The DOI matches its Crossref record; 2 of the 2 references it cites were found in a registry or an index.
T4 Endonuclease Involved in Repair of DNA
Open accessAbstract
An enzyme activity, named T4 endonuclease V, was purified from T4-infected Escherichia coli . The enzyme induces single-stranded breaks in ultraviolet-irradiated DNA but does not act on native or heat-denatured DNA. The enzyme activity is dependent on the dose of ultraviolet irradiation, and the number of the breaks formed is approximately equal to the number of pyrimidine dimers present in the DNA. Denatured DNA, which has been exposed to ultraviolet light, is also attacked by the enzyme although the extent of the reaction is greater with irradiated native DNA. The enzyme shows optimal activity at pH 7.5 and does not require added divalent ions. When the enzyme-treated, irradiated DNA is subjected to stepwise degradation by spleen phosphodiesterase, dimers are released more rapidly than thymine into the acid-soluble fraction, suggesting that the enzyme induces a break at the 5′-side of a pyrimidine dimer. The enzyme, whose formation is controlled by the v + gene of T4, appears to be responsible for the first step of excision repair.
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Citations
Cites
Defective repair replication of DNA in xeroderma pigmentosum
CLEAVER, J. E. (1968) · Nature · doi:10.1038/218652a0 · Cited by 1,729
RELEASE OF ULTRAVIOLET LIGHT-INDUCED THYMINE DIMERS FROM DNA IN E. COLI K-12
Boyce, R. P., & Howard-Flanders, P. (1964) · Proceedings of the National Academy of Sciences · doi:10.1073/pnas.51.2.293 · Cited by 708
Cited by
Chemistry of Glycosylases and Endonucleases Involved in Base-Excision Repair
David, S. S., & Williams, S. D. (1998) · Chemical Reviews · doi:10.1021/cr980321h · Cited by 512
DNA N-glycosylases and UV repair
Demple, B., & Linn, S. (1980) · Nature · doi:10.1038/287203a0 · Cited by 305
Haseltine, W. A., Gordon, L. K., Lindan, C. P., Grafstrom, R. H., Shaper, N. L., & Grossman, L. (1980) · Nature · doi:10.1038/285634a0 · Cited by 302
Tanaka, K., Sekiguchi, M., & Okada, Y. (1975) · Proceedings of the National Academy of Sciences · doi:10.1073/pnas.72.10.4071 · Cited by 209
Self-citationStructures and functions of DNA glycosylases
Sakumi, K., & Sekiguchi, M. (1990) · Mutation Research/DNA Repair · doi:10.1016/0921-8777(90)90003-n · Cited by 106
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Metadata
- Authors
- Yasuda, S., & Sekiguchi, M.
- Venue
- Proceedings of the National Academy of Sciences
- Published
- 1970-12
- Volume
- 67
- Issue
- 4
- Pages
- 1839-1845
- ISSN
- 0027-8424 (ISSN-L)
- 1091-6490
- OpenAlex
- W2040253399
- Cited by
- 170
- References
- 2
- FWCI
- 4.60
- Type
- journal article
- Language
- en
- Open access
- green
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Contains information from the Semantic Scholar Academic Graph Datasets, made available under the ODC Attribution License (ODC-BY 1.0).
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