The DOI matches its Crossref record; 4 of the 4 references it cites were found in a registry or an index.
Purification and Properties of Biologically Active Messenger RNA for a Myeloma Light Chain
Open accessAbstract
A cell-free system derived from Krebs II ascites tumor has been used to assay biologically active mRNA for myeloma (MOPC-41) light chain during its purification by oligothymidylate-cellulose chromatography and sucrose gradient centrifugation. The purified mRNA directs the synthesis of a product that yields tryptic peptides corresponding to those derived from authentic myeloma protein and that forms a specific immunoprecipitate with antibody directed against the MOPC-41 protein. The fact that the light-chain mRNA anneals to oligothymidylic acid-cellulose suggests that it, like several other eukaryotic mRNAs, contains a region rich in adenylic acid residues. The most active fractions of light-chain mRNA, representing about 0.1% of the RNA originally extracted from membrane-bound myeloma polysomes, sediment as a discrete peak with an s 20, w of about 13, roughly corresponding to an RNA molecule containing 850 bases. The results suggest that the light-chain mRNA is monocistronic and that it contains about 200 more bases than would be necessary to encode the variable and constant regions of a single light-chain molecule.
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Cites
Edmonds, M., Vaughan, M. H., & Nakazato, H. (1971) · Proceedings of the National Academy of Sciences · doi:10.1073/pnas.68.6.1336 · Cited by 510
In vitro Synthesis of DNA Complementary to Rabbit Reticulocyte 10S RNA
VERMA, I. M., TEMPLE, G. F., FAN, H., & BALTIMORE, D. (1972) · Nature New Biology · doi:10.1038/newbio235163a0 · Cited by 237
In Vitro Synthesis of DNA Complementary to Purified Rabbit Globin mRNA
Ross, J., Aviv, H., Scolnick, E., & Leder, P. (1972) · Proceedings of the National Academy of Sciences · doi:10.1073/pnas.69.1.264 · Cited by 192
Self-citationIn vitro Synthesis of DNA Components of Human Genes for Globins
KACIAN, D. L., SPIEGELMAN, S., BANK, A., TERADA, M., METAFORA, S., DOW, L., & MARKS, P. A. (1972) · Nature New Biology · doi:10.1038/newbio235167a0 · Cited by 173
Cited by
Roberts, B. E., & Paterson, B. M. (1973) · Proceedings of the National Academy of Sciences · doi:10.1073/pnas.70.8.2330 · Cited by 1,208
Sequence of a mouse germ-line gene for a variable region of an immunoglobulin light chain.
Tonegawa, S., Maxam, A. M., Tizard, R., Bernard, O., & Gilbert, W. (1978) · Proceedings of the National Academy of Sciences · doi:10.1073/pnas.75.3.1485 · Cited by 414
Metadata
- Authors
- Swan, D., Aviv, H., & Leder, P.
- Venue
- Proceedings of the National Academy of Sciences
- Published
- 1972-07
- Volume
- 69
- Issue
- 7
- Pages
- 1967-1971
- ISSN
- 0027-8424 (ISSN-L)
- 1091-6490
- OpenAlex
- W2015880687
- Cited by
- 196
- References
- 4
- FWCI
- 15.82
- Type
- journal article
- Language
- en
- Open access
- green
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