Wound Healing Alterations Caused by Infection
Abstract
The theoretical alterations of wound healing caused by infection apply to the clinical situation. The level of bacteria is clinically important as are the specific qualities of a given species. This latter consideration has not been as completely studied as have the quantitative aspects. However, as pharmacologic means of overcoming the wound healing alterations are sought, specific bacterial species' idiosyncrasies will have to be examined. This has already been identified for the beta-hemolytic streptococcus. That species has not adhered to the level of greater than 10(5) organisms to produce wound complications. It has been repeatedly shown to cause wound problems at a much lower inoculum. Similar information may become available for other organisms. However, it is clear that because wound healing in the clinical situation occurs in the presence of bacteria, it is important to be aware of potential alterations in the repair process that these bacteria can cause.
Integrity signals
Registry
Cites
Statistics
Claims the paper makes
Claims other papers make about this one
Each is checked against this paper’s own text: does it say what the citing paper says it does?
In the inflammation phase, infection increases consumption of complement proteins, leading to decreased chemotaxis.
“In the inflammation phase, infection increases consumption of complement proteins, leading to decreased chemotaxis [251].”
From Transition from inflammation to proliferation: a critical step during wound healing (2016) · cites this paper as [251]
Infection suppresses fibroblast proliferation and causes disorganized collagen production, leading to decreased wound strength.
“Infection also suppresses proliferation of fibroblasts and causes disorganized collagen production, which lead to decreased wound strength [251].”
From Transition from inflammation to proliferation: a critical step during wound healing (2016) · cites this paper as [251]
Bacterial endotoxins induce prolonged elevation of proinflammatory cytokines, which increase MMP levels and decrease growth factor production.
“Moreover, bacterial endotoxins induce prolonged elevation of proinflammatory cytokines, e.g., IL-1β and TNF-α, which in turn increase MMP levels and decrease production of growth factors [251].”
From Transition from inflammation to proliferation: a critical step during wound healing (2016) · cites this paper as [251]
Cites
The physiology of wound healing
Hunt, T. K. (1988) · Annals of Emergency Medicine · doi:10.1016/s0196-0644(88)80351-2 · Cited by 457 · see citing works
STUDIES ON INFLAMMATION. III. GROWING CAPILLARIES: THEIR STRUCTURE AND PERMEABILITY.
Schoefl, G. I. (1963) · PubMed · Cited by 432 · see citing works
Schoefl, G. I. (1963) · Archiv für Pathologische Anatomie und Physiologie und für Klinische Medicin · doi:10.1007/bf00963592 · Cited by 312 · see citing works
Hunt, T. K., Knighton, D. R., Thakral, K. K., Goodson, W. H., & Andrews, W. S. (1984) · PubMed · Cited by 311 · see citing works
Collagenase Production by Endotoxin-Activated Macrophages
Wahl, L. M., Wahl, S. M., Mergenhagen, S. E., & Martin, G. R. (1974) · Proceedings of the National Academy of Sciences · doi:10.1073/pnas.71.9.3598 · Cited by 300 · see citing works
Activation of the Properdin Pathway of Complement in Patients with Gram-Negative Bacteremia
Fearon, D. T., Ruddy, S., Schur, P. H., & McCabe, W. R. (1975) · New England Journal of Medicine · doi:10.1056/nejm197505012921802 · Cited by 230 · see citing works
The Effect of Human Amniotic Membranes on the Bacterial Population of Infected Rat Burns
Robson, M. C., & KRIZEK, T.-J. (1973) · Annals of Surgery · doi:10.1097/00000658-197302000-00003 · Cited by 155 · see citing works
Self-citationRh, B., NUCCIO, P. A., Wolfe, E. T., COLLINS, B., Tamburro, C., Glass, W., & Cm, M. (1964) · PubMed · Cited by 147 · see citing works
Functional Characteristics of Human Toxic Neutrophils
McCall, C. E., Caves, J., Cooper, R., & DeChatelet, L. (1971) · The Journal of Infectious Diseases · doi:10.1093/infdis/124.1.68 · Cited by 136 · see citing works
Robson, M. C., Krizek, T. J., & Heggers, J. P. (1973) · Current Problems in Surgery · doi:10.1016/s0011-3840(73)80010-3 · Cited by 132 · see citing works
Self-citationCarrel, A., & Hartmann, A. (1916) · The Journal of Experimental Medicine · doi:10.1084/jem.24.5.429 · Cited by 129 · see citing works
Solomkin, J. S., Jenkins, M. K., Nelson, R. D., Chenoweth, D. E., & Simmons, R. L. (1981) · PubMed · Cited by 129 · see citing works
Chemiluminescence by Polymorphonuclear Leukocytes from Patients with Active Bacterial Infection
Barbour, A. G., Allred, C., SOLBERG, C. O., & Hill, H. R. (1980) · The Journal of Infectious Diseases · doi:10.1093/infdis/141.1.14 · Cited by 125 · see citing works
The effect of local infection upon wound healing: An experimental study
Bucknall, T. E. (1980) · British journal of surgery · doi:10.1002/bjs.1800671205 · Cited by 123 · see citing works
Quantitative bacteriology and delayed wound closure.
Robson, M. C., Lea, C. E., Dalton, J. B., & Heggers, J. P. (1968) · PubMed · Cited by 115 · see citing works
Self-citationA comparison of shock due to endotoxin with anaphylactic shock.
