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The Three-Dimensional Structure of a Phosphorylcholine-Binding Mouse Immunoglobulin Fab and the Nature of the Antigen Binding Site
Open accessAbstract
The structure of the Fab of McPC 603, a mouse myeloma protein with phosphorylcholine binding activity, has been determined to 3.1-Å resoltuion. The four domains are found to be structurally similar with a well-defined double-layer structure. A large cavity exists at one end of the fragment, the walls of which are formed exclusively of hypervariable residues. Phosphorylcholine binds in this cavity and forms specific interactions with several well-defined amino-acid side chains of the protein. The hapten is bound asymmetrically and interacts more with the heavy chain than with the light chain.
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Citations
Cites
Wu, T. T., & Kabat, E. A. (1970) · The Journal of Experimental Medicine · doi:10.1084/jem.132.2.211 · Cited by 1,340
Cited by
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Replacing the complementarity-determining regions in a human antibody with those from a mouse
Jones, P. T., Dear, P. H., Foote, J., Neuberger, M. S., & Winter, G. (1986) · Nature · doi:10.1038/321522a0 · Cited by 1,406
Three-dimensional structure of an intact human immunoglobulin.
Silverton, E. W., Navia, M. A., & Davies, D. R. (1977) · Proceedings of the National Academy of Sciences · doi:10.1073/pnas.74.11.5140 · Cited by 375
Self-citationLength distribution of CDRH3 in antibodies
Wu, T. T., Johnson, G., & Kabat, E. A. (1993) · Proteins: Structure, Function, and Bioinformatics · doi:10.1002/prot.340160102 · Cited by 284
The rate-limiting steps for the folding of an antibody scFv fragment
Jäger, M., & Plückthun, A. (1997) · FEBS Letters · doi:10.1016/s0014-5793(97)01350-1 · Cited by 44
Metadata
- Authors
- Segal, D. M., Padlan, E. A., Cohen, G. H., Rudikoff, S., Potter, M., & Davies, D. R.
- Venue
- Proceedings of the National Academy of Sciences
- Published
- 1974-11
- Volume
- 71
- Issue
- 11
- Pages
- 4298-4302
- ISSN
- 0027-8424 (ISSN-L)
- 1091-6490
- OpenAlex
- W2009444140
- Cited by
- 466
- References
- 1
- FWCI
- 35.51
- Type
- journal article
- Language
- en
- Open access
- green
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- CoChat. (2026). Citation check: The Three-Dimensional Structure of a Phosphorylcholine-Binding Mouse Immunoglobulin Fab and the Nature of the Antigen Binding Site. https://app.cochat.ai/papers/10.1073/pnas.71.11.4298
- The paper
- Segal, D. M., Padlan, E. A., Cohen, G. H., Rudikoff, S., Potter, M., & Davies, D. R. (1974). The Three-Dimensional Structure of a Phosphorylcholine-Binding Mouse Immunoglobulin Fab and the Nature of the Antigen Binding Site. Proceedings of the National Academy of Sciences. https://doi.org/10.1073/pnas.71.11.4298
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Bibliographic data: Semantic Scholar, OpenAlex, Crossref.
Contains information from the Semantic Scholar Academic Graph Datasets, made available under the ODC Attribution License (ODC-BY 1.0).
Semantic Scholar’s data is described in: Kinney, R., et al. (2023). The Semantic Scholar Open Data Platform. arXiv:2301.10140.
