The DOI matches its Crossref record.
Identification of a calcium-binding protein as a calcium-dependent regulator of brain adenylate cyclase.
Open accessAbstract
An activating factor of adenylate cyclase (EC 4.6.1.1) HAS BEEN OBTAINED FROM DETERGENT-DISPERSED PREPARATIONS OF PORCINE CEREBRAL CORTEX BY COLUMN CHROMATOGRAPHY ON ECTEOLA-cellulose. The factor was identified by acrylamide gel electrophoresis and by enzyme activation studies as the Ca2+-binding protein that regulates the activity of a brain cyclic nucleotide phosphodiesterase. This Ca2+-binding protein confers a Ca2+-dependent activation upon the adenylate cyclase, which is reversed by the subsequent addition of egta in excess of the free Ca2+. It is proposed that this Ca2+-dependent regulator controls enzymatic activities responsible for the synthesis of adenosine 3':5'-monophosphate and for the hydrolysis of guanosine 3':5'-monophosphate.
Overview
The claims and statistics of this paper haven’t been checked yet.
Run the check — free, no account needed. It reads the open-access text and checks the sources it cites.
Integrity signals
Registry
Cites
Statistics
Verification
Claims the paper makes
The claims and statistics of this paper haven’t been checked yet.
Run the check — free, no account needed. It reads the open-access text and checks the sources it cites.
Self-check
Percentages, sums and reported differences re-computed from the paper’s own numbers.
The self-check needs the paper’s full text.
Citations
Cited by
Forskolin: unique diterpene activator of adenylate cyclase in membranes and in intact cells.
Seamon, K. B., Padgett, W., & Daly, J. W. (1981) · Proceedings of the National Academy of Sciences · doi:10.1073/pnas.78.6.3363 · Cited by 1,658
A mechanism for the Hebb and the anti-Hebb processes underlying learning and memory.
Lisman, J. (1989) · Proceedings of the National Academy of Sciences · doi:10.1073/pnas.86.23.9574 · Cited by 1,127
Livingstone, M. S., Sziber, P. P., & Quinn, W. G. (1984) · Cell · doi:10.1016/0092-8674(84)90316-7 · Cited by 587
Watterson, D. M., Sharief, F., & Vanaman, T. C. (1980) · Journal of Biological Chemistry · doi:10.1016/s0021-9258(19)86127-6 · Cited by 586
The Drosophila learning and memory gene rutabaga encodes a - adenylyl cyclase
Levin, L. R., Han, P.-L., Hwang, P. M., Feinstein, P. G., Davis, R. L., & Reed, R. R. (1992) · Cell · doi:10.1016/0092-8674(92)90185-f · Cited by 517
Metadata
- Authors
- Brostrom, C. O., Huang, Y. C., Breckenridge, B. M., & Wolff, D. J.
- Venue
- Proceedings of the National Academy of Sciences
- Published
- 1975-01
- Volume
- 72
- Issue
- 1
- Pages
- 64-68
- ISSN
- 0027-8424 (ISSN-L)
- 1091-6490
- OpenAlex
- W2028519419
- Cited by
- 545
- References
- 0
- FWCI
- 18.04
- Type
- journal article
- Language
- en
- Open access
- green
About these checks
Registry, retraction, Cites and statistics results are computed, not judged, with one exception: a printed reference that no index lists is read once by a model before it counts as a citation error. Claims are extracted by a model and kept only when their quote appears verbatim in the text; each cited source is then checked, with a model’s help, for whether it says what the claim relies on. Those verdicts can be wrong — read the claim’s quote and the cited source before relying on one.
Statistics and arithmetic are recomputed, not judged.
Confidence bands are shown only for fields calibrated on our annotated test set. None is calibrated yet, so no band is shown.
What counts as a claim ›How we measure confidence ›How we check this ›
Are you an author, or do you see a problem with this page? Request a review
How to cite
Cite CoChat for the checks on this page, and the paper for its own findings.
- This page
- CoChat. (2026). Citation check: Identification of a calcium-binding protein as a calcium-dependent regulator of brain adenylate cyclase. https://app.cochat.ai/papers/10.1073/pnas.72.1.64
- The paper
- Brostrom, C. O., Huang, Y. C., Breckenridge, B. M., & Wolff, D. J. (1975). Identification of a calcium-binding protein as a calcium-dependent regulator of brain adenylate cyclase. Proceedings of the National Academy of Sciences. https://doi.org/10.1073/pnas.72.1.64
Data sources
Bibliographic data: Semantic Scholar, OpenAlex, Crossref.
Contains information from the Semantic Scholar Academic Graph Datasets, made available under the ODC Attribution License (ODC-BY 1.0).
Semantic Scholar’s data is described in: Kinney, R., et al. (2023). The Semantic Scholar Open Data Platform. arXiv:2301.10140.