Mh, W., & Ww, S. (1957) · PubMed · Cited by 109 · see citing works
Hyperactivity of Neutrophil Leukotactic Responses during Active Bacterial Infection
Hill, H. R., Gerrard, J. M., Hogan, N. A., & Quie, P. G. (1974) · Journal of Clinical Investigation · doi:10.1172/jci107666 · Cited by 105 · see citing works
The efficacy of systemic antibiotics in the treatment of granulating wounds
Robson, M. C., Edstrom, L. E., Krizek, T. J., & Groskin, M. G. (1974) · Journal of Surgical Research · doi:10.1016/0022-4804(74)90046-8 · Cited by 103 · see citing works
Self-citationCurrent concepts and approaches to wound healing
Orgill, D. P., & Demling, R. H. (1988) · Critical Care Medicine · doi:10.1097/00003246-198809000-00016 · Cited by 97 · see citing works
Immediate Effects of Intravenous Endotoxin on Serotonin Concentrations and Blood Platelets
Davis, R. B., Meeker, W. R., & McQuarrie, D. G. (1960) · Circulation Research · doi:10.1161/01.res.8.1.234 · Cited by 89 · see citing works
THE RELATIONSHIP BETWEEN GRANULATION TISSUE, BACTERIA, AND SKIN GRAFTS IN BURNED PATIENTS
Eade, G. G. (1958) · Plastic & Reconstructive Surgery · doi:10.1097/00006534-195807000-00004 · Cited by 86 · see citing works
The effect of microbial contamination on musculocutaneous and random flaps
Murphy, R. C., Robson, M. C., Heggers, J. P., & Kadowaki, M. H. (1986) · Journal of Surgical Research · doi:10.1016/0022-4804(86)90011-9 · Cited by 75 · see citing works
Self-citationCarrel, A. (1921) · The Journal of Experimental Medicine · doi:10.1084/jem.34.5.425 · Cited by 67 · see citing works
Infection in the Surgical Patient: An Imbalance in the Normal Equilibrium
Robson, M. C. (1979) · Clinics in Plastic Surgery · doi:10.1016/s0094-1298(20)32011-3 · Cited by 67 · see citing works
Self-citationRobson, M. C. (1988) · Annals of Emergency Medicine · doi:10.1016/s0196-0644(88)80352-4 · Cited by 64 · see citing works
Self-citationRespiratory Gas Tensions and Collagen in Infected Wounds
Niinikoski, J., GRISLIS, G., & Hunt, T. K. (1972) · Annals of Surgery · doi:10.1097/00000658-197204000-00020 · Cited by 64 · see citing works
Neutrophils Dysfunction During the Course of Intra-abdominal Infection
Solomkin, J. S., BAUMAN, M. P., Nelson, R. D., & Simmons, R. L. (1981) · Annals of Surgery · doi:10.1097/00000658-198107000-00003 · Cited by 60 · see citing works
Inflammatory Reaction and Blood Flow in Experimental Wounds Inoculated with Staphylococcus aureus
Laato, M. K., Niinikoski, J., Lundberg, C., & Gerdin, B. (2008) · European Surgical Research · doi:10.1159/000128738 · Cited by 60 · see citing works
The role of infection on wound healing.
Haan, B. B. D., Ellis, H., & Wilks, M. (1974) · PubMed · Cited by 59 · see citing works
Al-Himdani, S., & Ardeshir, B. (2018) · CRC Press eBooks · doi:10.1201/9780203731031-10 · Cited by 59 · see citing works
The Effect of Bacteria on the Take of Split-Thickness Skin Grafts in Rabbits
Liedberg, N. C. F., Reiss, E., Artz, C. P., & Brame, R. E. (1955) · Annals of Surgery · doi:10.1097/00000658-195507000-00011 · Cited by 57 · see citing works
The Reclosure of Postoperative Incisional Abscesses Based on Bacterial Quantification of the Wound
Robson, M. C., Shaw, R. C., & Heggers, J. P. (1970) · Annals of Surgery · doi:10.1097/00000658-197002000-00017 · Cited by 55 · see citing works
Self-citationA quantitative study of impaired healing resulting from infection.
Smith, M., & Enquist, I. F. (1967) · PubMed · Cited by 46 · see citing works
Accelerated healing in infected wounds.
Tenorio, A., Jindrák, K., Weiner, M., Bella, E. D., & Enquist, I. F. (1976) · PubMed · Cited by 46 · see citing works
Traumatic injury. Infection and other Immunologic sequelae
Levick, P. L. (1984) · Burns · doi:10.1016/0305-4179(84)90017-2 · Cited by 45 · see citing works
Robson, M. C., & Heggers, J. P. (1969) · Journal of Surgical Research · doi:10.1016/0022-4804(69)90068-7 · Cited by 41 · see citing works
Self-citationDunphy, J. E. (1970) · The American Journal of Surgery · doi:10.1016/0002-9610(70)90002-4 · Cited by 39 · see citing works
Dudgeon, L. S., & Goadby, H. K. (1931) · Journal of Hygiene · doi:10.1017/s0022172400010792 · Cited by 28 · see citing works
Complement activation early in endotoxin shock
Heideman, M., KAIJSER, B., & Gelin, L. E. (1979) · Journal of Surgical Research · doi:10.1016/0022-4804(79)90080-5 · Cited by 25 · see citing works
Lawrence, J. C. (1987) · Burns · doi:10.1016/0305-4179(87)90086-6 · Cited by 23 · see citing works
Granulation tissue formation in experimental wounds inoculated with Staphylococcus aureus.
