespan, we assayed PAI‐1 mRNA in cells and PAI‐1 antigen in medium conditioned by 20 normal fibroblast strains at EP and LP and six WS strains during their curtailed replicative lifespans. The lowest accumulations of PAI‐1 were found in medium conditioned by fetal and newborn cells with a shallow but progressive rise seen in postnatal cells from normal donors of increasing chronological age. With few exceptions, normal LP fibroblasts showed increased PAI‐1 accumulations in medium compared to their EP counterparts. Conditioned medium from four of the six WS strains showed PAI‐1 accumulations that were significantly higher than the media of any normal controls at EP and LP. PAI‐1 mRNA levels were generally commensurate with the cumulative amount of PAI‐1 in the medium but the frequent exceptions indicate that translational and post‐translational mechanisms also regulate PAI‐1 output. The augmentation in PAI‐1 output of fibroblasts as a direct function of chronological age and during in vitro senescence suggests that PAI‐1 may play an important role in the reduced capacity for wound healing and the increasing tendency to thrombogenesis and atherogenesis seen during biological aging and in particular in persons with Werner syndrome. © 1994 Wiley‐Liss, Inc.
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Late passage human fibroblasts or fibroblasts from subjects with premature aging syndromes produce secretory proteins including PAI-1, which later became a functional marker of senescence.
“Early studies showed that late passage human fibroblasts or fibroblasts derived from subjects with premature aging syndromes produce secretory proteins, including plasminogen activator inhibitor type-1 (PAI-1), which later became a functional marker of senescence (Murano et al. 1991; Goldstein et al. 1994; Kortlever et al. 2006).”
From Cellular senescence and its effector programs (2014) · cites this paper as Goldstein et al. 1994
Cites
Single-Step Method of RNA Isolation by Acid Guanidinium Thiocyanate–Phenol–Chloroform Extraction
Chomczynski, P., & Sacchi, N. (1987) · Analytical Biochemistry · doi:10.1006/abio.1987.9999 · Cited by 65,240 · see citing works
Single-step method of RNA isolation by acid guanidinium thiocyanate-phenol-chloroform extraction
Chomczyński, P., & Sacchi, N. (1987) · Analytical Biochemistry · doi:10.1016/0003-2697(87)90021-2 · Cited by 47,092 · see citing works
The limited in vitro lifetime of human diploid cell strains
Hayflick, L. (1965) · Experimental Cell Research · doi:10.1016/0014-4827(65)90211-9 · Cited by 5,876 · see citing works
Statistical Methods in Medical Research.
Armitage, P. (1972) · Biometrics · doi:10.2307/2556182 · Cited by 5,383 · see citing works
DeFronzo, R. A., & Ferrannini, E. (1991) · Diabetes Care · doi:10.2337/diacare.14.3.173 · Cited by 4,555 · see citing works
Replicative life-span of cultivated human cells. Effects of donor's age, tissue, and genotype.
Gm, M., Sprague, C. A., & Cj, E. (1970) · PubMed · Cited by 1,003 · see citing works
EPSTKIN, C. J., MARTIN, G. M., SCHULTZ, A. L., & MOTULSKYS, A. G. (1966) · Medicine · doi:10.1097/00005792-196605000-00001 · Cited by 840 · see citing works
Cell-Associated Plasminogen Activation: Regulation and Physiological Functions
Saksela, O., & Rifkin, D. B. (1988) · Annual Review of Cell Biology · doi:10.1146/annurev.cb.04.110188.000521 · Cited by 822 · see citing works
Replicative Senescence: the Human Fibroblast Comes of Age
Goldstein, S. (1990) · Science · doi:10.1126/science.2204114 · Cited by 651 · see citing works
Self-citationJuhan-Vague, I., Alessi, M., & Vague, P. (1991) · Diabetologia · doi:10.1007/bf00403280 · Cited by 566 · see citing works
Declerck, P. J., Alessi, M., Verstreken, M. F. K., Kruithof, E. K. O., Juhan-Vague, I., & Collen, D. (1988) · Blood · doi:10.1182/blood.v71.1.220.220 · Cited by 537 · see citing works
Factors Responsible for Impaired Fibrinolysis in Obese Subjects and NIDDM Patients
