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Sequences of Pituitary and Placental Lactogenic and Growth Hormones: Evolution from a Primordial Peptide by Gene Reduplication
Open accessAbstract
Human placental lactogen has been found to resemble human pituitary growth hormone very closely in amino acid sequence, about 80% of the residues examined being identical in the two molecules when a revised sequence for growth hormone is used as the basis for comparison. The structural features responsible for the differing biological potency of the two hormones may therefore reside in rather limited regions of primary structure. The observation of internal sequence homologies within the pituitary growth hormone and prolactin and the placental lactogen molecules suggests that these polypeptide hormones may have evolved by genetic reduplication from a smaller common ancestral peptide. This finding directs further attention to subfragments of these molecules as possible possessors of intrinsic somatotrophic and lactogenic activity.
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Citations
Cited by
Prolactin: structure, function, and regulation of secretion
Freeman, M. E., Kanyicska, B., Lerant, A., & Nagy, G. (2000) · Physiological Reviews · doi:10.1152/physrev.2000.80.4.1523 · Cited by 2,457
The Somatomedin Hypothesis: 2001
Le Roith, D., Bondy, C., Yakar, S., Liu, J.-L., & Butler, A. (2001) · Endocrine Reviews · doi:10.1210/edrv.22.1.0419 · Cited by 1,257
Human Growth Hormone: Complementary DNA Cloning and Expression in Bacteria
Martial, J. A., Hallewell, R. A., Baxter, J. D., & Goodman, H. M. (1979) · Science · doi:10.1126/science.377496 · Cited by 401
GOFFIN, V., SHIVERICK, K. T., KELLY, P. A., & MARTIAL, J. A. (1996) · Endocrine Reviews · doi:10.1210/edrv-17-4-385 · Cited by 293
Evolution of GnRH: Diving deeper
Roch, G. J., Busby, E. R., & Sherwood, N. M. (2011) · General and Comparative Endocrinology · doi:10.1016/j.ygcen.2010.12.014 · Cited by 225
Metadata
- Authors
- Niall, H. D., Hogan, M. L., Sauer, R., Rosenblum, I. Y., & Greenwood, F. C.
- Venue
- Proceedings of the National Academy of Sciences
- Published
- 1971-04
- Volume
- 68
- Issue
- 4
- Pages
- 866-869
- ISSN
- 0027-8424 (ISSN-L)
- 1091-6490
- OpenAlex
- W2011182863
- Cited by
- 372
- References
- 0
- FWCI
- 17.58
- Type
- journal article
- Language
- en
- Open access
- green
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- CoChat. (2026). Citation check: Sequences of Pituitary and Placental Lactogenic and Growth Hormones: Evolution from a Primordial Peptide by Gene Reduplication. https://app.cochat.ai/papers/10.1073/pnas.68.4.866
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- Niall, H. D., Hogan, M. L., Sauer, R., Rosenblum, I. Y., & Greenwood, F. C. (1971). Sequences of Pituitary and Placental Lactogenic and Growth Hormones: Evolution from a Primordial Peptide by Gene Reduplication. Proceedings of the National Academy of Sciences. https://doi.org/10.1073/pnas.68.4.866
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Contains information from the Semantic Scholar Academic Graph Datasets, made available under the ODC Attribution License (ODC-BY 1.0).
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