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Structure of Liver Alcohol Dehydrogenase at 2.9-Å Resolution
Open accessAbstract
The conformation of the polypeptide chain in horse liver alcohol dehydrogenase (EC 1.1.1.1), as well as the binding sites for some inhibitor molecules, have been determined from x-ray crystallographic data to a resolution of 2.9 Å. Each subunit of the dimeric molecule is organized into two parts unequal in size and separated by a wide and deep active-site cleft. The adenosine moiety of the coenzyme is bound within the smaller region. Interactions between these coenzyme-binding substructures define the subunit contact area of the molecule. The “catalytic” zinc atoms are bound at the bottom of the clefts about 20 Å from the surface of the molecule. The coenzyme binding region has a main-chain conformation very similar to a corresponding region in lactate and malate dehydrogenase. It is suggested that this substructure is a general one for binding of nucleotides and, in particular, the coenzyme NAD + .
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Cited by
Kavanagh, K. L., Jörnvall, H., Persson, B., & Oppermann, U. (2008) · Cellular and Molecular Life Sciences · doi:10.1007/s00018-008-8588-y · Cited by 908
Three-dimensional structure of Escherichia coli thioredoxin-S2 to 2.8 A resolution.
Holmgren, A., Söderberg, B. O., Eklund, H., & Brändén, C. I. (1975) · Proceedings of the National Academy of Sciences · doi:10.1073/pnas.72.6.2305 · Cited by 438
Self-citationZinc binding in proteins and solution: A simple but accurate nonbonded representation
Stote, R. H., & Karplus, M. (1995) · Proteins: Structure, Function, and Bioinformatics · doi:10.1002/prot.340230104 · Cited by 354
NAD-binding domains of dehydrogenases
Lesk, A. M. (1995) · Current Opinion in Structural Biology · doi:10.1016/0959-440x(95)80010-7 · Cited by 239
Metadata
- Authors
- Brändén, C.-I., Eklund, H., Nordström, B., Boiwe, T., Söderlund, G., Zeppezauer, E., Ohlsson, I., & Åkeson, Å.
- Venue
- Proceedings of the National Academy of Sciences
- Published
- 1973-08
- Volume
- 70
- Issue
- 8
- Pages
- 2439-2442
- ISSN
- 0027-8424 (ISSN-L)
- 1091-6490
- OpenAlex
- W2002310840
- Cited by
- 185
- References
- 0
- FWCI
- 40.50
- Type
- journal article
- Language
- en
- Open access
- green
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- CoChat. (2026). Citation check: Structure of Liver Alcohol Dehydrogenase at 2.9-Å Resolution. https://app.cochat.ai/papers/10.1073/pnas.70.8.2439
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- Brändén, C.-I., Eklund, H., Nordström, B., Boiwe, T., Söderlund, G., Zeppezauer, E., Ohlsson, I., & Åkeson, Å. (1973). Structure of Liver Alcohol Dehydrogenase at 2.9-Å Resolution. Proceedings of the National Academy of Sciences. https://doi.org/10.1073/pnas.70.8.2439
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Contains information from the Semantic Scholar Academic Graph Datasets, made available under the ODC Attribution License (ODC-BY 1.0).
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