McGill, J. B., Schneider, D. J., Arfken, C. L., Lucore, C. L., & Sobel, B. E. (1994) · Diabetes · doi:10.2337/diab.43.1.104 · Cited by 310 · see citing works
Self-citationMurano, S., Thweatt, R., Shmookler Reis, R. J., Jones, R. A., Moerman, E. J., & Goldstein, S. (1991) · Molecular and Cellular Biology · doi:10.1128/mcb.11.8.3905 · Cited by 199 · see citing works
Self-citationGoldstein, S., Moerman, E. J., Soeldner, J. S., Gleason, R. E., & Barnett, D. M. (1978) · Science · doi:10.1126/science.622567 · Cited by 190 · see citing works
Self-citationDIABETES MELLITUS AND AGING: DIMINISHED PLATING EFFICIENCY OF CULTURED HUMAN FIBROBLASTS
Goldstein, S., Littlefield, J. W., & Soeldner, J. S. (1969) · Proceedings of the National Academy of Sciences · doi:10.1073/pnas.64.1.155 · Cited by 185 · see citing works
Self-citationSchneider, D. J., & Be, S. (1991) · Proceedings of the National Academy of Sciences · doi:10.1073/pnas.88.22.9959 · Cited by 161 · see citing works
Nordt, T., Schneider, D. J., & Sobel, B. E. (1994) · Circulation · doi:10.1161/01.cir.89.1.321 · Cited by 159 · see citing works
Self-citationLucore, C. L., & Sobel, B. E. (1988) · Circulation · doi:10.1161/01.cir.77.3.660 · Cited by 138 · see citing works
Self-citationSchneider, D. J., Nordt, T. K., & Sobel, B. E. (1992) · Diabetes · doi:10.2337/diab.41.7.890 · Cited by 124 · see citing works
Self-citationGoldstein, S., Moerman, E. J., Jones, R. A., & Baxter, R. C. (1991) · Proceedings of the National Academy of Sciences · doi:10.1073/pnas.88.21.9680 · Cited by 104 · see citing works
Self-citationVascular Thrombosis in Type II Diabetes Mellitus
Colwell, J. A. (1993) · Diabetes · doi:10.2337/diab.42.1.8 · Cited by 102 · see citing works
Goldstein, S., Moerman, E. J., Soeldner, J. S., Gleason, R. E., & Barnett, D. M. (1979) · Journal of Clinical Investigation · doi:10.1172/jci109311 · Cited by 76 · see citing works
Self-citationHuman Genetic Disorders That Feature Premature Onset and Accelerated Progression of Biological Aging
Goldstein, S. (1978) · Springer eBooks · doi:10.1007/978-1-4684-2445-4_8 · Cited by 64 · see citing works
Self-citationHaslam, R. J., & Goldstein, S. (1974) · Biochemical Journal · doi:10.1042/bj1440253 · Cited by 59 · see citing works
Self-citationCheng, R. Z., Murano, S., Kurz, B. W., & Reis, R. J. S. (1990) · Mutation Research/DNAging · doi:10.1016/0921-8734(90)90008-f · Cited by 57 · see citing works
Goldstein, S., Moerman, E. J., & Baxter, R. C. (1993) · Journal of Cellular Physiology · doi:10.1002/jcp.1041560211 · Cited by 54 · see citing works
Self-citationGrowth factors as probes of cell aging
Cristofalo, V. J., Doggett, D. L., Brooks-Frederich, K. M., & Phillips, P. D. (1989) · Experimental Gerontology · doi:10.1016/0531-5565(89)90044-2 · Cited by 39 · see citing works
Fujii, S., Lucore, C. L., Hopkins, W. E., Billadello, J. J., & Sobel, B. E. (1990) · Thrombosis and Haemostasis · doi:10.1055/s-0038-1647329 · Cited by 36 · see citing works
Self-citationHypothesis: Werner syndrome and biological ageing: A molecular genetic hypothesis
Thweatt, R., & Goldstein, S. (1993) · BioEssays · doi:10.1002/bies.950150609 · Cited by 35 · see citing works
Self-citationAnalytical review: The pathogenesis of diabetes mellitus and its relationship to biological aging
Goldstein, S. (1971) · Human Genetics · doi:10.1007/bf00291463 · Cited by 22 · see citing works
Self-citationKlassen, K. J., Nordt, T. K., Schneider, D. J., & Sobel, B. E. (1993) · Coronary Artery Disease · doi:10.1097/00019501-199308000-00007 · Cited by 16 · see citing works
Self-citation
Flagged first, then by citations
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Sorted by citations
Oncogenic ras provokes premature cell senescence associated with accumulation of p53 and p16INK4a
Serrano, M., Lin, A. W., McCurrach, M. E., Beach, D., & Lowe, S. W. (1997) · Cell · doi:10.1016/s0092-8674(00)81902-9 · Cited by 5,178 · see citing works
The essence of senescence: Figure 1.