Laato, M. K., Lehtonen, O. P., & Niinikoski, J. (1985) · PubMed · Cited by 21 · see citing works
A NEW MODEL FOR THE STUDY OF WOUND INFECTION
Hunt, T. K., Jawetz, E., Hutchison, J. G. P., & Dunphy, J. E. (1967) · The Journal of Trauma: Injury, Infection, and Critical Care · doi:10.1097/00005373-196703000-00012 · Cited by 20 · see citing works
Prospective: a retrospective perspective on the nature of wounds.
Tk, H. (1988) · PubMed · Cited by 20 · see citing works
Studies in Wound Healing. III. Contraction in Vit. C Deficiency
Grillo, H. C., & Gross, J. (1959) · Experimental Biology and Medicine · doi:10.3181/00379727-101-24907 · Cited by 18 · see citing works
Caulfield, P. A., & Madigan, H. S. (1953) · The American Journal of Surgery · doi:10.1016/0002-9610(53)90400-0 · Cited by 16 · see citing works
Prostaglandin formation in bacteria
Gulbis, E., Marión, A., Dumont, J. E., & Schell-Frederick, E. (1979) · Prostaglandins · doi:10.1016/s0090-6980(79)80058-1 · Cited by 16 · see citing works
Sarnquist, F. H. (1983) · PubMed · Cited by 13 · see citing works
Principles of Basic Surgical Practice
Grant, C. S. (1987) · Mayo Clinic Proceedings · doi:10.1016/s0025-6196(12)65062-9 · Cited by 10 · see citing works
Woodward, E. R. (1989) · JAMA · doi:10.1001/jama.1989.03420240136047 · Cited by 8 · see citing works
Effect of bFGF on the inhibition of contraction caused by bacterial contamination
Stenberg, B. D., Phillips, L., Hokanson, J., Heggers, J. P., & Robson, M. C. (1989) · Surgical forum · Cited by 6 · see citing works
Self-citationPrevention of micro abscess formation following thermal injury
London, M. D. (1982) · Cited by 3 · see citing works
Krizek, T. J., & Robson, M. C. (1979) · Clinics in Plastic Surgery · doi:10.1016/s0094-1298(20)32010-1 · Cited by 3 · see citing works
Self-citation
Flagged first, then by citations
2 of the 54 references couldn’t be matched to a known paper.
Cited by
Sorted by citations
Transition from inflammation to proliferation: a critical step during wound healing
Landén, N. X., Li, D., & Ståhle, M. (2016) · Cellular and Molecular Life Sciences · doi:10.1007/s00018-016-2268-0 · Cited by 1,980 · see citing works
Edwards, R., & Harding, K. G. (2004) · Current Opinion in Infectious Diseases · doi:10.1097/00001432-200404000-00004 · Cited by 1,099 · see citing works
Physiology and healing dynamics of chronic cutaneous wounds
Stadelmann, W. K., Digenis, A. G., & Tobin, G. R. (1998) · The American Journal of Surgery · doi:10.1016/s0002-9610(98)00183-4 · Cited by 910 · see citing works
Diabetic Foot Disorders: A Clinical Practice Guideline (2006 Revision)
Frykberg, R. G., Zgonis, T., Armstrong, D. G., Driver, V. R., Giurini, J. M., Kravitz, S. R., Landsman, A. S., Lavery, L. A., Moore, J. C., Schuberth, J. M., et al. (2006) · The Journal of Foot & Ankle Surgery · doi:10.1016/s1067-2516(07)60001-5 · Cited by 844 · see citing works
Katti, D. S., Robinson, K. W., Ko, F., & Laurencin, C. T. (2004) · Journal of Biomedical Materials Research Part B Applied Biomaterials · doi:10.1002/jbm.b.30041 · Cited by 695 · see citing works
Fonder, M. A., Lazarus, G. S., Cowan, D. A., Aronson-Cook, B., Kohli, A. R., & Mamelak, A. J. (2008) · Journal of the American Academy of Dermatology · doi:10.1016/j.jaad.2007.08.048 · Cited by 665 · see citing works
Robson, M. C. (1997) · Surgical Clinics of North America · doi:10.1016/s0039-6109(05)70572-7 · Cited by 643 · see citing works
Self-citationWound healing: Biologic features and approaches to maximize healing trajectories
Robson, M. C., Steed, D. L., & Franz, M. (2001) · Current Problems in Surgery · doi:10.1067/msg.2001.111167 · Cited by 504 · see citing works
Self-citationObesity and Surgical Wound Healing: A Current Review
Pierpont, Y. N., Dinh, T. P., Salas, R., Johnson, E. L., Wright, T. G., Robson, M. C., & Payne, W. G. (2014) · ISRN Obesity · doi:10.1155/2014/638936 · Cited by 462 · see citing works
Self-citationComparative evaluation of silver‐containing antimicrobial dressings and drugs
Castellano, J. J., Shafii, S. M., Ko, F., Donate, G., Wright, T. E., Mannari, R. J., Payne, W. G., Smith, D. J., & Robson, M. C. (2007) · International Wound Journal · doi:10.1111/j.1742-481x.2007.00316.x · Cited by 434 · see citing works
Self-citationThe validity of the clinical signs and symptoms used to identify localized chronic wound infection
