The cloning of a family of genes that encode the melanocortin receptors

Mountjoy, Kathleen G.; Robbins, Linda S.; Mortrud, Marty T.; Cone, Roger D.

doi:10.1126/science.1325670

Cited by 1,635Neuropeptides and Animal PhysiologyReceptor Mechanisms and Signalingmelanin and skin pigmentation

The cloning of a family of genes that encode the melanocortin receptors

Mountjoy, Kathleen G., Robbins, Linda S., Mortrud, Marty T., Cone, Roger D.·1992·Science

DOI 10.1126/science.1325670

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Abstract

Melanocyte-stimulating hormone (MSH) and adrenocorticotropic hormone (ACTH) regulate pigmentation and adrenal cortical function, respectively. These peptides also have a variety of biological activities in other areas, including the brain, the pituitary, and the immune system. A complete understanding of the biological activities of these hormones requires the isolation and characterization of their corresponding receptors. The murine and human MSH receptors (MSH-Rs) and a human ACTH receptor (ACTH-R) were cloned. These receptors define a subfamily of receptors coupled to guanine nucleotide-binding proteins that may include the cannabinoid receptor.

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MC2R is the smallest G protein-coupled receptor at 289 residues.
“The key component of the ACTH receptor complex is the seven transmembrane domain MC2R – perhaps surprisingly, the smallest of all the G protein-coupled receptor (GPCR) family at only 289 residues in length (32).”
From ACTH Antagonists (2016) · cites this paper as [32]

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Authors: Mountjoy, K. G., Robbins, L. S., Mortrud, M. T., & Cone, R. D.
Affiliations: Oregon Health & Science University (US)
ORCID: Mountjoy, Kathleen G.
Cone, Roger D.
Venue: Science
Publisher: American Association for the Advancement of Science (AAAS)
Published: 1992-08-28
Volume: 257
Issue: 5074
Pages: 1248-1251
ISSN: 0036-8075 (ISSN-L)
1095-9203
DOI: 10.1126/science.1325670
OpenAlex: W1979420492
Cited by: 1,635
References: 35
Citations by year: 2026: 19 · 2025: 17 · 2024: 30 · 2023: 26 · 2022: 21 · 2021: 33 · 2020: 28 · 2019: 35 · 2018: 27 · 2017: 40 · 2016: 36 · 2015: 30 · 2014: 53 · 2013: 31 · 2012: 49
FWCI: 19.50
Type: journal article
Language: en
Open access: closed
Locations: Science (publishedVersion)
PubMed (publishedVersion)
Funders: National Institutes of Health (5r01dk043859-02)
National Institute of Diabetes and Digestive and Kidney Diseases (R01 DK43859-02)
Topics: Life Sciences › Neuroscience › Cellular and Molecular Neuroscience › Neuropeptides and Animal Physiology
Life Sciences › Biochemistry, Genetics and Molecular Biology › Molecular Biology › Receptor Mechanisms and Signaling
Life Sciences › Biochemistry, Genetics and Molecular Biology › Cell Biology › melanin and skin pigmentation
Keywords: melanocortin receptors, melanocyte-stimulating hormone, ACTH, receptor cloning, G proteins, cannabinoid receptors, pigmentation, adrenal cortex
MeSH terms: Adrenal Cortex, Amino Acid Sequence, Animals, Cloning, Molecular, Dose-Response Relationship, Drug, Humans, Melanocytes, Molecular Sequence Data, Melanocyte-Stimulating Hormones, Receptors, Pituitary Hormone, RNA, Messenger, Sequence Homology, Nucleic Acid, Blotting, Northern, Polymerase Chain Reaction, Receptors, Corticotropin, GTP-Binding Proteins, Mice

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The cloning of a family of genes that encode the melanocortin receptors

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