Kuilman, T., Michaloglou, C., Mooi, W. J., & Peeper, D. S. (2010) · Genes & Development · doi:10.1101/gad.1971610 · Cited by 2,038 · see citing works
Senescence-messaging secretome: SMS-ing cellular stress
Kuilman, T., & Peeper, D. S. (2009) · Nature Reviews Cancer · doi:10.1038/nrc2560 · Cited by 909 · see citing works
Cellular senescence and its effector programs
Salama, R., Sadaie, M., Hoare, M., & Narita, M. (2014) · Genes & Development · doi:10.1101/gad.235184.113 · Cited by 855 · see citing works
Myc activates telomerasePreprint
Wang, J., Xie, L. Y., Allan, S., Beach, D., & Hannon, G. J. (1998) · Genes & Development · doi:10.1101/gad.12.12.1769 · Cited by 653 · see citing works
PML is induced by oncogenic <i>ras</i> and promotes premature senescence
Ferbeyre, G., de Stanchina, E., Querido, E., Baptiste, N., Prives, C., & Lowe, S. W. (2000) · Genes & Development · doi:10.1101/gad.14.16.2015 · Cited by 536 · see citing works
Inside and out: the activities of senescence in cancer
Pérez-Mancera, P. A., Young, A. R. J., & Narita, M. (2014) · Nature Reviews Cancer · doi:10.1038/nrc3773 · Cited by 462 · see citing works
Ota, H., Tokunaga, E., Chang, K., Hikasa, M., Iijima, K., Eto, M., Kozaki, K., Akishita, M., Ouchi, Y., & Kaneki, M. (2005) · Oncogene · doi:10.1038/sj.onc.1209049 · Cited by 431 · see citing works
Biomarkers of cellular senescence and skin aging
Wang, A. S., & Dreesen, O. (2018) · Frontiers in Genetics · doi:10.3389/fgene.2018.00247 · Cited by 404 · see citing works
BRAFE600 in benign and malignant human tumours
Michaloglou, C., Vredeveld, L. C. W., Mooi, W. J., & Peeper, D. S. (2007) · Oncogene · doi:10.1038/sj.onc.1210704 · Cited by 272 · see citing works
Plasminogen Activator Inhibitor-1 Is a Marker and a Mediator of Senescence
Vaughan, D. E., Rai, R., Khan, S. S., Eren, M., & Ghosh, A. K. (2017) · Arteriosclerosis, Thrombosis, and Vascular Biology · doi:10.1161/atvbaha.117.309451 · Cited by 258 · see citing works
Cataloging altered gene expression in young and senescent cells using enhanced differential display
Linskens, M. H. K., Feng, J., Andrews, W. H., Enlow, B., Saati, S. M., Tonkin, L. A., Funk, W. D., & Villeponteau, B. (1995) · Nucleic Acids Research · doi:10.1093/nar/23.16.3244 · Cited by 223 · see citing works
Betz, B. L., Strobeck, M. W., Reisman, D., Knudsen, E. S., & Weissman, B. E. (2002) · Oncogene · doi:10.1038/sj.onc.1205706 · Cited by 212 · see citing works
Homocysteine accelerates endothelial cell senescence
Xu, D. L., Neville, R. F., & Finkel, T. (2000) · FEBS Letters · doi:10.1016/s0014-5793(00)01278-3 · Cited by 207 · see citing works
Wei, S., Wei, S., & Sedivy, J. M. (1999) · PubMed · Cited by 166 · see citing works
Role of Plasminogen Activator Inhibitor-1 in Senescence and Aging
Eren, M., Boe, A. E., Klyachko, E. A., & Vaughan, D. E. (2014) · Seminars in Thrombosis and Hemostasis · doi:10.1055/s-0034-1387883 · Cited by 99 · see citing works
West, M. D., Shay, J. W., Wright, W. E., & Linskens, M. H. K. (1996) · Experimental Gerontology · doi:10.1016/0531-5565(95)02013-6 · Cited by 94 · see citing works
Cellular Senescence and the Kidney: Potential Therapeutic Targets and Tools
Knoppert, S. N., Valentijn, F. A., Nguyen, T. Q., Goldschmeding, R., & Falke, L. L. (2019) · Frontiers in Pharmacology · doi:10.3389/fphar.2019.00770 · Cited by 88 · see citing works
