The DOI matches its Crossref record; 19 of the 19 references it cites were found in a registry or an index.
Three-dimensional structure of Escherichia coli thioredoxin-S2 to 2.8 A resolution.
Open accessAbstract
The three-dimensional structure of the electron transport protein thioredoxin-S2 from E. coli has been determined from a 2.8 A resolution electron density map. The molecule is built up of a central core of three parallel and two antiparallel strands of pleated sheet surrounded by four helices. Thr residues involved in the active center 14-membered disulfide ring of thioredoxin form a protrusion between one of the helices and the middle strand of the pleated sheet. This region of the molecule, comprising two parallel strands joined by the protrusion and a helix, is structurally very similar to corresponding functionally important regions in the nucleotide-binding domains of flavodoxin and the dehydrogenases. The molecule has about 75% of the residues in well-defined secondary structures. The structure indicates that the carboxy-terminal third of the molecule forms an independent folding unit consisting of two strands of antiparallel pleated sheet and a terminal alpha-helix. This agress with the noncovalent reconstitution experiments from thioredoxin peptide fragments. Thioredoxin is an example of a protein with the active center located on a protrusion rather than in a cleft, thus demonstrating the existence of male proteins.
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Cites
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The matching of physical models to three-dimensional electron-density maps: A simple optical device
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Thioredoxin. 6. The Amino Acid Sequence of the Protein from Escherichia coli B
Holmgren, A. (1968) · European Journal of Biochemistry · doi:10.1111/j.1432-1033.1968.tb00470.x · Cited by 278
Self-citationThree-dimensional structure of adenyl kinase
Schulz, G. E., Elzinga, M., Marx, F., & Schirmer, R. H. (1974) · Nature · doi:10.1038/250120a0 · Cited by 256
Structure of Lactate Dehydrogenase at 2.8 Å Resolution
ADAMS, M. J., FORD, G. C., KOEKOEK, R., LENTZ, P. J., McPHERSON, A., ROSSMANN, M. G., SMILEY, I. E., SCHEVITZ, R. W., & WONACOTT, A. J. (1970) · Nature · doi:10.1038/2271098a0 · Cited by 237
Structure of Liver Alcohol Dehydrogenase at 2.9-Å Resolution
Brändén, C.-I., Eklund, H., Nordström, B., Boiwe, T., Söderlund, G., Zeppezauer, E., Ohlsson, I., & Åkeson, Å. (1973) · Proceedings of the National Academy of Sciences · doi:10.1073/pnas.70.8.2439 · Cited by 185
Self-citationAn Immunologic Approach to the Conformational Equilibria of Polypeptides
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Cited by
The Anatomy and Taxonomy of Protein Structure
Richardson, J. S. (1981) · Advances in Protein Chemistry · doi:10.1016/s0065-3233(08)60520-3 · Cited by 3,375
Thioredoxin and Related Molecules–From Biology to Health and Disease
Lillig, C. H., & Holmgren, A. (2007) · Antioxidants & Redox Signaling · doi:10.1089/ars.2007.9.25 · Cited by 724
Self-citationThioredoxin and glutathione regulate photosynthesis in chloroplasts
WOLOSIUK, R. A., & BUCHANAN, B. B. (1977) · Nature · doi:10.1038/266565a0 · Cited by 344
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Self-citationThioredoxin and Thioredoxin Reductase in Relation to Reversible S -Nitrosylation
Sengupta, R., & Holmgren, A. (2013) · Antioxidants & Redox Signaling · doi:10.1089/ars.2012.4716 · Cited by 156
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Metadata
- Authors
- Holmgren, A., Söderberg, B. O., Eklund, H., & Brändén, C. I.
- Venue
- Proceedings of the National Academy of Sciences
- Published
- 1975-06
- Volume
- 72
- Issue
- 6
- Pages
- 2305-2309
- ISSN
- 0027-8424 (ISSN-L)
- 1091-6490
- OpenAlex
- W2078794355
- Cited by
- 438
- References
- 19
- FWCI
- 10.93
- Type
- journal article
- Language
- en
- Open access
- green
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- Holmgren, A., Söderberg, B. O., Eklund, H., & Brändén, C. I. (1975). Three-dimensional structure of Escherichia coli thioredoxin-S2 to 2.8 A resolution. Proceedings of the National Academy of Sciences. https://doi.org/10.1073/pnas.72.6.2305
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Contains information from the Semantic Scholar Academic Graph Datasets, made available under the ODC Attribution License (ODC-BY 1.0).
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