Restoration of ultraviolet-induced unscheduled DNA synthesis of xeroderma pigmentosum cells by the concomitant treatment with bacteriophage T4 endonuclease V and HVJ (Sendai virus).
Open accessAbstract
Ultraviolet (UV)-induced unscheduled DNA synthesis of xeroderma pigmentosum cells, belonging to complementation groups A, B, C, D, and E, was restored to the normal level by concomitant treatment of the cells with T4 endonuclease V and UV-inactivated HVJ (Sendai virus). The present results suggest that (1) T4 endonuclease molecules were inserted effectively into the cells by the interaction of HVJ with the cell membranes, (2) the enzyme was functional on human chromosomal DNA which had been damaged by UV irradiation in the viable cells, (3) all the studied groups of xeroderma pigmentosum ("variant" was not tested) were defective in the first step (incision) of excision repair.
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- Authors
- Tanaka, K., Sekiguchi, M., & Okada, Y.
- Affiliations
- Kyushu University (JP)
- ORCID
- Venue
- Proceedings of the National Academy of Sciences
- Publisher
- National Academy of Sciences
- Published
- 1975-10
- Volume
- 72
- Issue
- 10
- Pages
- 4071-4075
- ISSN
- 0027-8424 (ISSN-L)
- 1091-6490
- PMC
- PMC433140
- OpenAlex
- W2134213504
- Cited by
- 209
- References
- 24
- Citations by year
- 2026: 1 · 2024: 1 · 2023: 1 · 2021: 3 · 2020: 2 · 2018: 4 · 2017: 2 · 2016: 4 · 2015: 2 · 2014: 2 · 2012: 1
- FWCI
- 5.65
- Type
- journal article
- Language
- en
- Open access
- green
- europepmc.org
- Locations
- Proceedings of the National Academy of Sciences (publishedVersion)
- Europe PMC (PubMed Central) (publishedVersion)
- PubMed Central (publishedVersion)
- PubMed (publishedVersion)
- Topics
- Life Sciences › Biochemistry, Genetics and Molecular Biology › Molecular Biology › DNA Repair Mechanisms
- Life Sciences › Biochemistry, Genetics and Molecular Biology › Cancer Research › Carcinogens and Genotoxicity Assessment
- Life Sciences › Biochemistry, Genetics and Molecular Biology › Molecular Biology › CRISPR and Genetic Engineering
- Keywords
- xeroderma pigmentosum, T4 endonuclease V, Sendai virus, unscheduled DNA synthesis, UV-induced DNA damage, excision repair, DNA incision, complementation groups, UV-inactivated virus
- MeSH terms
- Cells, Cultured, Coliphages, Deoxyribonucleases, DNA Replication, DNA, Neoplasm, Endonucleases, Humans, Parainfluenza Virus 1, Human, Radiation Effects, Ultraviolet Rays, Xeroderma Pigmentosum
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