Gardner, S. E., Frantz, R. A., & Doebbeling, B. N. (2001) · Wound Repair and Regeneration · doi:10.1046/j.1524-475x.2001.00178.x · Cited by 415 · see citing works
Mechanisms and Clinical Applications of the Vacuum-Assisted Closure (VAC) Device
Venturi, M. L., Attinger, C. E., Mesbahi, A. N., Hess, C. L., & Graw, K. S. (2005) · American Journal of Clinical Dermatology · doi:10.2165/00128071-200506030-00005 · Cited by 374 · see citing works
Stadelmann, W. K., Digenis, A. G., & Tobin, G. R. (1998) · The American Journal of Surgery · doi:10.1016/s0002-9610(98)00184-6 · Cited by 319 · see citing works
Guidelines for the treatment of diabetic ulcers
Steed, D. L., Attinger, C. E., Colaizzi, T., Crossland, M. C., Franz, M., Harkless, L. B., Johnson, A., Moosa, H. H., Robson, M. C., Serena, T. E., et al. (2006) · Wound Repair and Regeneration · doi:10.1111/j.1524-475x.2006.00176.x · Cited by 309 · see citing works
Self-citationAttinger, C. E., Janis, J. E., Steinberg, J. S., Schwartz, J. S., Alattar, A. A., & Couch, K. S. (2006) · Plastic & Reconstructive Surgery · doi:10.1097/01.prs.0000225470.42514.8f · Cited by 294 · see citing works
Guidelines for the treatment of pressure ulcers
Whitney, J., Phillips, L. G., Aslam, R. S., Barbul, A., Gottrup, F., Gould, L. J., Robson, M. C., Rodeheaver, G. T., Thomas, D. R., & Stotts, N. A. (2006) · Wound Repair and Regeneration · doi:10.1111/j.1524-475x.2006.00175.x · Cited by 292 · see citing works
Self-citationZhao, G., Hochwalt, P. C., Usui, M. L., Underwood, R. A., Singh, P. K., James, G. A., Stewart, P. S., Fleckman, P., & Olerud, J. E. (2010) · Wound Repair and Regeneration · doi:10.1111/j.1524-475x.2010.00608.x · Cited by 275 · see citing works
An Algorithm for Abdominal Wall Reconstruction
Rohrich, R. J., Lowe, J. B., Hackney, F. L., Bowman, J. L., & Hobar, P. C. (2000) · Plastic & Reconstructive Surgery · doi:10.1097/00006534-200001000-00036 · Cited by 233 · see citing works
Cellular events and biomarkers of wound healing
Yussof, S. J. M., Omar, E., Pai, D. R., & Sood, S. (2012) · Indian Journal of Plastic Surgery · doi:10.4103/0970-0358.101282 · Cited by 218 · see citing works
The chronic wound: impaired healing and solutions in the context of wound bed preparation
Falanga, V. (2003) · Blood Cells Molecules and Diseases · doi:10.1016/j.bcmd.2003.09.020 · Cited by 207 · see citing works
Wound Healing: Part I. Basic Science
Janis, J. E., & Harrison, B. L. (2016) · Plastic & Reconstructive Surgery · doi:10.1097/prs.0000000000002773 · Cited by 204 · see citing works
The future of recombinant growth factors in wound healing
Robson, M. C., Mustoe, T. A., & Hunt, T. K. (1998) · The American Journal of Surgery · doi:10.1016/s0002-9610(98)00186-x · Cited by 200 · see citing works
Self-citationGuidelines for the treatment of venous ulcers
Robson, M. C., Cooper, D. M., Aslam, R. S., Gould, L. J., Harding, K. G., Margolis, D. J., Ochs, D. E., Serena, T. E., Snyder, R., Steed, D. L., et al. (2006) · Wound Repair and Regeneration · doi:10.1111/j.1524-475x.2006.00174.x · Cited by 196 · see citing works
Self-citationQualitative bacteriology and leg ulcer healing
Trengove, N. J., Stacey, M. C., McGechie, D., Stingemore, N., & Mata, S. (1996) · Journal of Wound Care · doi:10.12968/jowc.1996.5.6.277 · Cited by 195 · see citing works
Mustoe, T. A. (1994) · Archives of Surgery · doi:10.1001/archsurg.1994.01420260109015 · Cited by 174 · see citing works
Karami, Z., Rezaeian, I., Zahedi, P., & Abdollahi, M. R. (2012) · Journal of Applied Polymer Science · doi:10.1002/app.38683 · Cited by 167 · see citing works
RetractedOptimizing Healing of the Acute Wound by Minimizing Complications
Franz, M., Steed, D. L., & Robson, M. C. (2007) · Current Problems in Surgery · doi:10.1067/j.cpsurg.2007.07.001 · Cited by 163 · see citing works
Self-citationFabian, T. S., Kaufman, H. J., Lett, E. D., Thomas, J. B., Rawl, D. K., Lewis, P. L., Summitt, J. B., Merryman, J. I., Schaeffer, D. O., Sargent, L. A., et al. (2000) · The American Surgeon · doi:10.1177/000313480006601209 · Cited by 147 · see citing works
Kwak, G., Cheng, J., Kim, H., Song, S., Lee, S.-J., Yang, Y., Jeong, J., Lee, J. E., Messersmith, P., & Kim, S. H. (2022) · Small · doi:10.1002/smll.202200060 · Cited by 131 · see citing works
