The DOI matches its Crossref record; 1 of the 1 references it cites were found in a registry or an index.
Repression of the Overproduction of Porphyrin Precursors in Acute Intermittent Porphyria by Intravenous Infusions of Hematin
Open accessAbstract
In a patient with a severe attack of acute intermittent porphyria, hematin given intravenously caused marked diminution of serum δ-aminolevulinic acid and porphobilinogen. The decline of aminolevulinate was more rapid than that of porphobilinoge. After 2 days of hematin administration, about 5 days were required for δ-aminolevulinic acid, and 11 days for porphobilinogen to return to the concentrations that were detected before treatment. Urinary excretion of both compounds also decreased after hematin administration. Considerable amounts of porphobilinogen were also found in the cerebrospinal fluid of the patient.
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Citations
Cites
The metabolism of δ-aminolaevulic acid. 1. Normal pathways, studied with the aid of 15N
Berlin, N. I., Neuberger, A., & Scott, J. J. (1956) · Biochemical Journal · doi:10.1042/bj0640080 · Cited by 126
Cited by
Drummond, G. S., & Kappas, A. (1981) · Proceedings of the National Academy of Sciences · doi:10.1073/pnas.78.10.6466 · Cited by 279
Clinical guide and update on porphyrias
Stölzel, U., Doss, M. O., & Schuppan, D. (2019) · Gastroenterology · doi:10.1053/j.gastro.2019.04.050 · Cited by 175
Chan, A., Liebow, A., Yasuda, M., Gan, L., Racie, T., Maier, M., Kuchimanchi, S., Foster, D., Milstein, S., Charisse, K., et al. (2015) · Molecular Therapy — Nucleic Acids · doi:10.1038/mtna.2015.36 · Cited by 128
Metadata
- Authors
- Bonkowsky, H. L., Tschudy, D. P., Collins, A., Doherty, J., Bossenmaier, I., Cardinal, R., & Watson, C. J.
- Venue
- Proceedings of the National Academy of Sciences
- Published
- 1971-11
- Volume
- 68
- Issue
- 11
- Pages
- 2725-2729
- ISSN
- 0027-8424 (ISSN-L)
- 1091-6490
- OpenAlex
- W2026148018
- Cited by
- 203
- References
- 1
- FWCI
- 1.77
- Type
- journal article
- Language
- en
- Open access
- green
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- CoChat. (2026). Citation check: Repression of the Overproduction of Porphyrin Precursors in Acute Intermittent Porphyria by Intravenous Infusions of Hematin. https://app.cochat.ai/papers/10.1073/pnas.68.11.2725
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- Bonkowsky, H. L., Tschudy, D. P., Collins, A., Doherty, J., Bossenmaier, I., Cardinal, R., & Watson, C. J. (1971). Repression of the Overproduction of Porphyrin Precursors in Acute Intermittent Porphyria by Intravenous Infusions of Hematin. Proceedings of the National Academy of Sciences. https://doi.org/10.1073/pnas.68.11.2725
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Contains information from the Semantic Scholar Academic Graph Datasets, made available under the ODC Attribution License (ODC-BY 1.0).
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