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Collagenase Production by Endotoxin-Activated Macrophages
Open accessAbstract
Peritoneal exudate macrophages, when exposed to bacterial lipopolysaccharide in culture, were found to produce collagenase (EC 3.4.24.3). This enzyme was not detected in extracts of the macrophages or in media from nonstimulated macrophage cultures. Lipidcontaining fractions of the lipopolysaccharide, including a glycolipid from the rough mutant of Salmonella minnesota (R595) and lipid A, were potent stimulators of collagenase production. The lipid-free polysaccharide fraction had no effect. Cycloheximide prevented the production of collagenase by endotoxin-treated macrophages, suggesting that it was newly synthesized.
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Citations
Cited by
Secretory products of macrophages.
Nathan, C. F. (1987) · Journal of Clinical Investigation · doi:10.1172/jci112815 · Cited by 2,615
Wound Healing Alterations Caused by Infection
Robson, M. C., Stenberg, B. D., & Heggers, J. P. (1990) · Clinics in Plastic Surgery · doi:10.1016/s0094-1298(20)30623-4 · Cited by 266
Regulation of immunity and inflammation by mediators from macrophages.
(1976) · PubMed Central · Cited by 92
Metadata
- Authors
- Wahl, L. M., Wahl, S. M., Mergenhagen, S. E., & Martin, G. R.
- Venue
- Proceedings of the National Academy of Sciences
- Published
- 1974-09
- Volume
- 71
- Issue
- 9
- Pages
- 3598-3601
- ISSN
- 0027-8424 (ISSN-L)
- 1091-6490
- OpenAlex
- W1988513287
- Cited by
- 300
- References
- 0
- FWCI
- 7.12
- Type
- journal article
- Language
- en
- Open access
- green
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- CoChat. (2026). Citation check: Collagenase Production by Endotoxin-Activated Macrophages. https://app.cochat.ai/papers/10.1073/pnas.71.9.3598
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- Wahl, L. M., Wahl, S. M., Mergenhagen, S. E., & Martin, G. R. (1974). Collagenase Production by Endotoxin-Activated Macrophages. Proceedings of the National Academy of Sciences. https://doi.org/10.1073/pnas.71.9.3598
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Bibliographic data: Semantic Scholar, OpenAlex, Crossref.
Contains information from the Semantic Scholar Academic Graph Datasets, made available under the ODC Attribution License (ODC-BY 1.0).
Semantic Scholar’s data is described in: Kinney, R., et al. (2023). The Semantic Scholar Open Data Platform. arXiv:2301.10140.
