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The Nucleotide Sequence of the lac Operator
Open accessAbstract
The lac repressor protects the lac operator against digestion with deoxyribonuclease. The protected fragment is double-stranded and about 27 base-pairs long. We determined the sequence of RNA transcription copies of this fragment and present a sequence for 24 base pairs. It is: 5′--T G G A A T T G T G A G C G G A T A A C A A T T 3′ 3′--A C C T T A A C A C T C G C C T A T T G T T A A 5′ The sequence has 2-fold symmetry regions; the two longest are separated by one turn of the DNA double helix.
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Citations
Cited by
Maniatis, T., Jeffrey, A., & Van deSande, H. (1975) · Biochemistry · doi:10.1021/bi00688a010 · Cited by 1,121
Bagg, A., & Neilands, J. B. (1987) · Biochemistry · doi:10.1021/bi00391a039 · Cited by 593
Historical perspective, development and applications of next-generation sequencing in plant virology
Barba, M., Czosnek, H., & Hadidi, A. (2014) · Viruses · doi:10.3390/v6010106 · Cited by 317
“In 1973, the first nucleotide sequence of 24 bp out of 27 bp of the lac operator DNA was published [8].”
BackgroundAn aminoacyl tRNA synthetase binds to a specific DNA sequence and regulates its gene transcription
Putney, S. D., & Schimmel, P. (1981) · Nature · doi:10.1038/291632a0 · Cited by 155
Metadata
- Authors
- Gilbert, W., & Maxam, A.
- Venue
- Proceedings of the National Academy of Sciences
- Published
- 1973-12
- Volume
- 70
- Issue
- 12
- Pages
- 3581-3584
- ISSN
- 0027-8424 (ISSN-L)
- 1091-6490
- OpenAlex
- W2073874317
- Cited by
- 485
- References
- 0
- FWCI
- 31.25
- Type
- journal article
- Language
- en
- Open access
- green
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