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Bone Morphogenesis in Implants of Insoluble Bone Gelatin
Open accessAbstract
Insoluble bone gelatin with inclusions of insoluble noncollagenous protein produces new bone when implanted in muscle in allogeneic rats. The implanted residue provides the milieu for expression of bone morphogenetic potential of migratory mesenchymal cells. Neutral buffer solutions activate endogenous enzymes that degrade components essential for cell interactions and differentiation of bone. Chloroform-methanol either denatures or extracts constituents responsible for degradation. Insoluble bone gelatin produces new bone after extraction at 2° with neutral salts, 0.5 M EDTA, 0.1 M Tris·HCl, 4 M urea, 0.5 M hydroxylamine, and 10 M KCNS, as well as after limited digestion with pepsin or collagenase, but not after extraction with 5 M guanidine, 7 M urea, water saturated with phenol, or after alkali hydrolysis with 0.1 N NaOH. The specific activity of cell populations interacting with insoluble bone gelatin suggests that a chemical bond between collagen and a noncollagenous protein or part of a protein, cleaved by a neutral proteinase, controls the bone morphogenetic reaction.
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Citations
Cited by
Bone Cell Differentiation and Growth Factors
Urist, M. R., DeLange, R. J., & Finerman, G. A. M. (1983) · Science · doi:10.1126/science.6403986 · Cited by 873
Self-citationFiorellini, J. P., Howell, T. H., Cochran, D., Malmquist, J., Lilly, L. C., Spagnoli, D., Toljanic, J., Jones, A., & Nevins, M. (2005) · Journal of Periodontology · doi:10.1902/jop.2005.76.4.605 · Cited by 391
PDGF in bone formation and regeneration: New insights into a novel mechanism involving MSCs
Caplan, A. I., & Correa, D. (2011) · Journal of Orthopaedic Research · doi:10.1002/jor.21462 · Cited by 312
Method Development of Efficient Protein Extraction in Bone Tissue for Proteome Analysis
Jiang, X., Ye, M., Jiang, X., Liu, G., Feng, S., Cui, L., & Zou, H. (2007) · Journal of Proteome Research · doi:10.1021/pr070056t · Cited by 144
Yang, B., Yin, Z., Cao, J., Shi, Z., Zhang, Z., Song, H., Liu, F., & Caterson, B. (2010) · Biomedical Materials · doi:10.1088/1748-6041/5/4/045003 · Cited by 20
Metadata
- Authors
- Urist, M. R., Iwata, H., Ceccotti, P. L., Dorfman, R. L., Boyd, S. D., McDowell, R. M., & Chien, C.
- Venue
- Proceedings of the National Academy of Sciences
- Published
- 1973-12
- Volume
- 70
- Issue
- 12
- Pages
- 3511-3515
- ISSN
- 0027-8424 (ISSN-L)
- 1091-6490
- OpenAlex
- W2085463192
- Cited by
- 242
- References
- 0
- FWCI
- 8.34
- Type
- journal article
- Language
- en
- Open access
- green
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- Urist, M. R., Iwata, H., Ceccotti, P. L., Dorfman, R. L., Boyd, S. D., McDowell, R. M., & Chien, C. (1973). Bone Morphogenesis in Implants of Insoluble Bone Gelatin. Proceedings of the National Academy of Sciences. https://doi.org/10.1073/pnas.70.12.3511
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Contains information from the Semantic Scholar Academic Graph Datasets, made available under the ODC Attribution License (ODC-BY 1.0).
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