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Folding of Polypeptide Chains in Proteins: A Proposed Mechanism for Folding
Open accessAbstract
A mechanism is proposed for the folding of protein chains. On the basis of short-range interactions, certain aminoacid sequences have a high propensity to be, say, α-helical. However, these short helical (or other ordered) regions can be stabilized only by long-range interactions arising from the proximity of two such ordered regions. These regions are brought near each other by the directing influence of certain other aminoacid sequences that have a high probability of forming β-bends or variants thereof, also on the basis of short-range interactions. An analysis is made of the tendency of various amino acids to occur in β-bends, and it is possible to predict the regions of a chain in which a β-bend will occur with a high degree of reliability.
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Citations
Cited by
The Anatomy and Taxonomy of Protein Structure
Richardson, J. S. (1981) · Advances in Protein Chemistry · doi:10.1016/s0065-3233(08)60520-3 · Cited by 3,375
Soluble Protein of the Organic Matrix of Mollusk Shells: A Potential Template for Shell Formation
Weiner, S., & Hood, L. (1975) · Science · doi:10.1126/science.1188379 · Cited by 377
Hypothesis about the function of membrane-buried proline residues in transport proteins.
Brandl, C. J., & Deber, C. M. (1986) · Proceedings of the National Academy of Sciences · doi:10.1073/pnas.83.4.917 · Cited by 337
Metadata
- Authors
- Lewis, P. N., Momany, F. A., & Scheraga, H. A.
- Venue
- Proceedings of the National Academy of Sciences
- Published
- 1971-09
- Volume
- 68
- Issue
- 9
- Pages
- 2293-2297
- ISSN
- 0027-8424 (ISSN-L)
- 1091-6490
- OpenAlex
- W2018645145
- Cited by
- 312
- References
- 0
- FWCI
- 5.50
- Type
- journal article
- Language
- en
- Open access
- green
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- CoChat. (2026). Citation check: Folding of Polypeptide Chains in Proteins: A Proposed Mechanism for Folding. https://app.cochat.ai/papers/10.1073/pnas.68.9.2293
- The paper
- Lewis, P. N., Momany, F. A., & Scheraga, H. A. (1971). Folding of Polypeptide Chains in Proteins: A Proposed Mechanism for Folding. Proceedings of the National Academy of Sciences. https://doi.org/10.1073/pnas.68.9.2293
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Contains information from the Semantic Scholar Academic Graph Datasets, made available under the ODC Attribution License (ODC-BY 1.0).
Semantic Scholar’s data is described in: Kinney, R., et al. (2023). The Semantic Scholar Open Data Platform. arXiv:2301.10140.