Zhang, D., Zhang, J., Xu, H., Chen, X., Gao, Y., Jiang, H.-G., Wang, Y., Wu, H., Yang, L., Wang, W., et al. (2024) · Molecular Cancer · doi:10.1186/s12943-024-01985-1 · Cited by 82 · see citing works
Targeting senescent cells to attenuate cardiovascular disease progression
Song, P., Zhao, Q., & Zou, M. (2020) · Ageing Research Reviews · doi:10.1016/j.arr.2020.101072 · Cited by 76 · see citing works
Cellular senescence: a view throughout organismal life
von Kobbe, C. (2018) · Cellular and Molecular Life Sciences · doi:10.1007/s00018-018-2879-8 · Cited by 69 · see citing works
Yun, U. J., Park, S. E., Jo, Y. S., Kim, J., & Shin, D. Y. (2012) · Cancer Letters · doi:10.1016/j.canlet.2012.04.003 · Cited by 69 · see citing works
Molecular markers of senescence in fibroblast-like cultures
Cristofalo, V. J., & Pignolo, R. J. (1996) · Experimental Gerontology · doi:10.1016/0531-5565(95)02018-7 · Cited by 59 · see citing works
Mu, X., & Higgins, P. J. (1995) · Journal of Cellular Physiology · doi:10.1002/jcp.1041650324 · Cited by 56 · see citing works
Senescence: an antiviral defense that is tumor suppressive?
Reddel, R. R. (2009) · Carcinogenesis · doi:10.1093/carcin/bgp274 · Cited by 50 · see citing works
Reflections on Telomeres, Growth, Aging, and Essential Hypertension
Aviv, A., & Aviv, H. (1997) · Hypertension · doi:10.1161/01.hyp.29.5.1067 · Cited by 50 · see citing works
Chung, E. J., McKay-Corkum, G. B., Chung, S. I., White, A. O., Scroggins, B. T., Mitchell, J. B., Mulligan‐Kehoe, M. J., & Citrin, D. E. (2015) · International Journal of Radiation Oncology*Biology*Physics · doi:10.1016/j.ijrobp.2015.11.044 · Cited by 46 · see citing works
Adult Sox2+ stem cell exhaustion in mice results in cellular senescence and premature aging
Vilas, J. M., Carneiro, C., Silva‐Álvarez, S. D., Ferreirós, A., González, P., Gómez, M., Ortega, S., Serrano, M., García‐Caballero, T., González‐Barcia, M., et al. (2018) · Aging Cell · doi:10.1111/acel.12834 · Cited by 40 · see citing works
CXCL5‐CXCR2 signaling is a senescence‐associated secretory phenotype in preimplantation embryos
Kawagoe, Y., Kawashima, I., Sato, Y., Okamoto, N., Matsubara, K., & Kawamura, K. (2020) · Aging Cell · doi:10.1111/acel.13240 · Cited by 37 · see citing works
Cellular aging of mitochondrial DNA-depleted cells
Park, S. Y., Choi, B., Cheon, H., Pak, Y. K., Kulawiec, M., Singh, K. K., & Lee, M. (2004) · Biochemical and Biophysical Research Communications · doi:10.1016/j.bbrc.2004.10.182 · Cited by 39 · see citing works
Characterization Of IGFBP-3, PAI-1 and SPARC mRNA expression in senescent fibroblasts
Wang, S. (1996) · Mechanisms of Ageing and Development · doi:10.1016/s0047-6374(96)01814-3 · Cited by 38 · see citing works
Higgins, P. J., Slack, J. K., Diegelmann, R. F., & Staiano‐Coico, L. (1999) · Experimental Cell Research · doi:10.1006/excr.1999.4466 · Cited by 38 · see citing works
Aumailley, L., Garand, C., Dubois, M. J., Johnson, F. B., Marette, A., & Lebel, M. (2015) · PLoS ONE · doi:10.1371/journal.pone.0140292 · Cited by 29 · see citing works
Lee, I., Yeom, S.-Y., Lee, S.-J., Kang, W. K., & Park, C. (2010) · Cancer Research · doi:10.1158/0008-5472.can-09-3791 · Cited by 29 · see citing works
Toda, T., Satoh, M., Sugimoto, M., Goto, M., Furuichi, Y., & Kimura, N. (1998) · Mechanisms of Ageing and Development · doi:10.1016/s0047-6374(97)00131-0 · Cited by 23 · see citing works
