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Muscarinic Cholinergic Binding in Rat Brain
Open accessAbstract
Binding sites with high affinity and specificity for [ 3 H]quinuclidinyl benzilate (QNB) are present in homogenates of rat brain. The characteristics of the binding sites resemble those of muscarinic cholinergic receptors. Specific binding is saturable with respect to [ 3 H]QNB and tissue concentration and is time-, temperature-, and pH-dependent. The bimolecular rate of association (2.0 × 10 8 M -1 min -1 ) and dissociation (1.2 × 10 -2 min -1 ) at 35° indicate a dissociation constant of 60 pM and a density of 65 pmol/g of brain. Muscarinic antagonists and agonists displace specific [ 3 H]QNB binding, while nicotinic and non-cholinergic drugs possess little affinity for [ 3 H]QNB-binding sites.
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Cited by
Graybiel, A. M., & Ragsdale, C. W. (1978) · Proceedings of the National Academy of Sciences · doi:10.1073/pnas.75.11.5723 · Cited by 784
CLAYTON, R. N., & CATT, K. J. (1981) · Endocrine Reviews · doi:10.1210/edrv-2-2-186 · Cited by 522
Nicotinic Cholinergic Receptor Binding Sites in the Brain: Regulation in Vivo
Schwartz, R. D., & Kellar, K. J. (1983) · Science · doi:10.1126/science.6828889 · Cited by 479
Ibotenic acid-induced neuronal degeneration: A morphological and neurochemical study
Schwarcz, R., H�kfelt, T., Fuxe, K., Jonsson, G., Goldstein, M., & Terenius, L. (1979) · Experimental Brain Research · doi:10.1007/bf00237708 · Cited by 462
Ishibashi, T., Horisawa, T., Tokuda, K., Ishiyama, T., Ogasa, M., Tagashira, R., Matsumoto, K., Nishikawa, H., Ueda, Y., Toma, S., et al. (2010) · The Journal of Pharmacology and Experimental Therapeutics · doi:10.1124/jpet.110.167346 · Cited by 438
Metadata
- Authors
- Yamamura, H. I., & Snyder, S. H.
- Venue
- Proceedings of the National Academy of Sciences
- Published
- 1974-05
- Volume
- 71
- Issue
- 5
- Pages
- 1725-1729
- ISSN
- 0027-8424 (ISSN-L)
- 1091-6490
- OpenAlex
- W2115250531
- Cited by
- 1,203
- References
- 0
- FWCI
- 13.80
- Type
- journal article
- Language
- en
- Open access
- green
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Contains information from the Semantic Scholar Academic Graph Datasets, made available under the ODC Attribution License (ODC-BY 1.0).
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