Fernández‐Montequín, J. I., Valenzuela‐Silva, C., Díaz, O. M. G., Savigne, W., Sancho‐Soutelo, N., Rivero‐Fernández, F., Sánchez‐Penton, P., Morejón‐Vega, L., Artaza‐Sanz, H., García‐Herrera, A., et al. (2009) · International Wound Journal · doi:10.1111/j.1742-481x.2009.00641.x · Cited by 138 · see citing works
The role of skin substitutes in the management of chronic cutaneous wounds
Greaves, N. S., Iqbal, S. A., Baguneid, M. S., & Bayat, A. (2013) · Wound Repair and Regeneration · doi:10.1111/wrr.12029 · Cited by 135 · see citing works
Han, G., Martinez, L. R., Mihu, M., Friedman, A., Friedman, J., & Nosanchuk, J. (2009) · PLoS ONE · doi:10.1371/journal.pone.0007804 · Cited by 125 · see citing works
Nanozymes for Regenerative Medicine
Mou, X., Wu, Q., Zhang, Z., Liu, Y., Zhang, J., Zhang, C., Chen, X., Fan, K., & Liu, H. (2022) · Small Methods · doi:10.1002/smtd.202200997 · Cited by 128 · see citing works
Retardation of wound healing by silver sulfadiazine is reversed by Aloe vera and nystatin
Müller, M. J., Hollyoak, M. A., Moaveni, Z., Brown, T., Herndon, D. N., & Heggers, J. P. (2003) · Burns · doi:10.1016/s0305-4179(03)00198-0 · Cited by 122 · see citing works
Self-citationA review of wound healing and wound dressing products
Hanna, J. R., & Giacopelli, J. A. (1997) · The Journal of Foot & Ankle Surgery · doi:10.1016/s1067-2516(97)80003-8 · Cited by 118 · see citing works
Mihu, M., Sandkovsky, U., Han, G., Friedman, J., Nosanchuk, J., & Martinez, L. R. (2010) · Virulence · doi:10.4161/viru.1.2.10038 · Cited by 112 · see citing works
Holmes, C., Wrobel, J. S., Eachern, M. P. M., & Boles, B. R. (2013) · Diabetes Metabolic Syndrome and Obesity · doi:10.2147/dmso.s36024 · Cited by 115 · see citing works
Bacterial Biofilm: Its Composition, Formation and Role in Human Infections
Jamal, M., Tasneem, U., Hussain, T., & Andleeb, S. (2015) · Research and Reviews: Journal of Microbiology and Biotechnology · Cited by 115 · see citing works
Steed, D. L. (2004) · The American Journal of Surgery · doi:10.1016/s0002-9610(03)00307-6 · Cited by 113 · see citing works
Laryngotracheal Reconstruction in the Adult: A Ten Year Experience
Lano, C. F., Ossoff, R. H., Duncavage, J. A., Courey, M. S., Reinisch, L., & Netterville, J. L. (1998) · Annals of Otology Rhinology & Laryngology · doi:10.1177/000348949810700202 · Cited by 112 · see citing works
Biofilms and bacterial imbalances in chronic wounds: anti‐Koch
Percival, S. L., Thomas, J. G., & Williams, D. W. (2010) · International Wound Journal · doi:10.1111/j.1742-481x.2010.00668.x · Cited by 111 · see citing works
Cosmeceuticals and natural products: wound healing
Davis, S. C., & Perez, R. (2009) · Clinics in Dermatology · doi:10.1016/j.clindermatol.2009.05.015 · Cited by 108 · see citing works
Persistent wound infection delays epidermal maturation and increases scarring in thermal burns
Singer, A. J., & McClain, S. A. (2002) · Wound Repair and Regeneration · doi:10.1046/j.1524-475x.2002.10606.x · Cited by 104 · see citing works
Larijani, B. A., & Forouzandeh, F. (2003) · Iranian Journal of Diabetes and Metabolism · Cited by 102 · see citing works
Janis, J. E., & Harrison, B. L. (2014) · Plastic & Reconstructive Surgery · doi:10.1097/01.prs.0000437224.02985.f9 · Cited by 102 · see citing works
VenUS II: a randomised controlled trial of larval therapy in the management of leg ulcers
Dumville, J. C., Worthy, G., Soares, M. O., Bland, J., Cullum, N. A., Dowson, C. G., Iglesias, C., McCaughan, D., Mitchell, J., Nelson, E. A., et al. (2009) · Health Technology Assessment · doi:10.3310/hta13550 · Cited by 100 · see citing works
Wound Dressing Modifications for Accelerated Healing of Infected Wounds
Vivcharenko, V., Trzaskowska, M., & Przekora, A. (2023) · International Journal of Molecular Sciences · doi:10.3390/ijms24087193 · Cited by 99 · see citing works
Izadi, K., & Ganchi, P. A. (2005) · Clinics in Plastic Surgery · doi:10.1016/j.cps.2004.11.011 · Cited by 98 · see citing works
Fumal, I., Braham, C., Paquet, P., Piérard-Franchimont, C., & Piérard, G. E. (2002) · Dermatology · doi:10.1159/000057729 · Cited by 98 · see citing works
Attinger, C. E., & Bulan, E. J. (2001) · Foot and Ankle Clinics · doi:10.1016/s1083-7515(02)00010-4 · Cited by 91 · see citing works
Debridement: a vital component of wound bed preparation.