Increased plasminogen activator inhibitor type-1 (PAI-1) in the heart as a function of age
Sobel, B. E., Lee, Y., Pratley, R. E., & Schneider, D. J. (2006) · Life Sciences · doi:10.1016/j.lfs.2006.05.011 · Cited by 18 · see citing works
Self-citationAntifibrinolytic Properties of the Vascular Wall
Christ, G., Hufnagl, P., Kaun, C., Mundigler, G., Laufer, G., Huber, K., Wojta, J., & Binder, B. R. (1997) · Arteriosclerosis Thrombosis and Vascular Biology · doi:10.1161/01.atv.17.4.723 · Cited by 18 · see citing works
Biomarkers of senescence in non-human primate adipose depots relate to aging
Kavanagh, K., Sherrill, C., Ruggiero, A. D., Block, M. R., Vemuri, R., Davis, M., & Olivier, A. (2020) · GeroScience · doi:10.1007/s11357-020-00230-z · Cited by 17 · see citing works
Mitogenic factors accelerate later-age diseases: insulin as a paradigm
Lev-Ran, A. (1998) · Mechanisms of Ageing and Development · doi:10.1016/s0047-6374(98)00027-x · Cited by 17 · see citing works
Marcotte, R., Qian, J., Chen, J., & Wang, E. (2003) · Journal of Cellular Biochemistry · doi:10.1002/jcb.10517 · Cited by 15 · see citing works
Berardi, P., Meyyappan, M., & Riabowol, K. T. (2003) · Journal of Biological Chemistry · doi:10.1074/jbc.m210864200 · Cited by 12 · see citing works
Genetic Skin Diseases With Altered Aging
Goldsmith, L. A. (1997) · Archives of Dermatology · doi:10.1001/archderm.133.10.1293 · Cited by 12 · see citing works
Expression of senescence-induced protein WS3-10 in vivo and in vitro
Grigoriev, V. G., Thweatt, R., Moerman, E. J., & Goldstein, S. (1996) · Experimental Gerontology · doi:10.1016/0531-5565(95)02015-2 · Cited by 11 · see citing works
Self-citationGarfinkel, S., Wessendorf, J., Hu, X., & Maciag, T. (1996) · Biochimica et Biophysica Acta (BBA) - Molecular Cell Research · doi:10.1016/s0167-4889(96)00105-x · Cited by 11 · see citing works
Gray, M. D., & Norwood, T. H. (1995) · Reviews in Clinical Gerontology · doi:10.1017/s0959259800004822 · Cited by 7 · see citing works
PAI-1: A Key Signal at the Crossroads of Stem Cell Differentiation and Senescence
Ke, J., Jiang, Y., Cheng, Z., Zhou, Y., Lu, J., Xu, B., Yan, S., & Wang, J. (2025) · International Journal of Molecular Sciences · doi:10.3390/ijms27010086 · Cited by 2 · see citing works
Genetic and Epigenetic Influences on Cutaneous Cellular Senescence
Sarkar, T. J., Hermsmeier, M., Ross, J. L., & Herron, G. S. (2021) · Physiology · doi:10.5772/intechopen.101152 · Cited by 1 · see citing works
Yamamoto, K. (2015) · Japanese Journal of Thrombosis and Hemostasis · doi:10.2491/jjsth.26.265 · Cited by 1 · see citing works
Rizos, H., & Scurr, L. L. (2011) · Springer eBooks · doi:10.1007/978-3-7091-0371-5_11
Rizos, H., Haferkamp, S., & Scurr, L. L. (2017) · Springer eBooks · doi:10.1007/978-3-319-41319-8_11
Senescent cell accumulation & Research-based undergraduate education
Valentijn, F. A. (2022) · doi:10.33540/1121
Zhang, D., Zhang, J.-W., Xu, H., Chen, X., Gao, Y., 江换钢, Wang, Y., Wu, H., Yang, L., Wang, W.-B., et al. (2024) · Figshare · doi:10.6084/m9.figshare.25547109
Zhang, D., Zhang, J.-W., Xu, H., Chen, X., Gao, Y., 江换钢, Wang, Y., Wu, H., Yang, L., Wang, W.-B., et al. (2024) · Figshare · doi:10.6084/m9.figshare.26702080
Zhang, D., Zhang, J.-W., Xu, H., Chen, X., Gao, Y., 江换钢, Wang, Y., Wu, H., Yang, L., Wang, W.-B., et al. (2024) · Figshare · doi:10.6084/m9.figshare.26702095
