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The Three Dimensional Structure of the Lysozyme from Bacteriophage T4
Open accessAbstract
The three dimensional structure of the lysozyme from bacteriophage T4 has been determined from a 2.5 Å resolution electron density map. About 60% of the molecule is in a helical conformation and there is one region consisting of antiparallel β-structure. The polypeptide backbone folds into two distinct lobes linked in part by a long helix. In the region between the two lobes, there is a cleft which deepens into a hole or cavity, about 6-8 Å in diameter, extending from one side of the molecule to the other. This opening is closed off by side chains which extend to within 3-5 Å of each other. A number of mutant lysozymes in which residues in the vicinity of the opening are modified have markedly reduced catalytic activity, suggesting that this region of the molecule may be catalytically important. The three dimensional structure of T4 phage lysozyme is quite different from that of hen egg-white lysozyme although it is not clear at this time whether or not the mechanisms of catalysis of the respective enzymes are related.
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Cites
Frameshift Mutations and the Genetic Code
Streisinger, G., Okada, Y., Emrich, J., Newton, J., Tsugita, A., Terzaghi, E., & Inouye, M. (1966) · Cold Spring Harbor Symposia on Quantitative Biology · doi:10.1101/sqb.1966.031.01.014 · Cited by 1,400
Cited by
The Anatomy and Taxonomy of Protein Structure
Richardson, J. S. (1981) · Advances in Protein Chemistry · doi:10.1016/s0065-3233(08)60520-3 · Cited by 3,375
Troponin and Parvalbumin Calcium Binding Regions Predicted in Myosin Light Chain and T4 Lysozyme
Tufty, R. M., & Kretsinger, R. H. (1975) · Science · doi:10.1126/science.1111094 · Cited by 375
Lessons from the lysozyme of phage T4
Baase, W. A., Liu, L., Tronrud, D. E., & Matthews, B. W. (2010) · Protein Science · doi:10.1002/pro.344 · Cited by 199
Self-citationA Covalent Enzyme-Substrate Intermediate with Saccharide Distortion in a Mutant T4 Lysozyme
Kuroki, R., Weaver, L. H., & Matthews, B. W. (1993) · Science · doi:10.1126/science.8266098 · Cited by 193
Self-citationDirect Observation of T4 Lysozyme Hinge-Bending Motion by Fluorescence Correlation Spectroscopy
Yirdaw, R. B., & Mchaourab, H. S. (2012) · Biophysical Journal · doi:10.1016/j.bpj.2012.07.053 · Cited by 29
Metadata
- Authors
- Matthews, B. W., & Remington, S. J.
- Venue
- Proceedings of the National Academy of Sciences
- Published
- 1974-10
- Volume
- 71
- Issue
- 10
- Pages
- 4178-4182
- ISSN
- 0027-8424 (ISSN-L)
- 1091-6490
- OpenAlex
- W2018529040
- Cited by
- 176
- References
- 1
- FWCI
- 5.05
- Type
- journal article
- Language
- en
- Open access
- green
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- Matthews, B. W., & Remington, S. J. (1974). The Three Dimensional Structure of the Lysozyme from Bacteriophage T4. Proceedings of the National Academy of Sciences. https://doi.org/10.1073/pnas.71.10.4178
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Contains information from the Semantic Scholar Academic Graph Datasets, made available under the ODC Attribution License (ODC-BY 1.0).
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