Kirshen, C., Woo, K. Y., Ayello, E., & Sibbald, R. (2006) · Advances in Skin & Wound Care · doi:10.1097/00129334-200611000-00011 · Cited by 101 · see citing works
Aerobic and anaerobic microbiology of chronic venous ulcers
Brook, I., & Frazier, E. H. (1998) · International Journal of Dermatology · doi:10.1046/j.1365-4362.1998.00445.x · Cited by 87 · see citing works
Stratford, A. F., Zoutman, D., & Davidson, J. S. (2002) · Plastic & Reconstructive Surgery · doi:10.1097/00006534-200210000-00010 · Cited by 86 · see citing works
Wounds: Biology, Pathology, and Management
Lorenz, H. P., & Longaker, M. T. (2008) · Springer eBooks · doi:10.1007/978-0-387-68113-9_10 · Cited by 84 · see citing works
An in Vivo Comparison of Topical Agents on Wound Repair
Bennett, L. L., Rosenblum, R. S., Perlov, C., Davidson, J. M., Barton, R. M., & Nanney, L. B. (2001) · Plastic & Reconstructive Surgery · doi:10.1097/00006534-200109010-00011 · Cited by 84 · see citing works
Could chronic wounds not heal due to too low local copper levels?
Borkow, G., Gabbay, J., & Zatcoff, R. C. (2008) · Medical Hypotheses · doi:10.1016/j.mehy.2007.06.006 · Cited by 81 · see citing works
What is the most effective way to reduce incidence of amputation in the diabetic foot?
Apelqvist, J., & Larsson, J. (2000) · Diabetes/Metabolism Research and Reviews · doi:10.1002/1520-7560(200009/10)16:1+ · Cited by 406 · see citing works
Fernández‐Montequín, J. I., Infante‐Cristiá, E., Valenzuela‐Silva, C., Franco‐Pérez, N., Savigne-Gutiérrez, W., Artaza‐Sanz, H., Morejón‐Vega, L., González‐Benavides, C., Eliseo‐Musenden, O., García‐Iglesias, E., et al. (2007) · International Wound Journal · doi:10.1111/j.1742-481x.2007.00344.x · Cited by 80 · see citing works
Efficacy of gaseous nitric oxide in the treatment of skin and soft tissue infections
Ghaffari, A., Jalili, R., Ghaffari, M., Miller, C. C., & Ghahary, A. (2007) · Wound Repair and Regeneration · doi:10.1111/j.1524-475x.2007.00239.x · Cited by 73 · see citing works
Quality Indicators for Prevention and Management of Pressure Ulcers in Vulnerable Elders
Bates‐Jensen, B. M. (2001) · Annals of Internal Medicine · doi:10.7326/0003-4819-135-8_part_2-200110161-00014 · Cited by 77 · see citing works
Foundations of good ulcer care
Steed, D. L. (1998) · The American Journal of Surgery · doi:10.1016/s0002-9610(98)00178-0 · Cited by 77 · see citing works
Oates, A., Bowling, F. L., Boulton, A. J. M., & McBain, A. J. (2012) · Journal of Clinical Microbiology · doi:10.1128/jcm.06599-11 · Cited by 74 · see citing works
Bishop, J. B., Phillips, L. G., Mustoe, T. A., VanderZee, A. J., Wiersema, L., Roach, D. E., Heggers, J. P., Hill, D. P., Taylor, E. L., & Robson, M. C. (1992) · Journal of Vascular Surgery · doi:10.1016/0741-5214(92)90115-o · Cited by 74 · see citing works
Self-citationVacuum‐assisted closure therapy in the management of head and neck wounds
Dhir, K., Reino, A. J., & Lipana, J. D. (2008) · The Laryngoscope · doi:10.1002/lary.20000 · Cited by 73 · see citing works
Management of chronic venous leg ulcers: A literature-guided approach
Margolis, D. J., & Cohen, J. H. (1994) · Clinics in Dermatology · doi:10.1016/0738-081x(94)90253-4 · Cited by 73 · see citing works
SOFT TISSUE RECONSTRUCTION FOR CALCANEAL FRACTURES OR OSTEOMYELITIS
Attinger, C. E., & Cooper, P. S. (2001) · Orthopedic Clinics of North America · doi:10.1016/s0030-5898(05)70199-1 · Cited by 73 · see citing works
Mota, F. A. R., Passos, M. L. C., Santos, J. L. M., & Saraiva, M. L. M. F. S. (2024) · Biosensors and Bioelectronics · doi:10.1016/j.bios.2024.116095 · Cited by 72 · see citing works
Frantz, F. W., Bettinger, D. A., Haynes, J. H., Johnson, D. E., Harvey, K. M., Dalton, H. P., Yager, D. R., Diegelmann, R. F., & Cohen, I. K. (1993) · Journal of Pediatric Surgery · doi:10.1016/0022-3468(93)90243-e · Cited by 72 · see citing works
Nitric Oxide Releasing Nanoparticles for Treatment of Candida Albicans Burn Infections
Macherla, C., Sanchez, D. A., Ahmadi, M. S., Vellozzi, E. M., Friedman, A. J., Nosanchuk, J. D., & Martinez, L. R. (2012) · Frontiers in Microbiology · doi:10.3389/fmicb.2012.00193 · Cited by 70 · see citing works
Hao, L., Wang, J., Zou, Z., Yan, G., Dong, S., Deng, J., Ran, X., Feng, Y., Luo, C., Wang, Y., et al. (2008) · Gene Therapy · doi:10.1038/gt.2008.133 · Cited by 68 · see citing works