Zhang, D., Zhang, J.-W., Xu, H., Chen, X., Gao, Y., 江换钢, Wang, Y., Wu, H., Yang, L., Wang, W.-B., et al. (2024) · Figshare · doi:10.6084/m9.figshare.26702077
Zhang, D., Zhang, J.-W., Xu, H., Chen, X., Gao, Y., 江换钢, Wang, Y., Wu, H., Yang, L., Wang, W.-B., et al. (2024) · Figshare · doi:10.6084/m9.figshare.26702071
Zhang, D., Zhang, J.-W., Xu, H., Chen, X., Gao, Y., 江换钢, Wang, Y., Wu, H., Yang, L., Wang, W.-B., et al. (2024) · Figshare · doi:10.6084/m9.figshare.26702086
Zhang, D., Zhang, J.-W., Xu, H., Chen, X., Gao, Y., 江换钢, Wang, Y., Wu, H., Yang, L., Wang, W.-B., et al. (2024) · Figshare · doi:10.6084/m9.figshare.26702092
Zhang, D., Zhang, J.-W., Xu, H., Chen, X., Gao, Y., 江换钢, Wang, Y., Wu, H., Yang, L., Wang, W.-B., et al. (2024) · Figshare · doi:10.6084/m9.figshare.25547062
Zhang, D., Zhang, J.-W., Xu, H., Chen, X., Gao, Y., 江换钢, Wang, Y., Wu, H., Yang, L., Wang, W.-B., et al. (2024) · Figshare · doi:10.6084/m9.figshare.26702083
Zhang, D., Zhang, J.-W., Xu, H., Chen, X., Gao, Y., 江换钢, Wang, Y., Wu, H., Yang, L., Wang, W.-B., et al. (2024) · Figshare · doi:10.6084/m9.figshare.26702074
Zhang, D., Zhang, J.-W., Xu, H., Chen, X., Gao, Y., 江换钢, Wang, Y., Wu, H., Yang, L., Wang, W.-B., et al. (2024) · Figshare · doi:10.6084/m9.figshare.26702089
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Liu, R.-M., & Nakamya, M. F. (2026) · Cells · doi:10.3390/cells15060551
The role of Activin signaling pathway in the initiation and progression of pancreatic cancer
Zhao, Y. (2019) · theses.fr (ABES) · doi:10.70675/17612dbdz6d94z4563z86a3z6d1e91b34f9b
- Authors
- Goldstein, S., Moerman, E. J., Fujii, S., & Sobel, B. E.
- Affiliations
- John L. McClellan Memorial Veterans Hospital (US)
- Washington University in St. Louis (US)
- Corresponding author
- Moerman, Elena J.
- Venue
- Journal of Cellular Physiology
- Publisher
- Wiley
- Published
- 1994-12
- Volume
- 161
- Issue
- 3
- Pages
- 571-579
- ISSN
- 0021-9541 (ISSN-L)
- 1097-4652
- OpenAlex
- W2007249001
- Cited by
- 59
- References
- 31
- Citations by year
- 2026: 1 · 2025: 1 · 2024: 6 · 2022: 1 · 2021: 1 · 2020: 3 · 2019: 2 · 2018: 3 · 2017: 2 · 2015: 3 · 2014: 3 · 2012: 1
- FWCI
- 2.72
- Type
- journal article
- Language
- en
- Open access
- closed
- Locations
- Journal of Cellular Physiology (publishedVersion)
- PubMed (publishedVersion)
- Funders
- National Institutes of Health (5r01ag008708-05)
- National Institute on Aging (AG08708)
- National Heart, Lung, and Blood Institute (HL-17646)
- Topics
- Health Sciences › Medicine › Physiology › Telomeres, Telomerase, and Senescence
- Life Sciences › Biochemistry, Genetics and Molecular Biology › Cancer Research › Protease and Inhibitor Mechanisms
- Life Sciences › Biochemistry, Genetics and Molecular Biology › Aging › Genetics, Aging, and Longevity in Model Organisms
- Keywords
- plasminogen activator inhibitor-1, Werner syndrome, premature senescence, fibroblasts, replicative lifespan, in vivo aging, PAI-1 mRNA expression, conditioned medium, translational regulation, post-translational regulation, thrombus formation, atherogenesis, wound healing
- MeSH terms
- Adult, Aged, Child, Fibroblasts, Humans, Infant, Newborn, Middle Aged, RNA, Messenger, Werner Syndrome, Gene Expression, Cellular Senescence, Plasminogen Activator Inhibitor 1
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