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A Protein Binding Assay for Adenosine 3′:5′-Cyclic Monophosphate
Open accessAbstract
A simple and sensitive assay for adenosine 3′:5′-cyclic monophosphate (cAMP) has been developed that is based on competition for protein binding of the nucleotide, presumably to a cAMP-dependent protein kinase. The nucleotide-protein complex is adsorbed on a cellulose ester filter. Assay conditions are such that a binding constant approaching 10 -9 M is obtained, and the assay is thus sensitive to 0.05-0.10 pmol of cAMP.
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Cited by
The cloning of a family of genes that encode the melanocortin receptors
Mountjoy, K. G., Robbins, L. S., Mortrud, M. T., & Cone, R. D. (1992) · Science · doi:10.1126/science.1325670 · Cited by 1,635
Brown, B. L., Albano, J. D. M., Ekins, R. P., Sgherzi, A. M., & Tampion, W. (1971) · Biochemical Journal · doi:10.1042/bj1210561 · Cited by 1,537
Guerrant, R. L., Brunton, L. L., Schnaitman, T. C., Rebhun, L. I., & Gilman, A. G. (1974) · Infection and Immunity · doi:10.1128/iai.10.2.320-327.1974 · Cited by 560
Self-citationHutson, N. J., Brumley, F. T., Assimacopoulos, F. D., Harper, S. C., & Exton, J. H. (1976) · Journal of Biological Chemistry · doi:10.1016/s0021-9258(17)33147-2 · Cited by 348
Mechanism of Control of Hepatic Glycogenesis by Insulin
Miller, T. B., & Larner, J. (1973) · Journal of Biological Chemistry · doi:10.1016/s0021-9258(19)43955-0 · Cited by 164
Metadata
- Authors
- Gilman, A. G.
- Venue
- Proceedings of the National Academy of Sciences
- Published
- 1970-09
- Volume
- 67
- Issue
- 1
- Pages
- 305-312
- ISSN
- 0027-8424 (ISSN-L)
- 1091-6490
- OpenAlex
- W1996466550
- Cited by
- 3,249
- References
- 0
- FWCI
- 58.38
- Type
- journal article
- Language
- en
- Open access
- green
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Contains information from the Semantic Scholar Academic Graph Datasets, made available under the ODC Attribution License (ODC-BY 1.0).
Semantic Scholar’s data is described in: Kinney, R., et al. (2023). The Semantic Scholar Open Data Platform. arXiv:2301.10140.