Swab Versus Biopsy for the Diagnosis of Chronic Infected Wounds
Rondas, A., Schols, J. M. G. A., Halfens, R. J. G., & Stobberingh, E. E. (2013) · Advances in Skin & Wound Care · doi:10.1097/01.asw.0000428984.58483.aa · Cited by 68 · see citing works
Patel, P. V., Kumar, V., Kumar, S., Doddawad, V. G., & Patel, A. D. (2011) · Journal of Investigative and Clinical Dentistry · doi:10.1111/j.2041-1626.2011.00072.x · Cited by 66 · see citing works
Aramwit, P., Muangman, P., Namviriyachote, N., & Srichana, T. (2010) · International Journal of Molecular Sciences · doi:10.3390/ijms11082864 · Cited by 66 · see citing works
Surface bacteriology of venous leg ulcers and healing outcome
Moore, K., Hall, V., Paull, A., Morris, T., Brown, S. T., McCulloch, D., Richardson, M. C., & Harding, K. G. (2010) · Journal of Clinical Pathology · doi:10.1136/jcp.2010.077032 · Cited by 65 · see citing works
Potential role of anaerobic cocci in impaired human wound healing
Wall, I. B., Davies, C. E., Hill, K. E., Wilson, M. J., Stephens, P., Harding, K. G., & Thomas, D. W. (2002) · Wound Repair and Regeneration · doi:10.1046/j.1524-475x.2002.t01-1-10602.x · Cited by 62 · see citing works
Robson, M. C., Payne, W. G., Ko, F., Mentis, M., Donati, G., Shafii, S. M., Culverhouse, S., Wang, L., Khosrovi, B., Najafi, R., et al. (2007) · PubMed Central · Cited by 62 · see citing works
Self-citationOxidized Regenerated Cellulose/Collagen Dressings: Review of Evidence and Recommendations
Wu, S., Applewhite, A. J., Niezgoda, J., Snyder, R., Shah, J. B., Cullen, B., Schultz, G. S., Harrison, J. E., Hill, R., Howell, M., et al. (2017) · Advances in Skin & Wound Care · doi:10.1097/01.asw.0000525951.20270.6c · Cited by 62 · see citing works
Silver‐based wound dressings reduce bacterial burden and promote wound healing
Lin, Y., Hsu, W.-S., Chung, W., Ko, T., & Lin, J. (2015) · International Wound Journal · doi:10.1111/iwj.12467 · Cited by 61 · see citing works
Fibroblast growth factor reverses the bacterial retardation of wound contraction
Hayward, P. G., Hokanson, J., Heggers, J. P., Fiddes, J. C., Klingbeil, C., Goeger, M. P., & Robson, M. C. (1992) · The American Journal of Surgery · doi:10.1016/0002-9610(92)90004-b · Cited by 61 · see citing works
Self-citationCytokine manipulation of the wound
Robson, M. C. (2003) · Clinics in Plastic Surgery · doi:10.1016/s0094-1298(02)00073-1 · Cited by 59 · see citing works
Self-citationRondas, A., Schols, J. M. G. A., Stobberingh, E. E., & Halfens, R. J. G. (2013) · International Wound Journal · doi:10.1111/iwj.12172 · Cited by 58 · see citing works
Kozlovsky, A., Artzi, Z., Hirshberg, A., Israeli‐Tobias, C., & Reich, L. (2007) · Journal Of Clinical Periodontology · doi:10.1111/j.1600-051x.2006.01033.x · Cited by 57 · see citing works
Effects of granulocyte-macrophage colony-stimulating factor on wound contraction
Robson, M. C., Kucukcelebi, A., Carp, S. S., Hayward, P. G., Hui, P.-S., Cowan, W. T., Ko, F., & Cooper, D. M. (1994) · European Journal of Clinical Microbiology & Infectious Diseases · doi:10.1007/bf01973601 · Cited by 56 · see citing works
Self-citationINHIBITION OF WOUND CONTRACTION BY TOPICAL ANTIMICROBIALS
Leitch, I. O. W., Küçükçelebi, A., & Robson, M. C. (1993) · Australian and New Zealand Journal of Surgery · doi:10.1111/j.1445-2197.1993.tb00385.x · Cited by 55 · see citing works
Self-citationChronic Wound Colonization, Infection, and Biofilms
Kirketerp‐Møller, K., Zulkowski, K. M., & James, G. A. (2010) · Springer eBooks · doi:10.1007/978-1-4419-6084-9_2 · Cited by 53 · see citing works
Attinger, C. E., Bulan, E. J., & Blume, P. A. (2000) · Clinics in Podiatric Medicine and Surgery · doi:10.1016/s0891-8422(23)01152-7 · Cited by 53 · see citing works
Perceived risk factors for nonunion following foot and ankle arthrodesis
Thevendran, G., Shah, K., Pinney, S. J., & Younger, A. S. E. (2017) · Journal of orthopaedic surgery · doi:10.1177/2309499017692703 · Cited by 47 · see citing works
Snyder, R., Fife, C. E., & Moore, Z. E. H. (2016) · Advances in Skin & Wound Care · doi:10.1097/01.asw.0000482354.01988.b4 · Cited by 45 · see citing works
Vacuum-Assisted Closure for Defects of the Abdominal Wall
