The DOI matches its Crossref record; 1 of the 1 references it cites were found in a registry or an index.
Carcinogens are Mutagens: A Simple Test System Combining Liver Homogenates for Activation and Bacteria for Detection
Open accessAbstract
18 Carcinogens, including aflatoxin B 1 , benzo(a)pyrene, acetylaminofluorene, benzidine, and dimethylamino- trans -stilbene, are shown to be activated by liver homogenates to form potent frameshift mutagens. We believe that these carcinogens have in common a ring system sufficiently planar for a stacking interaction with DNA base pairs and a part of the molecule capable of being metabolized to a reactive group: these structural features are discussed in terms of the theory of frameshift mutagenesis. We propose that these carcinogens, and many others that are mutagens, cause cancer by somatic mutation. A simple, inexpensive, and extremely sensitive test for detection of carcinogens as mutagens is described. It consists of the use of a rat or human liver homogenate for carcinogen activation (thus supplying mammalian metabolism) and a set of Salmonella histidine mutants for mutagen detection. The homogenate, bacteria, and a TPNH-generating system are all incubated together on a petri plate. With the most active compounds, as little as a few nanograms can be detected.
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Citations
Cites
Frameshift Mutations and the Genetic Code
Streisinger, G., Okada, Y., Emrich, J., Newton, J., Tsugita, A., Terzaghi, E., & Inouye, M. (1966) · Cold Spring Harbor Symposia on Quantitative Biology · doi:10.1101/sqb.1966.031.01.014 · Cited by 1,400
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van der Meer, J. R., & Belkin, S. (2010) · Nature Reviews Microbiology · doi:10.1038/nrmicro2392 · Cited by 533
Hajisharifi, Z., Piryaiee, M., Mohammad Beigi, M., Behbahani, M., & Mohabatkar, H. (2014) · Journal of Theoretical Biology · doi:10.1016/j.jtbi.2013.08.037 · Cited by 294
Current trends in biocompatibility testing
Kirkpatrick, C. J., Bittinger, F., Wagner, M., Köhler, H., van Kooten, T. G., Klein, C. L., & Otto, M. (1998) · Proceedings of the Institution of Mechanical Engineers, Part H: Journal of Engineering in Medicine · doi:10.1243/0954411981533845 · Cited by 145
Epidemiology, multistage models, and short-term mutagenicity tests
Peto, R. (2016) · International Journal of Epidemiology · doi:10.1093/ije/dyv199 · Cited by 68
Metadata
- Authors
- Ames, B. N., Durston, W. E., Yamasaki, E., & Lee, F. D.
- Venue
- Proceedings of the National Academy of Sciences
- Published
- 1973-08
- Volume
- 70
- Issue
- 8
- Pages
- 2281-2285
- ISSN
- 0027-8424 (ISSN-L)
- 1091-6490
- OpenAlex
- W2004678494
- Cited by
- 2,276
- References
- 1
- FWCI
- 59.99
- Type
- journal article
- Language
- en
- Open access
- green
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- Ames, B. N., Durston, W. E., Yamasaki, E., & Lee, F. D. (1973). Carcinogens are Mutagens: A Simple Test System Combining Liver Homogenates for Activation and Bacteria for Detection. Proceedings of the National Academy of Sciences. https://doi.org/10.1073/pnas.70.8.2281
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Contains information from the Semantic Scholar Academic Graph Datasets, made available under the ODC Attribution License (ODC-BY 1.0).
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