The DOI matches its Crossref record; 15 of the 15 references it cites were found in a registry or an index.
Segregation During Ascidian Embryogenesis of Egg Cytoplasmic Information for Tissue-Specific Enzyme Development
Open accessAbstract
Cleavage-arrested embryos of the ascidian Ciona intestinalis were able to differentiate two tissue-specific enzymes—muscle acetylcholinesterase (EC 3.1.1.7) and brain pigment cell tyrosinase (EC 1.10.3.1). Cytochalasin B, colchicine, Colcemid, and podophyllotoxin were used as cleavage inhibitors at early embryonic stages up to the 64-cell stage. Only certain cells in the cleavage-arrested embryos developed these histochemically detectable enzymes, and this ability followed the cell lineage patterns for the two tissues. This result implies the presence of specific positional information in the egg cytoplasm that is differentially segregated during cleavage. There were distinct and separate puromycin and actinomycin D sensitivity periods for the occurrence of each enzyme during development of both normal and cleavage-arrested embryos. The segregated information is apparently neither the enzyme proteins nor RNA templates for enzyme synthesis, but is probably concerned with activation of appropriate genes.
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Cites
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Cited by
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How embryos work: a comparative view of diverse modes of cell fate specification
Davidson, E. H. (1990) · Development · doi:10.1242/dev.108.3.365 · Cited by 267
macho-1 encodes a localized mRNA in ascidian eggs that specifies muscle fate during embryogenesis
Nishida, H., & Sawada, K. (2001) · Nature · doi:10.1038/35055568 · Cited by 259
Spatial mechanisms of gene regulation in metazoan embryos
Davidson, E. H. (1991) · Development · doi:10.1242/dev.113.1.1 · Cited by 233
Metadata
- Authors
- Whittaker, J. R.
- Venue
- Proceedings of the National Academy of Sciences
- Published
- 1973-07
- Volume
- 70
- Issue
- 7
- Pages
- 2096-2100
- ISSN
- 0027-8424 (ISSN-L)
- 1091-6490
- OpenAlex
- W1979050181
- Cited by
- 278
- References
- 15
- FWCI
- 3.07
- Type
- journal article
- Language
- en
- Open access
- green
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Bibliographic data: Semantic Scholar, OpenAlex, Crossref.
Contains information from the Semantic Scholar Academic Graph Datasets, made available under the ODC Attribution License (ODC-BY 1.0).
Semantic Scholar’s data is described in: Kinney, R., et al. (2023). The Semantic Scholar Open Data Platform. arXiv:2301.10140.
