The DOI matches its Crossref record; 26 of the 26 references it cites were found in a registry or an index.
Gamma-Aminobutyric Acid Binding to Receptor Sites in the Rat Central Nervous System
Open accessAbstract
[ 3 H]Gamma-aminobutyric acid (GABA) binds to synaptic membrane fractions of rat brain in a selective fashion representing an interaction with postsynaptic GABA receptors. Inhibition of [ 3 H]GABA binding by a variety of amino acids closely parallels their ability to mimic the synaptic inhibitory actions of GABA and does not correlate with their relative affinity for the presynaptic synaptosomal GABA uptake system. [ 3 H]GABA binding is saturable with an affinity constant of about 0.1 μM. The GABA antagonist bicuculline inhibits [ 3 H]GABA binding with half maximal effects at 5 μM, whereas it requires a concentration of 0.5 mM to reduce synaptosomal GABA uptake by 50%. In subcellular fractionation experiments [ 3 H]GABA binding is most enriched in crude synaptic membranes. [ 3 H]GABA binding is greatest in the cerebellum, least in the spinal cord and medulla oblongatapons, with intermediate values in the thalamus, hippocampus, hypothalamus, cerebral cortex, midbrain, and corpus striatum.
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Cites
PROTEIN MEASUREMENT WITH THE FOLIN PHENOL REAGENT
Lowry, O., Rosebrough, N., Farr, A. L., & Randall, R. (1951) · Journal of Biological Chemistry · doi:10.1016/s0021-9258(19)52451-6 · Cited by 317,331
Glowinski, J., & Iversen, L. L. (1966) · Journal of Neurochemistry · doi:10.1111/j.1471-4159.1966.tb09873.x · Cited by 5,406
Handbook of Neurochemistry: Volume II: Structural Neurochemistry
(1969) · Springer eBooks · doi:10.1007/978-1-4899-7321-4 · Cited by 942
THE EXCITATION AND DEPRESSION OF SPINAL NEURONES BY STRUCTURALLY RELATED AMINO ACIDS
Curtis, D. R., & Watkins, J. C. (1960) · Journal of Neurochemistry · doi:10.1111/j.1471-4159.1960.tb13458.x · Cited by 856
Bicuculline, an antagonist of GABA and synaptic inhibition in the spinal cord of the cat
Curtis, D. R., Duggan, A. W., Felix, D., & Johnston, G. A. R. (1971) · Brain Research · doi:10.1016/0006-8993(71)90156-9 · Cited by 684
THE UPTAKE OF [3H]GABA BY SLICES OF RAT CEREBRAL CORTEX
Iversen, L. L., & Neal, M. J. (1968) · Journal of Neurochemistry · doi:10.1111/j.1471-4159.1968.tb06831.x · Cited by 541
A pharmacological study of the depression of spinal neurones by glycine and related amino acids
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Logan, W. J., & Snyder, S. H. (1972) · Brain Research · doi:10.1016/0006-8993(72)90540-9 · Cited by 476
Self-citationGlial Cell Function: Uptake of Transmitter Substances
Henn, F. A., & Hamberger, A. (1971) · Proceedings of the National Academy of Sciences · doi:10.1073/pnas.68.11.2686 · Cited by 459
Inhibitory of glycine on spinal neurons in the cat.
Werman, R., Davidoff, R. A., & Aprison, M. H. (1968) · Journal of Neurophysiology · doi:10.1152/jn.1968.31.1.81 · Cited by 416
Cited by
GABA‐Benzodiazepine‐Barbiturate Receptor Interactions
Olsen, R. W. (1981) · Journal of Neurochemistry · doi:10.1111/j.1471-4159.1981.tb05284.x · Cited by 894
Active transport of gamma-aminobutyric acid and glycine into synaptic vesicles
Kish, P. E., Fischer-Bovenkerk, C., & Ueda, T. (1989) · Proceedings of the National Academy of Sciences · doi:10.1073/pnas.86.10.3877 · Cited by 119
Metadata
- Authors
- zukin, S. R., Young, A. B., & Snyder, S. H.
- Venue
- Proceedings of the National Academy of Sciences
- Published
- 1974-12
- Volume
- 71
- Issue
- 12
- Pages
- 4802-4807
- ISSN
- 0027-8424 (ISSN-L)
- 1091-6490
- OpenAlex
- W2027861706
- Cited by
- 580
- References
- 26
- FWCI
- 7.10
- Type
- journal article
- Language
- en
- Open access
- bronze
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- zukin, S. R., Young, A. B., & Snyder, S. H. (1974). Gamma-Aminobutyric Acid Binding to Receptor Sites in the Rat Central Nervous System. Proceedings of the National Academy of Sciences. https://doi.org/10.1073/pnas.71.12.4802
Data sources
Bibliographic data: Semantic Scholar, OpenAlex, Crossref.
Contains information from the Semantic Scholar Academic Graph Datasets, made available under the ODC Attribution License (ODC-BY 1.0).
Semantic Scholar’s data is described in: Kinney, R., et al. (2023). The Semantic Scholar Open Data Platform. arXiv:2301.10140.
