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Cited by 659

The DOI matches its Crossref record; 1 of the 1 references it cites were found in a registry or an index.

Alteration of Cell-Surface Proteins by Viral Transformation and by Proteolysis

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Hynes, Richard O.·1973·Proceedings of the National Academy of Sciences

Abstract

Putative cell-surface proteins of tissue-culture cells were identified by lactoperoxidase-catalyzed iodination, a technique that attaches label only to proteins outside the cell membrane. Evidence is presented that these proteins are cell derived, not contaminating serum proteins. On “normal” cells, which exhibit density dependence of growth, one protein of high molecular weight was particularly readily iodinated. This protein was easily removed by mild proteolytic digestion, and, in virus-transformed cells, was either absent or unavailable for iodination. The possible relevance of these observations to the control of growth in cell culture is discussed.

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Metadata

Authors
Hynes, R. O.
Venue
Proceedings of the National Academy of Sciences
Published
1973-11
Volume
70
Issue
11
Pages
3170-3174
ISSN
  • 0027-8424 (ISSN-L)
  • 1091-6490
OpenAlex
W1963631969
Cited by
659
References
1
FWCI
25.68
Type
journal article
Language
en
Open access
green

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CoChat. (2026). Citation check: Alteration of Cell-Surface Proteins by Viral Transformation and by Proteolysis. https://app.cochat.ai/papers/10.1073/pnas.70.11.3170
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Hynes, R. O. (1973). Alteration of Cell-Surface Proteins by Viral Transformation and by Proteolysis. Proceedings of the National Academy of Sciences. https://doi.org/10.1073/pnas.70.11.3170

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Contains information from the Semantic Scholar Academic Graph Datasets, made available under the ODC Attribution License (ODC-BY 1.0).

Semantic Scholar’s data is described in: Kinney, R., et al. (2023). The Semantic Scholar Open Data Platform. arXiv:2301.10140.