The DOI matches its Crossref record; 11 of the 11 references it cites were found in a registry or an index.
Three-dimensional structure of an intact human immunoglobulin.
Open accessAbstract
We have examined the low-resolution structure of a complete human IgG1 using known domain coordinates from crystallographic investigations of immunoglobulin fragment structures. Our results indicate that the Fc portion of this molecule has a structure similar to that of an isolated Fc fragment, with the carbohydrate moiety playing a central role as the principal contact between the CH2 domains. Carbohydrate also forms a large part of the interface between the Fc and Fab regions. The relative orientations of the variable and constant portions of the Fab regions are intermediate between those reported previously, emphasizing the flexibility of the switch region. These data do not support a two-state allosteric model such as has been proposed for antibody effector functions.
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Citations
Cites
Three-Dimensional Structure of Immunoglobulins
Amzel, L. M., & Poljak, R. J. (1979) · Annual Review of Biochemistry · doi:10.1146/annurev.bi.48.070179.004525 · Cited by 692
Segal, D. M., Padlan, E. A., Cohen, G. H., Rudikoff, S., Potter, M., & Davies, D. R. (1974) · Proceedings of the National Academy of Sciences · doi:10.1073/pnas.71.11.4298 · Cited by 466
Self-citationCrystallographic structure studies of an IgG molecule and an Fc fragment
Huber, R., Deisenhofer, J., Colman, P. M., Matsushima, M., & Palm, W. (1976) · Nature · doi:10.1038/264415a0 · Cited by 422
Three-Dimensional Structure of the Fab′ Fragment of a Human Immunoglobulin at 2.8-Å Resolution
Poljak, R. J., Amzel, L. M., Avey, H. P., Chen, B. L., Phizackerley, R. P., & Saul, F. (1973) · Proceedings of the National Academy of Sciences · doi:10.1073/pnas.70.12.3305 · Cited by 384
Structure of a λ-type Bence-Jones protein at 3.5-Å resolution
Schiffer, M., Girling, R. L., Ely, K. R., & Edmundson, A. B. (1973) · Biochemistry · doi:10.1021/bi00747a013 · Cited by 355
The Structure of the Glycopeptide of Human γG Myeloma Proteins
Kornfeld, R., Keller, J., Baenziger, J., & Kornfeld, S. (1971) · Journal of Biological Chemistry · doi:10.1016/s0021-9258(18)62222-7 · Cited by 247
Epp, O., Colman, P., Fehlhammer, H., Bode, W., Huber, R., Schiffer, M., & Palm, W. (1974) · European Journal of Biochemistry · doi:10.1111/j.1432-1033.1974.tb03576.x · Cited by 227
Deisenhofer, J., Colman, P. M., Epp, O., & Huber, R. (1976) · Hoppe-Seyler´s Zeitschrift für physiologische Chemie · doi:10.1515/bchm2.1976.357.2.1421 · Cited by 123
Variability of three-dimensional structure in immunoglobulins.
PADLAN, E. A., & Davies, D. R. (1975) · Proceedings of the National Academy of Sciences · doi:10.1073/pnas.72.3.819 · Cited by 56
Self-citationThe structure determination of the variable portion of the Bence-Jones protein Au
Fehlhammer, H., Schiffer, M., Epp, O., Colman, P. M., Lattman, E. E., Schwager, P., Steigemann, W., & Schramm, H. J. (1975) · European Biophysics Journal · doi:10.1007/bf00539775 · Cited by 56
Cited by
The Anatomy and Taxonomy of Protein Structure
Richardson, J. S. (1981) · Advances in Protein Chemistry · doi:10.1016/s0065-3233(08)60520-3 · Cited by 3,375
Computational tools for aiding rational antibody design
Krawczyk, K., Dunbar, J., & Deane, C. M. (2017) · Methods in molecular biology · doi:10.1007/978-1-4939-6637-0_21 · Cited by 26
Metadata
- Authors
- Silverton, E. W., Navia, M. A., & Davies, D. R.
- Venue
- Proceedings of the National Academy of Sciences
- Published
- 1977-11
- Volume
- 74
- Issue
- 11
- Pages
- 5140-5144
- ISSN
- 0027-8424 (ISSN-L)
- 1091-6490
- OpenAlex
- W2061971053
- Cited by
- 375
- References
- 11
- FWCI
- 14.72
- Type
- journal article
- Language
- en
- Open access
- green
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- Silverton, E. W., Navia, M. A., & Davies, D. R. (1977). Three-dimensional structure of an intact human immunoglobulin. Proceedings of the National Academy of Sciences. https://doi.org/10.1073/pnas.74.11.5140
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Bibliographic data: Semantic Scholar, OpenAlex, Crossref.
Contains information from the Semantic Scholar Academic Graph Datasets, made available under the ODC Attribution License (ODC-BY 1.0).
Semantic Scholar’s data is described in: Kinney, R., et al. (2023). The Semantic Scholar Open Data Platform. arXiv:2301.10140.