DeFranzo, A. J., Pitzer, K., Molnar, J. A., Marks, M. W., Chang, M., Miller, P. R., Letton, R. W., & Argenta, L. C. (2008) · Plastic & Reconstructive Surgery · doi:10.1097/01.prs.0000299268.51008.47 · Cited by 44 · see citing works
A review of studies that examine the impact of infection on the normal wound-healing process
Penhallow, K. (2005) · Journal of Wound Care · doi:10.12968/jowc.2005.14.3.26747 · Cited by 44 · see citing works
Robson, M. C. (2003) · Surgical Clinics of North America · doi:10.1016/s0039-6109(02)00197-4 · Cited by 44 · see citing works
Self-citationSaoud, T. M. A., Huang, G. T. ‐., Gibbs, J. L., Sigurðsson, Á., & Lin, L. M. (2015) · Journal of Endodontics · doi:10.1016/j.joen.2015.07.004 · Cited by 42 · see citing works
Kim, G., & Yoon, H. Y. (2007) · Applied Physics A · doi:10.1007/s00339-007-4330-0 · Cited by 42 · see citing works
Mohammadi, A. A., Jafari, S. M. S., Kiasat, M., Pakyari, M. R., & Ahrari, I. (2013) · Burns · doi:10.1016/j.burns.2013.01.019 · Cited by 40 · see citing works
Ruf, M., Sopoh, G. E., Brun, L. V. C., Dossou, A. D., Barogui, Y. T., Johnson, R. C., & Pluschke, G. (2011) · PLoS neglected tropical diseases · doi:10.1371/journal.pntd.0001334 · Cited by 40 · see citing works
Sahiner, M., Sagbas, S., & Bitlisli, B. O. (2015) · Journal of Applied Polymer Science · doi:10.1002/app.41876 · Cited by 37 · see citing works
In vitro microbicidal, anti‐biofilm and cytotoxic effects of different commercial antiseptics
Ortega‐Peña, S., Hidalgo-González, C., Robson, M. C., & Krötzsch, E. (2016) · International Wound Journal · doi:10.1111/iwj.12625 · Cited by 37 · see citing works
Self-citationHiro, M. E., Pierpont, Y. N., Ko, F., Wright, T. E., Robson, M. C., & Payne, W. G. (2012) · Europe PMC (PubMed Central) · Cited by 36 · see citing works
Self-citationVizzini, A., Pergolizzi, M., Vazzana, M., Salerno, G., Sano, C. D., Macaluso, P., Arizza, V., Parrinello, D., Cammarata, M., & Parrinello, N. (2007) · Developmental & Comparative Immunology · doi:10.1016/j.dci.2007.10.006 · Cited by 36 · see citing works
Management of orocutaneous fistulas using a vacuum-assisted closure system
Tian, B. W. C. A., Khoo, D., Tay, A. C., Soo, K. C., Tan, N. C., Tan, H. K., & Iyer, N. G. (2013) · Head & Neck · doi:10.1002/hed.23393 · Cited by 35 · see citing works
- Authors
- Robson, M. C., Stenberg, B. D., & Heggers, J. P.
- Affiliations
- Shriners Hospitals for Children - Galveston (US)
- Venue
- Clinics in Plastic Surgery
- Publisher
- Elsevier BV
- Published
- 1990-07
- Volume
- 17
- Issue
- 3
- Pages
- 485-492
- ISSN
- 0094-1298 (ISSN-L)
- OpenAlex
- W2417880793
- Cited by
- 266
- References
- 54
- Citations by year
- 2026: 2 · 2025: 5 · 2024: 5 · 2023: 10 · 2022: 8 · 2021: 6 · 2020: 9 · 2019: 4 · 2018: 3 · 2017: 4 · 2016: 6 · 2015: 10 · 2014: 6 · 2013: 12 · 2012: 16
- FWCI
- 4.13
- Type
- journal article
- Language
- en
- Open access
- closed
- Locations
- Clinics in Plastic Surgery (publishedVersion)
- PubMed (publishedVersion)
- Topics
- Health Sciences › Medicine › Rehabilitation › Wound Healing and Treatments
- Health Sciences › Medicine › Surgery › Surgical site infection prevention
- Health Sciences › Medicine › Public Health, Environmental and Occupational Health › Streptococcal Infections and Treatments
- Keywords
- wound healing, wound infection, bacterial inoculum, beta-hemolytic streptococci, wound complications, bacterial adhesion
- MeSH terms
- Bacterial Infections, Humans, Wound Healing, Wound Infection
About these checks
Registry, retraction, Cites and statistics results are computed, not judged, with one exception: a printed reference that no index lists is read once by a model before it counts as a citation error. Claims are extracted by a model and kept only when their quote appears verbatim in the text; each cited source is then checked, with a model’s help, for whether it says what the claim relies on. Those verdicts can be wrong — read the claim’s quote and the cited source before relying on one.
Statistics and arithmetic are recomputed, not judged.
Confidence bands are shown only for fields calibrated on our annotated test set. None is calibrated yet, so no band is shown.
What counts as a claim ›How we measure confidence ›How we check this ›
Are you an author, or do you see a problem with this page? Request a review
